TIAN Zhigang

Release time :2015-03-20

Professor, Academician of Chinese Academy of Engineering

Contact Information
School of Life Sciences; University of Science & Technology of China
Tel: 86-551-63600845
Fax: 86-551 -63600832


Personal Profile
03/1978-12/1982: M.D., Shanxi Medical University, China
03/1983-08/1985: M.S.,Immunology, Shandong Acad Med Sci, China
03/1986-03/1989:Ph.D., Immunology, Normal Bethune Med Univ, China.
04/1989-12/2001: Assist/Associat/Full Professor, Shandong Acad Med Sci, China
08/1994-06/1996:Visiting Scientist, NCI, NIH, USA
02/1999-08/1999: Visiting Professor, Med College Virginia, Richmond
08/2000-12/2000: Visiting Scientist, NCI, NIH, USA
01/2001-present: Professor, Univ Sci Tech China, China
01/2002-04/2002: Visiting Scientist, NIAAA, NIH, USA
05/2002-04/2003: Visiting Professor, Kanazawa Univ Cancer Inst, Japan

Research Interests
1) Innate immunity of liver
2) Regulatory function of NK cells in immune response;
3) Differentiation of NK cells.

Selected Publications
1.Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome. Cell. 2015 Jan 15;160(1-2):62-73.
2.Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*,
Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jan 9. pii: S0168-8278(14)00956-8.
3.Li S, Sun R, Chen Y, Wei H,
Tian Z*. TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression. Cancer Res. 2015 Jan 19.[Epub ahead of print]
4.Wang J, Li F, Wei H, Lian ZX, Sun R,
Tian Z*. Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation. J Exp Med. 2014 Nov 17;211(12):2397-410.
Tian Z. Outflanking HCV. Nat Immunol. 2014 Jan; 15(1):6-8.
6. Xu L, Yin W, Sun R, Wei H,
Tian Z*. Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice. Hepatology. 2014 Feb; 59(2):443-52.
7. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G,
Tian Z*, Tschopp J, Zhou R*. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63.
8. Peng H, Jiang X, Chen Y, Sojka D, Gao X, Sun R, Wei H, Yokoyama W,
Tian Z*. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest 2013, 123(4):1444-1456.
9. Li F, Wei H, Wei H*, Gao Y, Xu L, Yin W, Sun R,
Tian Z*. Blocking the Natural Killer (NK) Cell Inhibitory Receptor NKG2A Increases Activity of Human NK Cells and Clears HBV Infection in Mice. Gastroenterology. 2013, 144:392-401.
10. Xu L, Yin WW, Wei HM, Sun R,
Tian Z*. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice. PNAS USA 2013; 110:16993-8.
11. Wang J, Li F, Sun R, Gao X, Wei H, Li L,
Tian Z*. Airway bacteria dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun 2013; 4:2106.
12. Lan PX, Zhang C*, Han QJ, Zhang J,
Tian ZG*. Reversal of HBV-induced systemic adaptive immunotolerance by recovering hepatocyte-intrinsic immunity. Hepatology 2013, 58:73-85.
13.Wang X, Sun R*, Wei H,
Tian Z*. HMGB1-TLR4-IL-23-IL-17A axis in drug-induced lethal hepatitis: Interaction of γδ T cells with macrophages. Hepatology. 2013; 57:373-84.
14. Huang M, Sun R*, Wei H,
Tian Z*. Simultaneous knockdown of multiple ligands of NKG2D high efficiently prevents NK cell-mediated fulminant hepatitis. Hepatology. 2013; 57:277-88.