Chengdong Huang, Ph.D.
Professor, School of Life Sciences
University of Science & Technology of China
443 Huangshan Street, Hefei City, Anhui 230027, P.R.China
Education and Appointment:
2017–present:Professor, University of Science and Technology of China (USTC)
2017：Associate Scientist, St Jude Children’s Research Hospital, Department of Structural Biology
2015-2017:Postdoctoral Fellow, University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics
2012-2015:Postdoctoral Fellow, Rutgers University, Department of Chemistry and Chemical Biology,
2010-2012:Postdoctoral Fellow, Stony Brook University, Department of Biochemistry and Cell Biology
2004-2010:Ph.D., Auburn University, Department of Chemistry and Biochemistry
2001-2004:M.S., Dalian Institute of Chemical Physics, Chinese Academy of Sciences
1997-2001:Dalian University of Technology
Areas of expertise:
Biomolecular NMR spectroscopy, Structural biology, Molecular Machineries, Molecular Chaperone.
Research Interest:
Our current work primarily focuses on determination of the structural and dynamic basis for the function and assembly of large protein machineries.
Honors & Awards:
2008-2010 Alabama EPSCoR GRSP Scholarship（Round 3, 4 and 5）
2009-2010 Auburn University Outstanding Doctoral Graduate Award
2009-2010 Graduate Council’s Outstanding Graduate Award, Department of Chemistry and Biochemistry, Auburn University
2010 Award for Academic Excellence as Outstanding Graduate Student, Auburn University
2010 Auburn University President's Award
Selected Publications:
1.Huang, Chengdong; Kalodimos, Charalampos, G. Structures of Large Protein Complexes by NMR. Annu. Rev.Biophys. (2017) 46, 317-336.
2.Huang, Chengdong; Rossi, Paolo; Saio, Tomohide; Kalodimos, Charalampos, G. Structural basis for the antifolding activity of a molecular chaperone. Nature. (2016) 537, 202-206.
3.Rath, Poonam;Huang, Chengdong; Wang, Tao; Wang, Tianzhi; Li, Huilin; Prados-Rosales, Rafael; Elemento, Olivier; Casadevall, Arturo; Nathan, Carl F. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc.Natl. Acad. Sci. USA. (2013) 110(49), E4790-4797.
4.Huang, Chengdong*; Li, Guangtao*; Lennarz, William J. Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. (*Equal contribution) Proc.Natl. Acad. Sci. USA(2012) 109(25), 9792-9297.
5.Li, Guangtao*; Huang, Chengdong*, Zhao, Gang; Lennarz, William J. Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97. (*Equal contribution) Proc.Natl. Acad. Sci. USA(2012), 109(10), 3737-3741.
6.Huang, Chengdong; Bhaskaran, Rajagopalan; Mohanty, Smita. Eukaryotic N-glycosylation Occurs Via membrane-anchored C-terminal domain of Stt3p subunit of oligosaccharyl transferase.J. Biol. Chem. (2012) 287(39), 32450-32458.
7.Huang, Chengdong; Mohanty, Smita. Challenging the Limit: NMR Assignment of a 31 kDa Monomeric Helical Membrane Protein. J. Am. Chem. Soc. (2010), 132, 3662–3663.
8.Huang, Chengdong; Mohanty, Smita, Bannerjee, Monimoy. A novel method of production and biophysical characterization of C-terminal domain of Stt3p, the catalyzing subunit of yeast Oligosaccharyl Transferase.Biochemistry (2010), 49, 1115–1126.
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