Zhenye Yang

ADDRESS:

School of Life Sciences

University of Science & Technology of China,

443 Huangshan Street, Hefei City, Anhui 230027

TEL:0551-63600613

EDUCATION AND RESEARCH EXPERIENCE

2013-Professor, School of Life Sciences, University of Science & Technology of China

2011-2012CRTA Fellow, National Cancer Institute, NIH

2005-2010Research Affiliate/Scientist, Wadsworth Center, New York State Department of Health

1999-2005Ph.D, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

1995-1999 B.S., School of Life Science, Shanghai Jiao Tong University

RESEARCH INTERESTS

Function of cell division regulators in tumor progression

Mechanism of anti-mitotic therapeutics and combination therapy

Roles of inflammation in anti-mitotic and target chemotherapy

REPRESENTATIVE PUBLICATIONS

Wan Y, Yang Z, Guo J,  Zhang Q, Zeng L, Song W, Xiao Y and Zhu X. 2012. Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res.doi: 10.1038/cr.2012.47

Yang Z., Kenny A., Brito D. and Rieder C. 2009. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol.186: 675-684.

Yang Z., Loncarek J., Khodjakov A. and Rieder C. 2008. Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat .Cell Biol. 10: 748-751.

Brito D.*, Yang Z.* and Rieder C. 2008. Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied. J Cell Biol. 182(4):623-9. (* Co-first author)

Yang Z., Tulu S., Wadsworth P. and Rieder C. 2007. Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint. Curr. Biol.17(11): 973-80.

Yang Z., Guo J., Chen Q., Du J., Ding C., and Zhu X.2005. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25: 4062-4074.

Yang, Z., Guo J., Li N., Qian M., Wang S, and. Zhu X. 2003. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13:275-83.