Qiang Liu, Ph.D., Professor in Neuroscience

Dr. Qiang Liu is the recipient of National Science Foundation for “Distinguished Young Scholars” in 2021 and “Excellent Young Scientist” in 2014.

Dr. Qiang Liu received Ph.D. degrees from Institute of Biophysics, Chinese Academy of Sciences. He completed his postdoctoral training at Washington University School of Medicine and continued his research at Howard Hughes Medical Institute (HHMI)/University of Pennsylvania School of Medicine as a Research Associate. Dr. Qiang Liu joined the faculty of School of Life Sciences, University of Science & Technology of China in 2012.

Research Interests:

One of the central questions in neuroscience is how the brain acquires, processes and stores information. Memory is the process of storing and then remembering this information. Our laboratory is interested in elucidating the physiological mechanisms underlying learning and memory, and also pathogenic mechanisms of neurodegenerative disorders, such as Alzheimer’s Disease, that phenotypically show deficits in learning and memory. Specifically, we’re exploring: 1) how brain lipid metabolism influence learning and memory under both physiological and pathological conditions (Alzheimer’s Disease); 2) how epigenetic mechanism is involved in learning and memory process; 3) how brain energy homeostasis contributes to learning and memory.

Selected Publications：

1. Li XH, Zhang J, Li DF, He C, He K, Xue T, Wan L, Zhang C and Liu Q. Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone acetylation-mediated memory. Neuron 109:1-14, 2021.

2. Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q. Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing. Mol Neurodegener. 16(1):66, 2021

3. Li D, Zhang J, Wang M, Li X, Gong H, Tang H, Chen L, Wan L and Liu Q. Activity dependent LoNA Regulates Translation by Coordinating rRNA Transcription and Methylation. Nat Commun. 9（1）：1726，2018.

4.  Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q. SFRS11 loss leads to aging-associated cognitive decline by modulating LRP8 and ApoE. Cell Reports. 28(1):78-90, 2019.

5.  Zhang J, Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein Cell. 6(4):254-64，2015.

6.  Li D, Zhang J, Li X, Chen Y, Yu F, Liu Q. Insights into lncRNAs in Alzheimer's disease mechanisms. RNA Biol. 18:7, 1037-1047, 2021.

7.  Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, Zhang Z, Cho S, Sherrill-Mix S, Wan L, Dreyfuss G. U1 snRNP Determines mRNA Length and Regulates Isoform Expression. Cell. 150: 53-64, 2012.

8. Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G.Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biology. 9(1): e1000575, 2011.

9. Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1. Neuron 56:66-78, 2007.

10. Liu Q, Zhang J, TrotterJ, ChengC, HanX, WeeberEJ, BaoJ, HerzJ, Bu G.Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J.Neurosci. 30:17068-17078. 2010.

11. Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener. 4:17, 2009.

12. Liu Q, Zhang J, Zhu H, Qin C, Chen Q, Zhao B. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB J.21:61-73, 2007.

Contacts:

E-mail：liuq2012@ustc.edu.cn

Office：0551-63601179