University of Science & Technology of China
Hefei, Anhui 230027, P.R. China
Tel: 0551-63607631
E-mail: wuqf@ustc.edu.cn
Homepage:http://staff.ustc.edu.cn/~wuqf/
Education & Working Experience:
Postdoctoral Fellow /Assistant Specialist, University of California-Riverside, CA, 2006-2010
Research Associate, Northwestern University, IL, 2004-2006
Visiting Scholar, Copenhagen University, Denmark, 2001-2002
Ph.D., Institute of Genetics & Developmental Biology, Chinese Academy of Sciences, 1999-2003
Research Interests:
Systems biology of virus-host interaction: RNA silencing provides protection against virus infection in Drosophila as has been established in plants, but the antiviral mechanism in Drosophila is still very limited. My laboratory concentrates on some fundamental questions in the field: how fruit flies perceive and respond to viruses, and how viruses counter-respond to host defense responses. We are using genomics, computational and molecular approaches to study the dynamic changes of endogenous small RNAs and message RNAs that occur in response to virus challenge.
Exploiting the functional diversity of non-coding RNAs (ncRNAs): We are using combined genomic, bioinformatic and high throughput platform technologies to catalogue ncRNAs associated with different chromatin remodeling complexes, dissect the mechanistic roles of ncRNAs in mammalian development. In parallel, both in-house and public gene expression data sets are using to profile gene expression of ES cells and differentiated cells, in order to find lead compounds for the maintenance of ES cell pluripotency and directed differentiation.
Selected Publications:
1.Guo D, Xu W, Cui T, Rong Q, Wu Q*. Protein-coding circular RNA enhances antiviral immunity via JAK/STAT pathway in Drosophila. mBio. 2024. 19:e0146924
2.Chen D, Shi C, Xu W, Rong Q, Wu Q*. Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila. mBio. 2024. 15:e01378-23.
3.Rong Q, Xi Z, Guo D, Xu W, Zhang L, Wu Q*. Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila. J Virol. 2024. 98(5):e0017724.
4.Cui T, Bai Q*, Yu W, Guo D, Ban Y, Chen K, Raza Ali, Zhou G, Wu Q*. Chromosome-levelgenome assembly and population genomic analysis provide novel insights into the immunity and evolution of Sogatella furcifera. Genomics. 2023. 115: 110729.
5.Yan W, Zhu Y, Liu W, Zou C, Jia B, Chen ZQ, Han Y, Wu J, Yang DL, Zhang Z, Xie L,Chen B, Li R, Ding SW*, Wu Q*, Guo Z*. Discovery of aphid-transmitted Rice tiller inhibition virus from native plants through metagenomic sequencing. PLoS Pathogen. 2023.19(3):e1011238.
6.Zhang L, Xu W, Gao X, Li W, Qi S, Guo D, Ajayi E, Ding, SW, Wu, Q*. lncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila. Cell Host Microbe, 2020. 27(1), 115-128.
7. Gao X, Fu Y, Ajayi E, Guo D, Zhang L, Wu Q*. Identification of genes underlying phenotypic plasticity of wing size via insulin signaling pathway by network-based analysis in Sogatella furcifera. BMC genomics. 2019. 20(1), 396.