Dr. Qinghua Shi is a principal investigator and professor in Genetics and Cell Biology at Hefei National Laboratory for Physical Science at Microscale and School of Life Science, University of Science and Technology of China. He is a recipient of the “Hundred Talents Program” of the Chinese Academy of Sciences, the National Science Fund for Distinguished Young Scholars, the Wang Kuancheng Award (First Prize), the Tan Jiazhen Life Science Award (Innovation Award), and the Chen Linyi Foundation Medical Contribution Award. He has led the National Key Research and Development Programs, the Major Program of the National Natural Science Foundation of China, etc.
Prof. Shi’s lab strives to understand the genetic causes of human infertility and the underlying molecular mechanisms. The lab established a vast Human Reproductive Disease Resource Bank and a platform for screening and functional identification of pathogenic mutations responsible for infertility. Based on this platform, they have reported dozens of pathogenic mutations related to human infertility disorders, as well as new meiotic regulatory factors and mechanisms. As the first or corresponding author, Prof. Shi has published more than 150 peer-reviewed SCI papers in prestigious international journals such as Nature, Am J Hum Genet, J Exp Med, Cell Res, Cell Discov, Sci Adv, Nat Comm, and Nucleic Acids Res. He has also been invited to write over 15 review articles, and his papers has been cited over 6,000 times.
Prof. Shi also served as a member of expert group for the Ministry of Science and Technology's Major Scientific Research Program and the National Key Research and Development Program. He was twice elected as the chairman of the Reproductive Science Division of the Chinese Physiological Society. Currently, he holds several key academic positions, including the President of the Reproductive Cell Biology Division of the Chinese Society for Cell Biology, Chairman of the Anhui Society for Cell Biology, Vice Chairman of the Reproductive Medicine and Genetics Committee of the Chinese Human Health Science and Technology Promotion Society, and Senior Director of the Chinese Society for Cell Biology. He serves as an executive editor or editorial board member for journals, including Biology of Reproduction, Asian Journal of Andrology, PloS One, Heredity, Chinese Journal of Cell Biology, and Life Science Journal.
Education and Research Experience
1985.09 - 1988.10 | Graduate for M.S. degree. Kunming Institute of Zoology, Chinese Academy of Sciences. |
1988.11 - 1992.09 | Research Assistant. Anhui Institute of Occupational Health. |
1992.10 - 1993.10 | Guest Scientist. GSF-National Research Center for Environment and Health, Germany. |
1994.09 - 1998.06 | Graduate for Ph.D. degree. GSF-National Research Center for Environment and Health, Germany and, Nanjing Normal University. |
1998.11 - 2001.12 | Postdoctoral fellow. Department of Medical Genetics, University of Calgary, Canada. |
2002.01 - 2004.12 | Research Fellow. Institute of Chemistry and Cell Biology, Department of Cell Biology, Harvard Medical School. |
2004.12 - 2018.12 | Principal Investigator and Professor. School of Life Science, University of Science and Technology of China. |
2018.12 - present | Principal Investigator and Professor. The First Affiliated Hospital, School of Basic Medicine, University of Science and Technology of China. |
Research Interests
1. Cellular and molecular regulation of mammalian meiosis.
2. Origins and mechanisms of mitotic and meiotic aneuploidy.
3. Molecular bases and mechanisms of human infertility.
Current Research Projects
1. Molecular Mechanisms of Meiotic Recombination Regulation (NSFC, Major Project)
2. Genetic Basis and Mechanisms of Meiotic Abnormalities in Patients with Spermatocyte Developmental Arrest (NSFC, China-Israel International (Regional) Cooperation and Exchange Project)
3. Construction and Regulatory Mechanisms of the Spermatogenic Microenvironment (MOST, National Key R&D Program)
4. Pathogenic Factors of Spermatogenesis Disorders (MOST, National Key R&D Program)
5. Molecular Basis and Mechanisms of Human Spermatogenic Disorders (NSFC, Joint Funding Project)
6. Genetic Diagnosis of Male Infertility (The Joint Fund for New Medicine of USTC)
7. Molecular Diagnostic Kit for Male Infertility (Hefei Comprehensive National Science Center, Global Select Project of the Institute of Health and Medicine)
Reresentative Publications
1. Fan S, Y Wang, H Jiang, X Jiang, J Zhou, Y Jiao, J Ye, Z Xu, Y Wang, X Xie, H Zhang, Y Li, W Liu, X Zhang, H Ma, B Shi, Y Zhang, M Zubair, W Shah, Z Xu*, B Xu* and Shi Q (史庆华)*, A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation. Cell Discov 9(1): 88, 2023.
2. Ma H, Li T, Xie X, Jiang L, Ye J, Gong C, Jiang H, Fan S, Zhang H, Shi B, Zhang B, Jiang X, Li Y, Zhou J, Xu J, Zhang X, Hou X, Yin H, Zhang Y*, and Shi Q (史庆华)*. RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes. Sci Adv 8(2):eabk1789, 2022.
3. Fan S, Y Jiao, R Khan, X Jiang, A R Javed, A Ali, H Zhang, J Zhou, M Naeem, G Murtaza, Y Li, G Yang, Q Zaman, M Zubair, H Guan, X Zhang, H Ma, H Jiang, H Ali, S Dil, W Shah, N Ahmad, Y Zhang and Shi Q (史庆华)*, Homozygous mutations in C14orf39/SIX6OS1 cause non-obstructive azoospermia and premature ovarian insufficiency in humans. Am J Hum Genet 108, 324-336, 2021.
4. Zhang B, Ma H, Khan T, Ma A, Li T, Zhang H, Gao JN, Zhou JT, Li Y……Zhang Y*, Shi Q (史庆华)*, A DNAH17 Missense Variant Causes Flagella Destabilization and Asthenozoospermia. J Exp Med, 217(2): 2020.
5. Yin H, Ma H, Hussain S, Zhang H, Xie X, Jiang L, Jiang X, Iqbal F, Bukhari I, Jiang H, Ali A, Zhong L, Li T, Fan S, Zhang B, Gao J, Li Y, Nazish J, Khan T, Khan M, Zubair M, Hao Q, Fang H, Huang J, Huleihel M, Sha J, Pandita TK, Zhang Y *, Shi Q (史庆华)*, A homozygous FANCM frameshift pathogenic variant causes male infertility. Genet Med, 21(1):62-70, 2019.
6. Jiang L, Li T, Zhang X, Zhang B, Yu C, Li Y, Fan S, Jiang X, Khan T, Hao Q, Xu P, Nadano D, Huleihel M, Lunenfeld E, Wang PJ, Zhang Y *, Shi Q (史庆华)*, RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Curr Biol, 27(10):1498-1505 e1496, 2017.
7. Zhang Y, Zang Q, Zhang H, Ban R, Yang Y, Iqbal F, Li A*, Shi Q (史庆华)*, DeAnnIso: a tool for online detection and annotation of isomiRs from small RNA sequencing data. Nucleic Acids Res, 44(W1):W166-175, 2016.
8. Zhang Y, Yu Z, Ban R, Zhang H, Iqbal F, Zhao A, Li A *, Shi Q (史庆华)*, DeAnnCNV: a tool for online detection and annotation of copy number variations from whole-exome sequencing data. Nucleic Acids Res, 43(W1):W289-294, 2015.
9. Zhang Y, Zhong L, Xu B, Yang Y, Ban R, Zhu J, Cooke HJ, Hao Q, Shi Q (史庆华)*, SpermatogenesisOnline 1.0: a resource for spermatogenesis based on manual literature curation and genome-wide data mining. Nucleic Acids Res, 41(Database issue):D1055-1062, 2013.
10. Shi Q (史庆华), King RW*. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature, 437(7061):1038-1042, 2005.
Contact Information
Address：University of Science and Technology of China, 230026 Hefei,
CAS Center for Excellence in Molecular Cell Science, P. R. China
Tel: 86-551-63600344(Off)/63600442(Lab)
Labweb: http://mcg.ustc.edu.cn
E-mail: qshi@ustc.edu.cn