Contact Information
School of Life Sciences; University of Science & Technology of China
Tel: 86-551-63600845
Fax: 86-551 -63600845
E-mail: tzg@ustc.edu.cn
Homepage:ioi.ustc.edu.cn
Personal Profile
03/1978-12/1982: M.D., Shanxi Medical University, China
03/1983-08/1985: M.S.,Immunology, Shandong Acad Med Sci, China
03/1986-03/1989:Ph.D., Immunology, Normal Bethune Med Univ, China.
04/1989-12/2001: Assist/Associat/Full Professor, Shandong Acad Med Sci, China
08/1994-06/1996:Visiting Scientist, NCI, NIH, USA
02/1999-08/1999: Visiting Professor, Med College Virginia, Richmond
08/2000-12/2000: Visiting Scientist, NCI, NIH, USA
01/2001-present: Professor, Univ Sci Tech China, China
01/2002-04/2002: Visiting Scientist, NIAAA, NIH, USA
05/2002-04/2003: Visiting Professor, Kanazawa Univ Cancer Inst, Japan
Research Interests
1) NK Cell Biology;
2) Liver immunology;
3) Tumor immunology;
4) Immunotherapy
Selected Publications
1. Zheng X* , Hou Z, Qian Y, Zhang Y, Cui Q, Wang X, Shen Y, Liu Z, Zhou Y, Fu B, Sun R, Tian Z* , Huang G*, Wei H*. Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nat Immunol 2023, 24(5):802-813.
2. Bai L, Vienne M, Tang L, Kerdiles Y, Etiennot M, Escalière B, Galluso J, Wei H, Sun R, Vivier E, Peng H*, Tian Z*. Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop.Science 2021, 26;371(6536):eaba4177.
3. Zhou Y, Fu B*,Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. PBX1 expression in uterine natural killer cells drives fetal growth. Sci.Transl. Med. 2020; 12:1798.
4. Zhou J, Peng H*, Li K, Qu K, Wang B, Wu Y, Ye L, Dong Z, Wei H, Sun R, Tian Z*. Liver-resident NK cells control antiviral activity of hepatic T cells via PD-1/PD-L1 axis. Immunity 2019; 50:403-417.
5. Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z*, Wei H*. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol 2019; 20:1656-1667.
6. Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, Sun R*, Tian Z*. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol 2018; 723–732.
7. Cong J, Wang X, Zheng X, Wang D, Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab 2018, 28:243-255.
8. Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural Killer Cells Promote Fetal Developmentthrough the Secretion of Growth-Promoting Factors. Immunity 2017, 47:1100-1113.
9. Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z*, Dong Z*. The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education. Immunity 2016, 45:292-304.
10. Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell 2015, 160:62-73.
11. Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol 2014, 15:1126-33.
12. Yan Y, Jang W, Spinetti T, Tardivel A, Castillo R, Guarda G, Tian Z*, Tschopp J, Zhou RB*. ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 2013, 38:1154-63.
13. Li F, Wei H, Wei H*, Gao Y, Xu L, Yin W, Sun R, Tian Z*. Blocking the Natural Killer (NK) Cell Inhibitory Receptor NKG2A Increases Activity of Human NK Cells and Clears HBV Infection in Mice. Gastroenterology 2013, 144:392-401.
14. Xu L, Yin WW, Wei HM, Sun R, Tian Z*. Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice. PNAS USA 2013; 110:16993-8.