Contact Information
Tel: 86-551-63607379 Fax: 86-551-63606783 E-mail: ustcwhm@ustc.edu.cn Homepage: http://ioi.ustc.edu.cn/ |
Personal Profile
12/2015–present: Professor & Vice-Dean of School of Life Sciences,,UnivSci Tech China
12/2005–12/2015: Professor, UnivSci Tech China
09/2001-11/2005: Associate Professor, UnivSci Tech China
07/1996-08/2001: Assist/Asso Professor, Shandong Acad Med Sci
08/2000-06/2003: M.D., Immunology, Shandong Univ.
08/1993-06/1996: M.S., Immunology, Shandong Acad Med Sci
Research Interests
The research in our laboratory focuses on three main topics. 1) The development and transcription regulation of human NK cells. 2) The relationship between human NK subsets and major diseases. We are interested in understanding the mechanisms of hepatitis, Immune escape by Hepatitis B Viruses and the development of auto-immune diseases. 3) Biological Treatment Technology of tumors based on innate immunity. We are currently evaluating the anti-tumor immunochemotherapy of IL-12 based on “pre-existing immunity”. We are also focusing to research and produce the anti-tumor medicine of IL-12.
Selected Publications
Nian Z, Dou Y, Shen Y, Liu J, Du X, Jiang Y, Zhou Y, Fu B, Sun R, Zheng X, Tian Z, Wei H*. IL-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation. Immunity. 2024 Sep 14:S1074-7613(24)00415-1
Zheng X, Hou Z, Qian Y, Zhang Y, Cui Q, Wang X, Shen Y, Liu Z, Zhou Y, Fu B, Sun R, Tian Z, Huang G and Wei H*. Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nature Immunology. 2023 May;24(5):802-813
Wang D, Sun Z, Zhu X, Zheng X, Zhou Y, Lu Y, Yan P, Wang H, Liu H, Jin J, Zhu H, Sun R, Wang Y, Fu B, Tian Z, Wei H*. GARP-mediated active TGF-β1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT. Blood. 2022 Aug 18; blood.2022015474
Wei H* and Fu B*. Make killers sweeter: targeting metabolic checkpoints of NK cells. Nature Immunology. 2020 Sep;21(9):970-971
Zhou Y, Fu B*, Xu X, Zhang J, Tong X, Wang Y, Dong Z, Zhang X, Shen N, Zhai Y, Kong X, Sun R, Tian Z*, Wei H*. PBX1 expression in uterine natural killer cells drives fetal growth. Science Translational Medicine. 2020 Apr 1; 12(537):eaax1798
Xu X*, Han M, Li T, Sun W, Wang D, Fu B, Zhou Y, Zheng X, Yang Y, Li X, Zhang X, Pan A, Wei H*. Effective treatment of severe COVID-19 patients with tocilizumab. PNAS. 2020 May 19; 117(20):10970-10975.
Zhou Y, Fu B, Zheng X, Wang D, Zhao C, Qi Y, Sun R, Tian Z, Xu X*, Wei H*. Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients. National Science Review, 2020 Mar 13; 7(6) : 998-1002
Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z*, Wei H*. Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nature Immunology. 2019 Dec; 20(12):1656-1667
Cong J, Wang X, Zheng X, Wang D , Fu B, Sun R, Tian Z*, Wei H*. Dysfunction of Natural Killer Cells by FBP1-induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metabolism. 2018 Aug 7;28(2):243-255.e5
Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z*, Wei H*. Natural killer cells promote fetal development through the secretion of growth-promoting factors. Immunity. 2017 Dec 19;47(6):1100-1113