Contact Information
Tel: 086-551-63600302
Fax: 086-551-63600831
Email: zrb1980@ustc.edu.cn
Address: Huangshan Road 443, Hefei, Anhui, China R.P. 230027
Homepage: team.ustc.edu.cn/ZHOUJIANGLAB
Personal Profile
09/1998-06/2002, B.S. University of Science & Technology of China
09/2002-06/2007, Ph.D University of Science & Technology of China
07/2007-02/2011, Postdoc University of Lausanne, Switzerland
03/2011-present, Professor University of Science & Technology of China
Research Interests
1. Mechanism of DAMP sensing in sterile inflammation
2. Role and mechanism of DAMP sensing in human diseases
3. Developing drugs targeting DAMP-sensing receptors and sterile inflammation
Selected publications（*co-corresponding author）
1. Yan J, Zhang C, Xu Y, Huang Z, Ye Q, Qian X, Zhu L, Huang G, Wang X, Jiang W, Zhou R. GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity. Nat Immunol. 2024 Oct 2. doi: 10.1038/s41590-024-01973-z.
2. Huang Y, Jiang W, Zhou R. DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways. Nat Rev Immunol. 2024 Apr 29. doi: 10.1038/s41577-024-01027-3
3. Ma M, Jiang W, Zhou R. DAMPs and DAMP-sensing receptors in inflammation and diseases.Immunity. 2024 Apr 9;57(4):752-771.
4. Huang Y, Zhou R. Cytosolic transfer of circulating LPS by EVs. Nat Cell Biol. 2023 Nov 16. doi: 10.1038/s41556-023-01283-w.
5. Xu Y, Yan J, Tao Y, Qian X, Zhang C, Yin L, Gu P, Liu Y, Pan Y, Tang R, Jiang W, Zhou R. Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression. Science. 2022 Sep 2;377(6610):1085-1091. doi: 10.1126/science.abj267
6. Wang X, Cai J, Lin B, Ma M, Tao Y, Zhou Y, Bai L, Jiang W, Zhou R. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity.2021 Jun 8;54(6):1123-1136.e8
7. Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S, Pan Y, Jiang W, Zhou R. Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity. Nat Cell Biol. 2020 Jun;22(6):716-727.
8. Gong T, Liu L, Jiang W, Zhou R. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat Rev Immunol. 2020 Feb;20(2):95-112.
9. Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R. Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Nat Immunol. 2019 Dec;20(12):1681-1691
10. Gong T, Zhou R. ApoC3: an 'alarmin' triggering sterile inflammation. Nat Immunol. 2020 Jan;21(1):9-11.
11. Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan 15;160(1-2):62-73.
12. Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014 ;15(12):1126-33.
13. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R. ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63.