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ZHANG Huafeng


Dr. Huafeng Zhang obtained her Ph. D degree from University of Tokyo in Japan in 2004. She went on for her postdoctoral study in National Cancer Institute of NIH and Johns Hopkins University from 2004 to 2010. Since 2010, Dr. Zhang has been a professor of School of Life Sciences, University of Science and Technology of China. Dr. Zhang’s major research interest is to decipher the interplay and its molecular basis between tumor microenvironment and metabolic reprogramming, elucidating their functions in tumor development and identifying potential targets for anti-cancer therapy, with the focus on elucidating the metabolic crosstalk between cancer cells and immune cells in the tumor microenvironment.

Research Interest:

1. Tumor immunology and metabolism

2. Mechanism of cancer metastasis

3. Anti-cancer drug development

Recent publications (*corresponding author)

  1. Hao Y#, Zhou Z#, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L*, Gao P*, Zhang H*. Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance. Nature Chemical Biology 2025 Jun;21(6):926-938.

  2. Ma W#, Sun Y#, Yan R, Zhang P, Shen S, Lu H, Zhou Z, Jiang Z, Ye L, Mao Q, Xiong N, Jia W, Sun L, Gao P*, Zhang H*. OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB. Molecular Cell2024 Feb 1;84(3):538-551.

  3. Wei H, Suo C, Gu X, Shen S, Lin K, Zhu C, Yan K, Bian Z, Chen L, Zhang T, Yan R, Yang Z, Yu Y, Li Z, Liu R, He J, He Q, Zhong X, Jia W, Wong CM, Dong Z, Cao J, Sun L, Zhang H*, Gao P*. AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity. Cell Metabolism 2025 May 6;37(5):1103-1118.

  4. Yan R#, Zhang P#, Shen S, Zeng Y, Wang T, Chen Z, Ma W, Feng J, Suo C, Zhang T, Wei H, Jiang Z, Chen R, Li ST, Zhong X, Jia W, Sun L, Cang C, Zhang H*, Gao P*. Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion. Nature Immunology 2024 Mar;25(3):483-495.

  5. Wang T#, Zhou Y#, Zhou Z, Zhang P, Yan R, Sun L, Ma W, Zhang T, Shen S, Liu H, Lu H, Ye L, Feng J, Chen Z, Zhong X, Wu G, Cai Y, Jia W, Gao P*, Zhang H*. Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps. Nature Communications 2023 Mar 18;14(1):1513.

Contact:

Lab：63607012；Office：63607131

E-mail: hzhang22@ustc.edu.cn