Main Research Areas
1. Molecular diagnosis and treatment in precision oncology
2. Biological effects of nanomaterials
Holds a Bachelor of Medicine from Wuhan University and a PhD in Science from the National University of Singapore. Conducted postdoctoral research at Johns Hopkins University. Since 2007, he has been a professor in the School of Life Sciences at the University of Science and Technology of China, a principal investigator at the Hefei National Laboratory for Physical Sciences at the Microscale, and a dual-appointed professor at Anhui Provincial Hospital. He has long been engaged in research on tumor molecular pathology and medical translation, publishing over 110 SCI papers (more than 50 as corresponding author) in journals such as Nature Nanotechnology, Nature Communications (2 papers), Cell Research, and Cancer Research (4 papers). His papers have been cited over 6,500 times, with an h-index of 49. He has received the CAS Outstanding Mentor Award, awards from the Endocrine Society and the Susan G. Komen Foundation in the United States, and support from the French Innovative Talent Program. He serves as a senior editorial board member or editor for several international journals, including the American Journal of Cancer Research, and is a review expert for various national and international research/talent funds, as well as for the National Science and Technology Progress Award, the Ministry of Science and Technology Key R&D Programs, and the National Natural Science Foundation's key projects.
Representative Papers
1. Wu M, Zhang X, Chiou YS, Qian W, Liu X, Zhang M, Yan H, Li S, Li T, Han X, Qian P, Liu S, Pan Y,Wu Z, Lobie PE*, Zhu T*. （2022）Cancer Stem Cell Regulated Phenotypic Plasticity Protects Metastasizing Tumor Cells from Ferroptosis. Nat Commun. 13(1):1371
2. Yuan H, Yan L, Wu M, Shang Y, Guo Q, Zhang X, Zhu Y, Wu Z, Lobie PE*, Zhu T*. （2022）Analysis of the oestrogen receptor-associated lncRNA landscape identifies a role for ERLC1 in breast cancer progression. Cancer Res. 82(3):391-405
3. Lu X, Zhu Y, Bai R, Wu Z, Qian W, Yang L, Pandey V, Liu Y, Lobie PE, Chen C*, Zhu T*. (2019) Long-term pulmonary pre-exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades. Nature Nanotechnol. 14(7):719-727
4. Zhang W, Wu M, Kang Y, Chong QY, Zhang M, Qian W, Zhang X, Hu L, Zhong Y, Qian P, Kong X, Li G, Ding K, Lobie PE*, Zhu T*. （2018）Loss of Estrogen Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer Cells. Cancer Res. 78(17):4915-4928
5. Li G, Wu X, Qian W, Wu ZS, Cai H, Sun X, Zhang W, Tan S, Qian P, Ding K, Lu X, Zhang X, Yan H, Song H, Huang S, Wu Q, Lobie PE, Shan G, Zhu T*. (2016) CCAR1 5'UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance. Cell Res 26:655-73.
6. Liu Y, Chen C, Qian P, Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q, Liu S, Zhang H, Zhao F, Wicha MS, Zhu T*, Zhao Y*. (2015) Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell specific inhibitor. Nat Commun. 6,5988
7. Lu X, Liu Y, Kong X, Lobie PE, Chen C*, Zhu T*. (2013) Nanotoxicity: A growing need for study in the endocrine system. Small 9,1654-71
8. Qian PX, Banerjee A, Wu ZS, Zhang X, Wang H, Pandey V, Zhang WJ, Lu XF, Tan S, Lobie PE*, Zhu T*. (2012) Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 promotes mammary epithelial cell oncogenic transformation via targeting multiple stem cell factors. Cancer Res. 72,6036-6050.
9. Jin K, Kong X, Shah T, Penet MF, Wildes F, Sgroi DC, Ma XJ, Huang Y, Kallioniemi A, Landberg G, Bieche I, Lobie PE, Davidson NE, Zaver M. Bhujwalla ZM, Zhu T*, Sukumar S*. (2012) HOXB7 renders breast cancer resistant to tamoxifen through activation of the EGFR Pathway. Proc Natl Acad Sci U S A. 109，2736-41.
10. Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, Zhang W, Tan S, Pandey V, Yao Y, Wang P, Zhao L, Wang J, Wu Q, Song E, Lobie PE, Yin Z*, Zhu T*. (2011) Pivotal Role of Reduced let-7g Expression in Breast Cancer Invasion and Metastasis. Cancer Res. 71,6463-6474.
Contact Information
Tel: +86-551-63601505
Fax: +86-551-63601505
Email: zhut@ustc.edu.cn