Main Research Interests
1. Interaction between oncogenes and tumor suppressor genes, and their roles in tumor formation
2. Molecular mechanisms of non-coding RNA in tumorigenesis and development
3. Tumor microenvironment and its role in tumorigenesis
Professor and PhD advisor. Graduated from the School of Life Sciences at Anhui University in 2000 with a Bachelor of Science degree. From 2002 to 2007, studied at the School of Life Sciences at the University of Science and Technology of China, earning a PhD. Conducted postdoctoral research at the University of Pennsylvania School of Medicine from 2007 to 2011. Since 2011, has been a professor at the School of Life Sciences at the University of Science and Technology of China. Research focuses on signaling pathways mediated by oncogenes and tumor suppressor proteins and their roles in tumor formation, especially the molecular mechanisms of non-coding RNA in tumorigenesis. Aims to deeply analyze the signaling networks of tumor occurrence and development and identify new potential targets for cancer therapy. Major research findings have been published in international journals such as Molecular Cell, PNAS, Nature Communications, and EMBO Journal. Selected for the Ministry of Education's New Century Excellent Talents Support Program in 2013 and received the National Natural Science Foundation's Outstanding Youth Science Fund project in 2014.
Representative Academic Papers (* Corresponding Author)
1. Chenfeng Wang#, Yang Yang#, Xianning Wu#, Jingxin Li, Kaiyue Liu, Debao Fang, Bingyan Li, Ge Shan, Xinyu Mei*, Fang Wang* and Yide Mei* Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis. Proc Natl Acad Sci U S A 119: e2111409119. (2022)
2. Guang Zhang#, Yang Yang#, Hao Hu, Kaiyue Liu, bingyan Li, Yu Zhu, Zhongyu Wang, Qingfa Wu and Yide Mei* Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis. Oncogene 40: 2936-2951. (2021)
3. Kailiang Zhao, Decai Wang, Xiaolong Zhao, Chenfeng Wang, Yongxiang Gao, Kaiyue Liu, Fang Wang, Xianning Wu, Xuejuan Wang, Linfeng Sun, Jianye Zang and Yide Mei* WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function p53 in suppressing metastasis. EMBO Reports 21: e49269. (2020)
4. Chenfeng Wang#, Yang Yang#, Guang Zhang, Jingxin Li, Xianning Wu, Xiaoling Ma, Ge Shan and Yide Mei* Long non-coding RNA EMS connects c-Myc to cell cycle control and tumorigenesis. Proc Natl Acad Sci U S A 116: 14620-14629 (2019)
5. Kailiang Zhao, Yang Yang, Guang Zhang, Chenfeng Wang, Decai Wang, Mian Wu* and Yide Mei* Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7. EMBO Reports 19: 305-319. (2018)
6. Yang Yang, Chenfeng Wang, Kailiang Zhao, Guang Zhang, Decai Wang and Yide Mei* TRMP, a p53-inducible long noncoding RNA, regulates G1/S cell cycle progression by modulating IRES-dependent p27 translation. Cell Death & Disease 9: 886. (2018)
7. Hao Gu, Qidong Li, Shan Huang, Weiguang Lu, Fangyuan Cheng, Ping Gao, Chen Wang, Lin Miao*, Yide Mei* and Mian Wu*. Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling. Nat Commun 6: 7112. (2015)
8. Fan Yang, Huafeng Zhang, Yide Mei* and Mian Wu*. Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell 53: 88-100. (2014) (Highlighted in Science Signaling).
9. Xingwu Wang, Meng Zha, Xiaocheng Zhao, Peng Jiang, Wenjing Du, Andrew Y.H. Tam, Yide Mei* and Mian Wu*. Siva1 inhibits p53 function by acting as an E3 ubiquitin ligase of ARF. Nat Commun 4: 1551. (2013)
10. Xing Huang, Zhengsheng Wu, Yide Mei* and Mian Wu*. XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J 32: 2204-16. (2013) (Previewed in this issue).
11. Xingwu Wang, Xiaocheng Zhao, Xiang Gao, Yide Mei* and Mian Wu*. A new role of p53 in regulating lipid metabolism. J Mol Cell Biol. 5: 147-50. (2013)
12. Yide Mei#, Jeongsik Yong#, Hongtu Liu, Yigong Shi, Judy Meinkoth, Gideon Dreyfuss and Xiaolu Yang*. tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell 37: 668-78. (2010) (Cover story; Previewed in this issue; Highlighted in Science Signaling and Chemical & Engineering News).
Contact Information
Email: meiyide@ustc.edu.cn
Phone: 0551-63600921 (Office), 0551-63601270 (Lab)
Research ID: [http://www.researcherid.com/rid/M-4468-2013](http://www.researcherid.com/rid/M-4468-2013)