Contact Information
Fax:86-551-63600406
Educational Background
September 1980-July 1984, Bachelor's Degree, Department of Applied Physics, University of Science and Techlology of Harbin;
September 1987-May 1990, Master's Degree, Department of Applied Physics, University of Science and Technology of Harbin;
September 2000-September 2003, Doctor's Degree, University of Paris-Sud;
Main Work Experience
July 1984-September 1987, Teaching Assistant at the Department of Applied Physics, University of Science and Technology of Harbin;
May 1990-August 1998, Lecturer at the Department of Applied Physics, University of Science and Technology of Harbin;
August 1998-March 1999, Associate Professor at the Department of Applied Physics, University of Science and Technology of Harbin;
March 1999-March 2000, Visiting Scholar at the Institute of Nuclear Physics of National Center for Scientific Research;
September 2003-April 2004, Postdoctoral Fellow at the Institute of Enzymology and Biochemistry of National Center for Scientific Research;
June 2004-April 2007, Professor and PhD. supervisor at the Institute for Protein Research, School of Life Sciences and Technology, Tongji University;
Since April 2007, Working in University of Science and Technology of China
Selected Pubications
2) Wang J, Li X, Wang FF, Cheng MT, Mao YX, Fang SC, Wang L, Zhou CZ*, Hou WT*, Chen Y*. Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. EMBO Journal. 2023 Sep; 42(17):e113415.
3) Chen Y, Wang L, Hou WT, Zha ZH, Xu K, Zhou CZ*, Li Q*, Chen YX*. Structural insights into human ABCC4-mediated transport of platelet agonist and antagonist. Nature Cardiovascular Research. 2023 Jun; 2:693–701
4) Chen ZP, Xu D, Wang L, Mao YX, Li Y, Cheng MT, Zhou CZ*, Hou WT*, Chen Y*. Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nature Communications. 2022 Jun; 13(1):3299.
5) Wang L#, Hou WT#, *, Wang J, Xu D, Guo C, Sun LF, Ruan K, Zhou CZ*, Chen Y*. Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets. Cell Research. 2022 May; 32(5):501-504.
6) Xu D, Li YY, Yang FR, Sun CR, Pan JH, Wang L, Chen ZP, Fang SC, Yao XB, Hou WT*, Zhou CZ*, Chen Y*. Structure and Transport Mechanism of the Human Cholesterol Transporter ABCG1. Cell Reports. 2022 Jan; 38(4):110298.
7) Wang L#, Hou WT#, Chen L, Jiang YL, Xu D, Sun LF*, Zhou CZ*, Chen Y*. Cryo-EM structure of human bile salts exporter ABCB11. Cell Research. 2020 Jul; 30(7):623-625.
8) Xu D#, Feng Z#, Hou WT, Jiang YL, Wang L, Sun LF*, Zhou CZ*, Chen Y*. Cryo-EM structure of human lysosomal cobalamin exporter ABCD4. Cell Research. 2019 Dec; 29(12):1039-1041.
9) Yang HB#, Hou WT#, Cheng MT#, Jiang YL*, Chen Y*, Zhou CZ*. Structure of a MacAB-like efflux pump from Streptococcus pneumoniae. Nature Communications. 2018 January; 9(1):196.