Ph.D. Supervisor, Chief Physician, Professor, Director of Cardiology, one of the first academic and technical leaders in Anhui Province, Jianghuai Famous Doctor, Fellow of the American College of Cardiology (FACC), and member of the Society for Cardiovascular Angiography and Interventions (SCAI).
Education and Work Experience
1984-1989: Bachelor’s Degree, School of Medicine, Anhui Medical University
1989-1992: Resident Doctor, Department of Internal Medicine, Anhui Provincial Hospital
1992-1995: Master’s Degree, Cardiology, Tongji Medical College, Huazhong University of Science and Technology
1995-1999: Attending Physician, Department of Cardiology, Second Affiliated Hospital of Guangzhou Medical University
1999-2000: Associate Chief Physician and Deputy Director, Department of Cardiology, Anhui Provincial Hospital
2002: Advanced training in interventional treatment of coronary heart disease, National Heart Centre, Singapore
2004: Short-term professional study in Australia, sponsored by Anhui Provincial Personnel Department
April-June 2005: Advanced training in new interventional techniques for coronary heart disease, Bad Berka Central Hospital, Germany
2006: Promoted to Chief Physician by special approval
2007: Promoted to Professor
2010: Ph.D. in Internal Medicine, Huazhong University of Science and Technology
2018-2019: Deputy Director and Subspecialty Director, Department of Cardiology, First Affiliated Hospital of the University of Science and Technology of China
January 2020-present: Director, Department of Cardiology, First Affiliated Hospital of the University of Science and Technology of China
Academic Achievements and Impact
Dedicated to the interventional diagnosis and treatment of coronary heart disease, Dr. Ma is a national-level mentor for interventional training. He is Vice Chairman of the China Chest Pain Center Alliance, an expert in the Coronary Heart Disease Expert Working Group of the National Cardiovascular Disease Quality Control Center, Executive Chairman of the Anhui Province Chest Pain Alliance, Deputy Director of the Anhui Cardiovascular Disease Quality Control Center, and Chairman of the Cardiovascular Disease Professional Committee of the Anhui Society of Pathophysiology. He also serves in various capacities in national medical associations.
Dr. Ma has received the Second Prize of Anhui Provincial Science and Technology Progress Award once and the Third Prize twice, and he was awarded the 10th Anhui Youth Science and Technology Award. He has led over 10 provincial and ministerial research projects and published more than 160 academic papers, as well as authored two academic monographs.
Ongoing Projects (as Principal Investigator)
Study on the Molecular Mechanism and Regulation of Periostin-Mediated Macrophage Polarization in PDGFs/PDGFRs Signaling Pathway in Myocardial Fibrosis (No. 81870192), National Natural Science Foundation of China, 5.7 million RMB, 2018-2022
Promotion and Application of Coronary Rotational Atherectomy in Treating Severe Coronary Calcification (No. J2019Y02), Hefei Science and Technology Bureau, 10 million RMB, 2019-2022
Main Research Directions (Graduate Programs) and Content
Clinical Medicine
Internal Medicine (Cardiovascular)
Myocardial fibrosis
Cardiac aging
Myocardial ischemia-reperfusion injury
Interventional diagnosis and treatment of cardiovascular diseases
Representative Papers (Last Five Years)
1. Beilei Wang , Jinsheng Hua, Renchuan You, Kun Yan, Likun Ma*. Electrochemically deposition of catechol-chitosan hydrogel coating on coronary stent with robust copper ions immobilization capability and improved interfacial biological activity. Int J Biol Macromol, 2021 Mar 26;S0141-8130(21)00702-9. doi: 10.1016/j.ijbiomac.2021.03.158.
2. Zheng Gong, Qing Ye, Jia-Wei Wu, Jun-Ling Zhou, Xiang-Yong Kong, Li-Kun Ma*. UCHL1 inhibition attenuates cardiac fibrosis via modulation of nuclear factor-<kappa>B signaling in fibroblasts. Eur J Pharmacol. 2021 Mar 18:174045. doi: 10.1016/j.ejphar.2021.174045.
3. Hongwu Chen, Xiaofan Yu, Likun Ma*. Risk Factors of Contrast Induced Nephropathy in Patients with STEMI and Pump Failure undergoing either Primary Percutaneous Coronary Intervention or Elective Percutaneous Coronary Intervention: Findings from the Improving Care for Cardiovascular Disease Project in China. Experimental and Therapeutic Medicine.2021;21(2): doi: 10.3892/etm.2020.9572.
4. Xudong Zhu, Weiyan Shen, Zhu Liu, Shihao Sheng, Wei Xiong, Ruikun He, Xuguang Zhang, Likun Ma*, Zhenyu Ju. Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice. Front Cell Dev Biol, 2021; 8: 1739.
5. Dan Li, Wen Jin, Li Sun, Jiawei Wu, Hao Hu and Likun Ma*. Circ_0065149 Alleviates Oxidized Low-Density Lipoprotein-InducedApoptosis and Inflammation in Atherosclerosis by Targeting miR-330-5p. Front Genet, 2021; 12
6. Jia-Wei Wu, Hao Hu, Dan Li, Li-Kun Ma*. Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury. AGING 2020；13(3):3443-3458.
7. Qing Ye, Jie Zhang, Likun Ma*. Predictors of all-cause 1-year mortality in myocardial infarction patients. Medicine (Baltimore).2020 Jul 17 ;99(29) :e21288.
8. Hongwu Chen, Xiaofan Yu, Xiangyong Kong, Longwei Li, Jiawei Wu, Likun Ma*. Predictive value of ACEF score for clinical prognosis of elderly patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention. Annals of Palliative Medicine. 2020 Oct 20;apm-20-591.
9. Hao Hu, Jiawei Wu, Xiaofan Yu, Junling Zhou, Likun Ma*. Long noncoding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy modulation. Biochem Cell Biol. 2020;98(2):130-136.
10. Hao Hu, Jiawei Wu, Cheng Chao, Likun Ma*. Exosomes derived from regulatory T cells ameliorate acute myocardial infarction by promoting macrophage M2 polarization. IUBMB Life 2020;72(11):2409-2419.
11、. Junling Zhou, Longwei Li, Hao Hu, Jiawei Wu, Hongwu Chen, Kefu Feng, Likun Ma*. Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101. J Cardiovasc Pharmacol. 2020; 76(4): 427-436.
12. Dongbiao YU, Likun MA*, Junling ZHOU, Longwei LI, Wu YAN and Xiaofen YU. Influence of CYP2C19 genotype on antiplatelet treatment outcomes after percutaneous coronary intervention in patients with coronary heart disease. EXPERIMENTAL AND THERAPEUTIC MEDICINE 19: 3411-3418, 2020
13. Jinsheng Hua, Haining You, Xiufang Li, Renchuan You, Likun Ma*. Cu(II) ion loading in silk fibroin scaffolds with silk I structure. International Journal of Biological Macromolecules 2020,158:275–281.
14. WEI CAO， LIKUN MA*. Curative effect of β-blocker on various ejection fractions of patients with atrial fibrillation. Exp Ther Med.2019 Aug;18(2):1149-1154.
15. Jiawei Wu, Hao Hu, Dan Li, Likun Ma*. In-hospital outcomes of delayed stenting in hemodynamically stable patients with ST-segment elevation myocardial infarction: the CCC (Care for Cardiovascular Disease in China) project. Cardiovasc Diagn Ther 2019; 9:462-471.
16. Zhou Junling, Li Longwei, Hao Hu, Jiawei Wu, Hongwu Chen, Kefu Feng, Likun Ma*. Clinical efficacy of clopidogrel combined with aspirin for acute myocardial infarction and its effects on HS-CRP, NT-proBNP, CTNI, ET and MMP-9 levels. Acta Medica Mediterranea 2019, 35: 2345-2349.
17. Hao Hu, Jiawei Wu, Xiaofan Yu, Hua Yu, Likun Ma*. Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling. Biol Res 2019;52:58.
18. Hu hao, Wu jiawei, Li dan, Zhou junling, Yu hua, Ma Likun*. Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis. Biomed Pharmacother. 2018 Oct;106:738-746
19. Han zhang Wang, LiKun Ma*, Lei Wang, Long wei Li, Jia wei Wu. PDGF-CC induced rat myocardial fibrosis is mediated by ERK1/2 signaling pathway and potential mechanism[J]. International Journal of Clinical and Experimental Medicine. 2017;10(12):16344-16351.
20. Lei Wang, LiKun Ma*, Hai Fan, Zhe Yang, LongWei Li, HanZhang Wang. MicroRNA-9 regulates cardiac fibrosis by targeting PDGFR-β in rats. J Physiol Biochem, 2016; 72:213–223.
Contact Information
Email: lkma@ustc.edu.cn, lkma119@163.com
Phone: 18756967633 / 0551-62284055