PhD Supervisor, Chief Physician, Postdoctoral Mentor, Administrative Director of the Hematology Department at the First Affiliated Hospital of the University of Science and Technology of China (USTC), Deputy Director of the Hematology and Cell Therapy Research Institute at USTC, Reserve Candidate for Academic and Technical Leaders in Anhui Province, and a Distinguished Young Technical Talent in the Second Cohort at Anhui Provincial Hospital. Studied at the University of Maryland, USA, and the University of Toronto, Canada.
Academic Positions
- Member of the 11th Committee of the Hematopoietic Stem Cell Application Group, Chinese Society of Hematology
- Member of the 9th and 10th Youth Committees, Chinese Society of Hematology
- Deputy Director of the 7th Youth Committee, Anhui Province Hematology Society
- Member of the 1st Committee, Hematology Branch, China International Exchange and Promotive Association for Medical and Health Care
- Member of the Umbilical Cord Blood Application Professional Committee, China Maternal and Child Health Association
Education and Work Experience
- 1999-2004: Bachelor’s degree in Clinical Medicine, Sun Yat-sen University
- 2004-2009: Combined Master's and PhD in Internal Medicine, Hematology, Sun Yat-sen University
- 2009-2010: Resident Physician, Hematology Department, Anhui Provincial Hospital
- 2010-2013: Chief Resident and Attending Physician, Hematology Department, Anhui Provincial Hospital
- 2013-2018: Associate Chief Physician, Hematology Department, Anhui Provincial Hospital
- 2018-Present: Chief Physician, Hematology Department, First Affiliated Hospital of USTC
Academic Achievements and Impact
Focused on the diagnosis and treatment of malignant hematological diseases and hematopoietic stem cell transplantation, especially unrelated umbilical cord blood transplantation. Supervised 2 PhD and 3 Master's students. Published research in journals such as Blood Advances, Bone Marrow Transplantation, and Biol Blood Marrow Transplant.
Ongoing Projects (Principal Investigator Only)
Project Name, Source, Funding Indicator Number | Total Funding (10,000 CNY) | Start-End Date
1. Study on the Mechanism of rhTPO Activating TPO/c-MPL Signaling Pathway to Promote Platelet Engraftment and Enhance Graft-Versus-Leukemia Effect after Unrelated Umbilical Cord Blood Transplantation, 2019 New Medicine Key Project | 80 | 2019-07 to 2022-06
2. Research on Immune Reconstitution Patterns after Unrelated Umbilical Cord Blood Transplantation, 2021 USTC Youth Innovation Fund | 20 | 2021-01 to 2022-12
3. Study on the Mechanism of NKG2D and DNAM-1 Signaling Pathways Combined with Gene Screening in Double-Negative T Cell Therapy for Relapsed AML Patients after UCBT, National Natural Science Foundation Project | 55 | 2017-01 to 2021-12
Main Research Directions (Enrollment Specialties) and Content
Biology
1. Cell Biology
- Study and clinical translation of the biological characteristics of double-negative T (DNT) cells
- In vitro expansion of hematopoietic stem cells and differentiation of megakaryocytes
Clinical Medicine
1. Hematology/Hematopoietic Stem Cell Transplantation
- Research on hematopoietic and immune reconstitution after stem cell transplantation
- Research on relapse after hematopoietic stem cell transplantation
Representative Papers (Last Five Years)
1. Zhu X#*, Tang B#, Sun Z*. Umbilical cord blood transplantation: Still growing and improving. Stem Cells Translational Medicine. 2021. (Accepted)
2. Tang B#, Huang L#, Liu H, et al. Recombinant human thrombopoietin promotes platelet engraftment after umbilical cord blood transplantation. Blood Adv. 2020;4(16):3829-3839.
3. Tang B#, Zhu X#, Zheng C, et al. Retrospective cohort study comparing the outcomes of intravenous busulfan vs. total-body irradiation after single cord blood transplantation. Bone Marrow Transplant. 2019;54(10):1614-1624.
4. Zhu X#, Huang L#, Zheng C, et al. European Group for Blood and Marrow Transplantation Risk Score Predicts the Outcome of Patients with Acute Leukemia Receiving Single Umbilical Cord Blood Transplantation. Biol Blood Marrow Transplant. 2017;23(12):2118-2126.
5. Zhu X#, Liu X#, Cheng Z, et al. Quantitative analysis of global proteome and lysine acetylome reveal the differential impacts of VPA and SAHA on HL60 Cells. Sci Rep. 2016;6:19926.
6. Tang B#, Zhu X#, Zheng C, et al. Successful early unmanipulated haploidentical transplantation with reduced-intensity conditioning for primary graft failure after cord blood transplantation in hematologic malignancy patients. Bone Marrow Transplant. 2015;50(2):248-252.
Contact Information
E-mail: xiaoyuz@ustc.edu.cn
Phone: 0551-62284831