Education and Work Experience
- 1994–1997: Master's in Immunology, Shandong Academy of Medical Sciences
- 2000–2003: Ph.D. in Internal Medicine (Hematology), Soochow University
- 2004–2014: Post-Doctoral/Research Associate, University of Oklahoma Health Sciences Center
- 2015–2016: Assistant Professor, Georgia State University
- 2017–2021: Director, Central Laboratory/Experimental Hematology Subspecialty, First Affiliated Hospital of the University of Science and Technology of China
Academic Achievements and Impact
Dedicated to teaching and research in hematology for over 20 years, Zhu has supervised 10 Ph.D. and master's students and received multiple provincial science and technology progress awards.
1. Discovered that AMPK regulates erythrocyte maturation and function through the mitochondrial autophagy pathway. AMPK deficiency leads to severe hemolytic anemia, elucidating a new pathogenesis of hemolytic anemia and providing new therapeutic approaches.
2. Demonstrated that AMPK is essential for monocyte-macrophage survival and function, revealing its role in the development of atherosclerosis. Targeting AMPK activation could benefit the treatment of ischemic diseases.
Published over 20 papers in SCI journals such as *CMI*, *Blood*, *Autophagy*, *ATVB*, and *J. Biol. Chem.*
Ongoing Projects (Limited to Principal Investigator)
- Project Name: Mechanism of AMPK Regulating Treg Cell Function through Phosphorylation of FOXP3
- Source: National Natural Science Foundation of China General Program, 31870897
- Total Funding: 580,000 RMB
- Duration: 2019-01 to 2022-12
Primary Research Areas (Graduate Programs) and Content
Biology
- Cell Biology
1. Research on the mechanisms of hematopoiesis and regulation, and clinical applications.
2. Mechanisms of regulatory T/B cells in the occurrence of GVHD.
Clinical Medicine
- Hematology
1. Investigation of immune reconstitution patterns post-hematopoietic stem cell transplantation.
2. Research on the separation mechanisms of GVHD and GVL post-hematopoietic stem cell transplantation and clinical applications.
Representative Papers (Last Five Years)
1. Huaiping Zhu, Zhaoyu Liu, Junqing An, Miao Zhang, Yu Qiu & Ming-Hui Zou. Activation of AMPKα1 is essential for regulatory T cell function and autoimmune liver disease prevention. Cellular & Molecular Immunology. 2021;18: 2609–2617
2. Xianghui Du,Huaiping Zhu*, Defeng Jiao, Zhigang Nian, Jinghe Zhang, Yonggang Zhou, Xiaohu Zheng, Xianhong Tong, Haiming Wei and Binqing Fu. Human-Induced CD49a+ NK Cells Promote Fetal Growth. Frontiers in Immunology.2022;13:821542
3. Liuyu Xie, Beng Wu, Yuanyuan Fan, Ye Tao,Xiaoyong Jiang,Qing Li,| Huaiping Zhu*, Hua Wang, Chaojie Hu. Fatty acid synthesis is indispensable for Kupffer cells to eliminate bacteria in ALD progression. Hepatology Communications. 2024;8:e0522
4. Dongyao Wang, Zimin Sun, Xiaoyu Zhu, Xiaohu Zheng,Yonggang Zhou, Huilan Liu, Huaiping Zhu, Rui Sun, Yi Wang, Binqing Fu, Zhigang Tian, Haiming Wei. GARP-mediated active TGF-β1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT. Blood. 2022; 29;140(26):2788-2804.
Contact Information
E-mail: huaipingzhu@ustc.edu.cn
Phone: 0551 62283574