Professor, Chief Physician, Ph.D. Supervisor. Currently serves as Vice President of the Clinical Medical College and the First Affiliated Hospital of the University of Science and Technology of China, and Director of the Neurology Institute at Nanjing University.
With over 30 years dedicated to neurology, cerebrovascular disease, and interventional diagnosis and treatment in clinical practice, teaching, and research. Selected for the National Millions of Talents Project and recognized as an Outstanding Scientific Worker. Recipient of the State Council Special Allowance.
As the primary contributor, received one National Science and Technology Progress Second Prize and five provincial and ministerial first prizes. Published over 300 SCI papers as the first or corresponding author in journals such as the New England Journal of Medicine, Lancet, Lancet Neurology, Journal of Clinical Investigation, Nature Communications, Neurology, and Stroke. Holds over 10 national patents. Led more than 30 projects, including major international collaborations and national key R&D projects. Spearheaded the development of 14 guidelines or expert consensus documents on interventional diagnosis and treatment of cerebrovascular diseases in China.
Holds academic positions such as Chairman of the Interventional Neurology Committee of the Chinese Research Hospital Association, Standing Committee Member of the Neurology Division of the Chinese Medical Doctor Association, Chairman of the Neurological Intervention Committee, and Leader of the Neurological Vascular Intervention Collaboration Group of the Chinese Medical Association Neurology Branch.
Main Research Areas (Recruitment Fields) and Content
Clinical Medicine, Neurology
1. Interventional diagnosis and treatment of cerebrovascular diseases
2. AI-assisted diagnosis and clinical prognosis of cerebrovascular diseases
3. Translational medical research on neurological diseases
Representative Papers
1. Tao C, Nogueira RG#, Zhu Y#, Sun J, Han H#, Yuan G, Wen C, Zhou P, Chen W, Zeng G, Li Y, Ma Z, Yu C, Su J, Zhou Z, Chen Z, Liao G, Sun Y, Ren Y, Zhang H, Chen J, Yue X, Xiao G, Wang L, Liu R, Liu W, Liu Y, Wang L, Zhang C, Liu T, Song J, Li R, Xu P, Yin Y, Wang G, Baxter B, Qureshi AI, Liu X*, Hu W*; ATTENTIONInvestigators. Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion. N Engl J Med. 2022 Oct 13;387(15):1361-1372. IF 176.079
2. Liu X*, Dai Q, Ye R, Zi W, Liu Y, Wang H, Zhu W, Ma M, Yin Q, Li M, Fan X, Sun W, Han Y, Lv Q, Liu R, Yang D, Shi Z, Zheng D, Deng X, Wan Y, Wang Z, Geng Y, Chen X, Zhou Z, Liao G, Jin P, Liu Y, Liu X, Zhang M, Zhou F, Shi H, Zhang Y, Guo F, Yin C, Niu G, Zhang M, Cai X, Zhu Q, Chen Z, Liang Y, Li B, Lin M, Wang W, Xu H, Fu X, Liu W, Tian X, Gong Z, Shi H, Wang C, Lv P, Tao Z, Zhu L, Yang S, Hu W, Jiang P, Liebeskind DS, Pereira VM, Leung T, Yan B, Davis S, Xu G, Nogueira RG*; BEST Trial Investigators. Investigators† Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurology. 2020 Feb;19(2):115-122. IF 59.935
3. Xie Y, Zhang X#, Xu P#, Zhao N, Zhao Y, Li Y, Hong Y, Peng M, Yuan K, Wan T, Sun R, Chen D, Xu L, Chen J, Guo H, Shan W, Li J, Li R, Xiong Y, Liu D, Wang Y, Liu G, Ye R*, Liu X*. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia. J Clin Invest. 2021 Jan 4;131(1):e128114. doi: 10.1172/JCI128114. IF 19.456
4. Zhao Y#, Zhu W#, Wan T#, Zhang X, Li Y, Huang Z, Xu P, Huang K, Ye R*, Xie Y*, Liu X*. Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice. Nat Commun. 2022 Nov 10;13(1):6813. IF 17.694
5. Wan T, Zhu W#, Zhao Y#, Zhang X, Ye R, Zuo M, Xu P, Huang Z, Zhang C, Xie Y*, Liu X*. Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice. Nat Commun. 2022 Mar 3;13(1):1134. IF 17.694
6. Liu R, Yin Q, Li M, Ye R, Zhu W, Liu X*. Diagnosis and treatment evaluation of in-stent restenosis of carotid artery stenting using optical coherence tomography. Neurology. 2019 Jan 8;92(2):99-100. IF 11.8
7. Wang J, Li F, Xiao L, Peng F, Sun W*, Li M, Liu D, Jiang Y, Guo R, Li H, Zhu W, Xu G, Liu X*. Depressed TSH level as a predictor of poststroke fatigue in patients with acute ischemic stroke.Neurology. 2018 Nov 20;91(21):e1971-e1978. IF 11.8
8. Xiao L, Ma M#, Gu M, Han Y, Wang H, Zi W, Yang D, Hao Y, Lv Q, Ye R, Sun W*, Zhu W, Xu G, Liu X*; ACTUAL Investigators. Renal impairment on clinical outcomes following endovascular recanalization. Neurology. 2020 Feb 4;94(5):e464-e473. IF 11.8
9. Dai Q, Sun W#, Xiong Y, Hankey GJ, Xiao L, Zhu W, Ma M, Liu W, Liu D, Cai Q, Han Y, Duan L, Chen X, Xu G, Liu X*. From clinical to tissue-based dual TIA: Validation and refinement of ABCD3-I score. Neurology. 2015 Apr 7;84(14):1426-32. IF 11.8
10. Yuan K, Chen J, Xu P, Zhang X, Gong X, Wu M, Xie Y, Wang H, Xu G, Liu X*. A Nomogram for Predicting Stroke Recurrence Among Young Adults. Stroke. 2020 Jun;51(6):1865-1867. IF 10.17
11. Xiao L, Lan W, Sun W, Dai Q, Xiong Y, Li L, Zhou Y, Zheng P, Fan W, Ma N, Guo Z, Chen X, Xie X, Xu L, Zhu W*, Xu G, Liu X*. Chronic Kidney Disease in Patients With Lacunar Stroke: Association With Enlarged Perivascular Spaces and Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease. Stroke. 2015 Aug;46(8):2081-6. IF 10.17
Ongoing Projects (Main Leader Only)
- National Natural Science Foundation (Joint Fund Project): Mechanisms and Intervention Strategies of Oligodendrocyte Involvement in Plateau Environment-Induced Cerebral Ischemic Injury, Code U22A20341, Total Funding: 2.55 million RMB, 2023.01-2026.12
- National Natural Science Foundation (Joint Fund Project): Intelligent Comprehensive Assessment and Risk Prediction of Intracranial and Extracranial Large Artery Stenosis, Code U20A20357, Total Funding: 2.6 million RMB, 2021.01-2024.12
- Jiangsu Key R&D Program (Clinical Frontier Technology Project): New Strategy for Assessing Cerebral Artery Stenosis Based on Deep Learning, Code BE2020700, Total Funding: 2 million RMB, 2020.07-2023.06