Born in May 1966, MD, PhD supervisor, Chief Physician, Deputy Director of the Anesthesiology Department at the First Affiliated Hospital of the University of Science and Technology of China (USTC). She is an Executive Committee Member of the Anesthesiology Physicians Branch of the Chinese Medical Doctor Association, Deputy Chair of the Thoracic Division of the Chinese Society of Cardiothoracic and Vascular Anesthesia, Standing Committee Member of the Anesthesia Professional Committee of the Chinese Medical Education Association, and the Anesthesia and Brain Function Branch of the Chinese Neuroscience Society. She serves on the editorial boards of the Chinese Journal of Anesthesiology and the Journal of Clinical Anesthesiology. In 2019, she was awarded the title of Seventh Provincial Academic and Technical Leader and received one Second Prize and five Third Prizes for Scientific and Technological Progress in Anhui Province. As a clinician, she has consistently focused on integrating clinical practice with basic research, publishing over 100 papers, including 40 SCI papers, with major findings published in journals such as Nature Neuroscience and Neuropeptides.
Education and Work Experience
- 1984-1989: Bachelor of Medicine, Anhui Medical University
- 1997-2000: Master's in Pharmacology, Anhui Medical University
- 2003-2008: PhD in Pharmacology, Anhui Medical University
- 1989-1994: Resident Physician, Anesthesiology Department, Anhui Provincial Hospital
- 1995-2002: Attending Physician, Anesthesiology Department, Anhui Provincial Hospital
- 2002-2010: Associate Chief Physician, Anesthesiology Department, Anhui Provincial Hospital
- 2010-Present: Chief Physician, Anesthesiology Department, Anhui Provincial Hospital
- 2010-Present: Deputy Director, Anesthesiology Department, First Affiliated Hospital of USTC
Academic Achievements and Impact
With over 30 years in clinical anesthesia, Dr. Li has consistently integrated clinical and basic research, supervising 8 PhD and 15 Master's students. She has received one Second Prize and five Third Prizes for Provincial Scientific and Technological Progress.
In the past five years, she has published over 14 papers as a corresponding author in journals like Nature Neuroscience.
Current Research Projects (Main Responsible Person Only)
- Project Title: Role and Mechanism of the Delta Opioid System in Bone Cancer Pain Relief
Source: USTC New Medicine Key Project
Funding: 800,000 RMB
Duration: 2019-12 to 2022-12
- Project Title: Epigenetic Mechanisms of SIRT1 in Bone Cancer Pain
Source: Anhui Provincial Natural Science Foundation
Funding: 100,000 RMB
Duration: 2019-12 to 2022-12
Main Research Directions (Admissions Major) and Content
Clinical Medicine
1. Clinical Research
- Protection of vital organs during the perioperative period
- Effects of transcutaneous acupoint electrical stimulation on perioperative complications
2. Basic Research
- Mechanisms of ischemia-reperfusion injury in the brain and kidneys
- Analgesic mechanisms of δ-opioid receptors in cancer pain
- Specific neural circuits involved in pain from different causes
Representative Papers (Last Five Years)
1、Xia Zhu#, Hao-Di Tang#,Wan-Ying Dong#, Fang Kang#, An Liu, Yu Mao，Wen Xie, Xulai Zhang, Peng Cao, Wenjie Zhou, Haitao Wang, Zahra Farzinpour, Wenjuan Tao, Xiaoyuan Song, Yan Zhang, Tian Xue, Yan Jin, Juan Li,and Zhi Zhang. Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nature Neuroscience, https://doi.org/10.1038/s41593-021-00811-x，2021.
2、Chengwei Yang, Fang Kang , Wenjun Meng, Meirong Dong, XiangHuang, Sheng Wang, Zhiyi Zuo, Juan Li. Minimum alveolar concentration-awake of sevoflurane is decreased in patients with Parkinson’s disease: an up-and-down sequential allocation trial. Clinical Interventions in Aging, 2021:16 129–137.
3、Han M, Kang F, Yang C, Liu Z, Wang T, Zhai M, Li J. Comparison of Adrenaline and Dexmedetomidine in Improving the Cutaneous Analgesia of Mexiletine in Response to Skin Pinpricks in Rats[J]. Pharmacology 2020:1-7.
4、Chengwei Yang, Yuanyuan Feng, Sheng Wang, Mingming Han, Song Wang, Fang Kang, Xiang Huang, Juan Li, Effect of sex differences in remifentanil requirements for inhibiting the response to a CO2 pneumoperitoneum during propofol anesthesia: an up-and-down sequential allocation trial, BMC Anesthesiol, 2020 Feb 3;20(1):35.
5、Yang C#, Huang X#, Wang S, Han M, Kang F, Zhang Z, Li J. Intrathecal administration of SRT1720 relieves bone cancer pain by inhibiting the CREB/CRTC1 signalling pathway. Neuroscience letters 2020; 715: 134623.
6、Lingsuo Kong,Qing Wei，Xianwen Hu，Lanren Chen， Juan Li，miR-193a-3p Promotes Radio-Resistance of Nasopharyngeal Cancer Cells by Targeting SRSF2 Gene and Hypoxia Signaling Pathway，Med Sci Monit Basic Res, 2019；25:53-62
7、Chengwei Yang, Fang Kang, Sheng Wang, Mingming Han, Zhi Zhang, Juan Li. SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5, Cellular and molecular neurobiology, 2019 Nov;39(8):1165-1175
8、Xi bei Hu, Zhi yu Xi, Lin qing Liu, Kai Kang, Wan hong Li, Yu xian Shen, Fang Kang, Juan Li. Dexmedetomidine Promotes SH-SY5Y Cell Resistance Against Impairment of Iron Overload by Inhibiting NF-κB Pathways.Neurochemical Research, 29 January 2019, 44(4)： 959-967.
9、Mingming Han, Fushan Xue, Fang Kang, Xiang Huang, Juan Li.Male requires a higher median target effect-site concentration of propofol for I-gel placement when combined with dexmedetomidine, Anaesth Crit Care Pain Med 2019 Feb;38(1):57-61.
10、Qijian Li, Chaojin Chen, Xi Chen, Mingming Han, Juan Li. Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senscence after renal ischema/reperfusion. Life Sci. 2018, 207:1-8.
11、Fang Kang, ChaoLiang Tang MingMing Han, XiaoQing Chai, Qiang Huang, Juan Li. Effects of Dexmedetomidine-Isoflurane versus Isoflurane Anesthesia on Brain Injury After Cardiac Valve Replacement Surgery. J Cardiothorac Vasc Anesth. 2018 Aug;32(4): 1581-1586.
12、Ming-Ming Han, Cheng-Wei Yang, Chi-Wai Cheung, Juan Li. Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice. Neuropeptides, 2018; 68: 36-42.
13、Jia Yang, Zhijun Chen, Xinyi Wang, Mo Xu, Haoshu Fang, Feifei Li, Yakun Liu,Yu Jiang, Yi Ding, Juan Li& Siying Wan. Inactivation of miR-100 combined with arsenic treatment enhances the malignant transformation of BEAS-2B cells via stimulating epithelial -mesenchymal transition. Cancer Biology & Therapy, 2017, VOL. 18, NO. 12, 965–973.
14、Mingyu Zhai, MM, Fang Kang, MD, Mingming Han,MM, Xiang Huang, MM, Juan Li, PhD. The effect of dexmedetomidine on renal function in patients undergoing cardiac valve replacement under cardiopulmonary bypass: A double-blind randomized controlled trial. Journal of Clinical Anesthesia 40 (2017) 33–38.
Contact Information
E-mail: huamuzi1999@126.com
Phone: 0551-62284460