Education and Work Experience
- 1994-1997: Anhui University of Traditional Chinese Medicine, Clinical Medicine
- 2003-2006: Xuzhou Medical University, Anesthesiology, Master's
- 2013-2016: Huazhong University of Science and Technology, Anesthesiology, PhD
- 1997-2003: Shouxian Traditional Chinese Medicine Hospital, Anesthesiology Department, Resident Physician
- 2006-2011: First Affiliated Hospital of Shihezi University School of Medicine, Anesthesiology Department, Attending Physician/Lecturer
- 2011-2016: First Affiliated Hospital of Shihezi University School of Medicine, Anesthesiology Department, Associate Chief Physician/Associate Professor
- 2016-2018: First Affiliated Hospital of Shihezi University School of Medicine, Anesthesiology Department, Chief Physician/Professor
- 2018-present: First Affiliated Hospital of University of Science and Technology of China, Anesthesiology Department, Chief Physician/Professor
Academic Achievements and Impact
Dedicated to anesthesia teaching and research for over 20 years, supervised 2 PhD and over 20 master's students. Academic positions include: Member of the 12th and 13th Committees of the Chinese Society of Anesthesiology, Standing Committee Member of the Daytime Anesthesia Branch of the Chinese Society of Cardiothoracic and Vascular Anesthesia, Member of the Anesthesiology Committee of the Chinese Research Hospital Association, Deputy Chairman of the Anesthesiology Branch of the Anhui Medical Association, Editorial Board Member of the International Journal of Anesthesiology and Resuscitation, Corresponding Editorial Board Member of the Journal of Clinical Anesthesiology. Led 2 National Natural Science Foundation projects, received 2 provincial science and technology progress awards, published over 60 papers, with more than 20 SCI-indexed papers as the first or corresponding author, cited over 400 times, authored 2 monographs, and obtained 9 utility model patents.
Ongoing Projects (as Principal Investigator)
1. Role of MEF2 in Transcriptional Regulation of TGF-β in Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury, National Natural Science Foundation Regional Project
- Total Funding: ¥370,000
- Duration: 2019-01 to 2022-12
2. Neuro-Molecular Mechanism Study of Isoflurane on Neurological Function During Chronic Recovery of Ischemic Stroke, Wu Jieping Foundation Project
- Total Funding: ¥300,000
- Duration: 2021-01 to 2023-12
3. Study on Lung Protection in High-Risk Patients Undergoing Elective Thoracoscopic Surgery with Glycopyrronium Bromide, Beijing Ronghe Medical Development Foundation Project
- Total Funding: ¥100,000
- Duration: 2021-01 to 2023-12
Main Research Directions (Recruiting Disciplines) and Content
Biology
1. Neurobiology
- Mechanism of Cerebral Ischemia-Reperfusion Injury
- Neural Circuit Mechanisms in Recovery from Ischemic Encephalopathy
Clinical Medicine
1. Anesthesiology
- Signal Transduction Mechanisms of Central Effects of General Anesthetics
- Role and Mechanism of TGF-β Pathway in Central Nervous Protection by Inhalation Anesthetics
- Organ Protection in Critically Ill Patients During Perioperative Period
- Pathophysiological Mechanisms Related to Clinical Anesthesia
Representative Papers (Last Five Years)
1. Zhang Q, Yin J, Xu F, Zhai J, Yin J, Ge M, Zhou W, Li N, Qin X, Li Y, Wang S. Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway. J Cell Mol Med. 2021 Apr;25(8):3803-3815. doi: 10.1111/jcmm.16282. Epub 2021 Feb 23.2.
2. Feng Xu,Qingtong Zhang,Jiangwen Yin, Mingyue Ge, Erfeng Xiong, Hong He, Sheng Wang, Guixing Zhang, Shiwen Fan. Sex difference in preoperative stress and sleeping duration related to the variation of preoperative heart rate and systolic blood pressure. Journal of clinic anesthesia.60,2020,101-102
3. Xu F, Yin J, Xiong E, Wang R, Zhai J, Xie L, Li Y, Qin X, Wang E, Zhang Q, Zuo Y, Fan S, Wang S. COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity. Mol Pain. 2020 Jan-Dec;16:1744806920908474. doi: 10.1177/1744806920908474.
4. Xu F, Yin JW, Xiong EF, He H, Zhang QT, Fan SW, Qin XL, Wang S.
Correlation between Preoperative Anxiety and ABO Blood Types: Evidence from a Clinical Cross-Sectional Study. Dis Markers. 2019 Dec 2;2019:1761693. doi: 10.1155/2019/1761693. eCollection 2019. PMID: 31871497 Free PMC article. Clinical Trial.
5. Peng L, Yang C, Yin J, Ge M, Wang S, Zhang G, Zhang Q, Xu F, Dai Z, Xie L, Li Y, Si JQ, Ma K. TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats. Front Neurosci. 2019 Jun 26;13:636. doi: 10.3389/fnins.2019.00636. eCollection 2019. PMID: 31297044.
6. Peng L, Yin J, Ge M, Wang S, Xie L, Li Y, Si JQ, Ma K. Isoflurane Post-conditioning Ameliorates Cerebral Ischemia/Reperfusion Injury by Enhancing Angiogenesis Through Activating the Shh/Gli Signaling Pathway in Rats. Front Neurosci. 2019 Apr 9;13:321. doi: 10.3389/fnins.2019.00321. eCollection 2019. PMID: 31024240.
7. Xu F, Zhang G, Yin J, Zhang Q, Ge MY, Peng L, Wang S, Li Y. Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus.
Behav Brain Res. 2019 Sep 16;370:111952. doi: 10.1016/j.bbr.2019.111952. Epub 2019 May 17. PMID: 31103751.
8. Peng L, Yin J, Wang S, Ge M, Han Z, Wang Y, Zhang M, Xie L, Li Y. TGF-β2/Smad3 Signaling Pathway Activation Through Enhancing VEGF and CD34 Ameliorates Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats. Neurochem Res. 2019 Nov;44(11):2606-2618. doi: 10.1007/s11064-019-02880-8. Epub 2019 Sep 25. PMID: 31555994.
9. Yang Y, Chen L, Si J, Ma K, Yin J, Li Y, Yang C, Wang S. TGF-β3/Smad3 Contributes to Isoflurane Postconditioning Against Cerebral Ischemia-Reperfusion Injury by Upregulating MEF2C. Cell Mol Neurobiol. 2020 Nov;40(8):1353-1365. doi: 10.1007/s10571-020-00822-5. Epub 2020 Mar 4. PMID: 32130571.
10. Yin JW, Li J, Ren YM, Li Y, Wang RX, Wang S, Zuo YX. Dexmedetomidine and Netrin-1 Combination Therapy Inhibits Endoplasmic Reticulum Stress by Regulating the ERK5/MEF2A Pathway to Attenuate Cerebral Ischemia Injury. Front Neurosci. 2021 Jan 28;15:641345. doi: 10.3389/fnins.2021.641345. eCollection 2021. PMID: 33584197.
11. Zhang G, Ge M, Han Z, Wang S, Yin J, Peng L, Xu F, Zhang Q, Dai Z, Xie L, Li Y, Si J, Ma K. Wnt/β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway. Biomed Pharmacother. 2019 Feb;110:420-430. doi: 12.1016/j.biopha.2018.11.143. Epub 2018 Dec 5. PMID: 30530044
Contact Information
E-mail: iamsheng2020@ustc.edu.cn
Phone: 0551-62282052