Ph.D. Supervisor, Chief Physician, and Professor. Head of Neurosurgery at the First Affiliated Hospital of the University of Science and Technology of China (USTC), Deputy Director of the Anhui Institute of Stereotactic Neurosurgery, and Director of the Anhui Key Laboratory of Brain Function and Brain Disease. He also leads the Anhui Clinical Research Center for Neurological Diseases (Neurosurgery) and the Anhui Neurosurgery Quality Control Center. Recognized as a leading academic and technical figure in Anhui, a Jianghuai Famous Doctor, recipient of the State Council Special Allowance, and winner of the Chinese Physician Award. He serves as a member of the 6th Committee of the China Zhi Gong Party in Anhui, the 11th Anhui Provincial CPPCC Committee, and the 13th National People's Congress.
Academic Positions
- Member and Deputy Leader of the Functional Neurosurgery Group, Chinese Medical Association Neurosurgery Branch
- Member and Deputy Director of the Functional Neurosurgery Committee, World Chinese Neurosurgery Society
- Vice Chairman, China Neuromodulation Alliance
- Member, Neurosurgery Branch of the Chinese Medical Doctor Association
- Standing Committee Member, Brain Glioma Committee, Chinese Medical Doctor Association
- Member, Neuromodulation Committee, Chinese Medical Doctor Association
- Member, Neuro-Oncology Committee, Chinese Anti-Cancer Association
- Vice Chairman, Neurosurgery Branch, Anhui Medical Association
- Vice Chairman, Neurosurgery Branch, Anhui Medical Doctor Association
- Chairman, Brain Glioma Committee, Anhui Medical Doctor Association
- Chairman, Neuro-Oncology Committee, Anhui Anti-Cancer Association
Education and Work Experience
- 1980–1985: Anhui Medical University, Bachelor of Medicine
- 1987–1991: Anhui Medical University, Master in Neuroanatomy
- 1991–1996: Worked at the Anatomy Department, Anhui Medical University
- 1996–1999: Ph.D. in Neurosurgery, Shanghai Second Medical University (now Shanghai Jiao Tong University School of Medicine), Renji Hospital
- 1999–2017: Held roles as Associate Chief Physician and Chief Physician at Anhui Provincial Hospital and Anhui Institute of Stereotactic Neurosurgery; served as Deputy Director and Director of the department, and Deputy Director of the Brain Research Institute
- 2017–Present: Head of Neurosurgery at the First Affiliated Hospital of USTC, Deputy Director of the Anhui Institute of Stereotactic Neurosurgery
Academic Achievements and Impact
Focused on basic and clinical research in neurosurgery, particularly in the diagnosis and treatment of neurological tumors (gliomas, acoustic neuromas, meningiomas, pituitary tumors), movement disorders like Parkinson's disease, trigeminal neuralgia, hemifacial spasm, and stereotactic and functional neurosurgery. Pioneered neuromodulation treatments for refractory neurological diseases, including deep brain stimulation for Parkinson's, essential tremor, and dystonia, spinal cord stimulation for vegetative state awakening, and chronic pain management, achieving leading national standards. Supervised over 30 doctoral and master's students. Received one second prize in Anhui Natural Science, two second prizes, and two third prizes in Anhui Science and Technology Awards. Published over 40 SCI papers, led two National Natural Science Foundation projects, one sub-project of the Ministry of Science and Technology's special project, and two central government-guided local science and technology innovation projects.
Ongoing Projects (Limited to Principal Investigator)
- Anhui Clinical Medical Research Center for Neurological Diseases (Neurosurgery), Central Government-Guided Local Science and Technology Project, 1,000,000 CNY, 2019-01 to 2021-12
- USTC New Medicine Project (Key Direction), 800,000 CNY, 2021-01 to 2023-12
- Sub-project of the Ministry of Science and Technology Key R&D Plan, 300,000 CNY, 2018-01 to 2022-12
Main Research Directions (Enrollment Specialties) and Content
Biology
1. Neurobiology
- Molecular mechanisms of glioma pathogenesis
- Glioma stem cells, exosomes, and tumor microenvironment
- Molecular mechanisms of Parkinson’s and other movement disorders
Clinical Medicine
1. Neurosurgery
- Functional mechanisms of non-coding RNA in glioma diagnosis and treatment
- Molecular metabolomics and radiomics of brain gliomas
- Deep brain stimulation for movement disorders
- Stereotactic and functional neurosurgery
Representative Papers (Last Five Years)
1. Mu M, Niu W, Zhang X, Hu S, Niu C*. LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. Oncogene,2020,39(45):6879-6892.
2. Zhang X, Niu W, Mu M, Hu S, Niu C*. Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop. J Exp Clin Cancer Res. 2020 Sep 22;39(1):196.
3. Wu M, Jiang X, Qiu J, Fu X, Niu C*. Gray and white matter abnormalities in primary trigeminal neuralgia with and without neurovascular compression. J Headache Pain. 2020,21(1):136.
4. Yang Y, Qian J, Mei J, Zhong K, Niu C*. In vivo detection of metabolic changes in the striatum of proteasomal inhibition-induced Parkinson's disease in rats using proton MR spectroscopy at 9.4 T. Int J Neurosci, 2020,130(2):153-160.
5. Xie S, Niu W, Xu F, Wang Y, Hu S, Niu C. Differential expression and significance of miRNAs in plasma extracellular vesicles of patients with Parkinson's disease. Int J Neurosci. 2020 Oct 26:1-16.
6. Chen C, Cheng CD, Wu H, Wang ZW, Wang L, Jiang ZR, Wang AL, Hu C, Dong YF, Niu WX, Qi S, Qi ZP, Liu J, Wang WC, Niu CS*, Liu QS. Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway. Acta Pharmacol Sin. 2021 Jan;42(1):108-114.
7. Cheng CD, Dong YF, Niu WX, Niu CS*. HAUSP promoted the growth of glioma cells in vitro and in vivo via stabilizing NANOG. Pathol Res Pract,2020, 216(4):152883.
8. Wu M, Qiu J, Jiang X, Li M, Wang SD, Dong Q, Fu X, Niu C. Diffusion tensor imaging reveals microstructural alteration of the trigeminal nerve root in classical trigeminal neuralgia without neurovascular compression and correlation with outcome after internal neurolysis. Magn Reson Imaging,2020,71:37-44.
9. Niu WX, Zhou CX, Cheng CD, Bao DJ, Dong YF, Li DX, Yang Y, He H, Niu CS. Effects of lentivirus-mediated CYP17A1 gene silencing on the biological activity of glioma. Neurosci Lett. 2019 Jan 23;692:210-215.
10. Yang Y, Wu JJ, Cheng CD, Bao DJ, Dong YF, Li DX, Niu WX, Zhou CX,G-protein-coupled receptor kinase-5 promotes glioblastoma progression by targeting the nuclear factor kappa B pathway. Niu CS.. Am J Transl Res. 2018 Nov 15;10(11):3370-3384.
Contact Information
Email: niuchaoshi@ustc.edu.cn
Phone: 0551-62284149