Professional Titles and Roles
- PhD Supervisor
- Professor
- Chief Physician
- Administrative Director of Orthopedics, The First Affiliated Hospital of USTC
Current Positions
- Member of the Joint Surgery Group, Orthopedics Branch of the Chinese Medical Association
- Member of the Orthopedic Physicians Branch of the Chinese Medical Doctor Association
- Deputy Head of the Hip Joint Group
- Incoming Chairman of the Orthopedics Branch of the Anhui Medical Association
- Member of the Management Committee of the Chinese College of Orthopedic Surgeons (CCOS)
- Deputy Director of the Professional Evaluation Committee
Honors and Awards
- Anhui Provincial Government Allowance
- State Council Special Allowance
- Jianghuai Famous Doctor Title in Anhui Province
- Academic and Technical Leader
- May 1st Labor Medal
Research Achievements
- Twice awarded the Second Prize for Scientific and Technological Progress in Anhui Province for research on steroid-induced femoral head necrosis and clinical treatment of adult hip dysplasia.
Education and Work Experience
- 1980-1985: Bachelor's in Clinical Medicine, Anhui Medical University
- 1985-1988: Resident Physician, Radiology, Anhui Provincial Hospital
- 1988-1991: Master's in Surgery (Orthopedics), Anhui Medical University
- 1991-1999: Attending and Associate Chief Physician, Orthopedics, Anhui Provincial Hospital
- 1999-2002: PhD in Surgery (Orthopedics), Shanghai Second Medical University
- 2002-Present: Chief Physician, Orthopedics, The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Academic Contributions and Impact
- Over 30 years in clinical and basic research on bone and joint diseases and bone defect repair.
- Trained 2 PhD and 30 master's students.
- Pioneered the lateral decubitus direct anterior approach for hip replacement, known as the Shang Approach, and invented femoral proximal osteotomy reconstruction (Shang Osteotomy).
- Contributed to international guidelines on periprosthetic joint infection and Chinese consensus on hip and knee arthroplasty.
- Published 17 SCI papers as first or corresponding author in bone and soft tissue regeneration, with a total impact factor of 44.083 and approximately 223 citations.
Ongoing Projects (Principal Investigator Only)
- Project Name: Mechanism of Sfrp4 Protein in Promoting Bone Repair via Wnt/Notch Signaling Axis
- Source: National Natural Science Foundation General Project
- Funding: 550,000 RMB
- Duration: 2021-01 to 2024-12
Main Research Directions (Recruitment Specialties) and Content
Biology
1. Bone Biology and Metabolism
1. Mechanisms of osteoclast differentiation and function.
2. Mechanisms of chondrocyte aging.
3. Mechanisms of osteoblast differentiation and function.
4. Mechanisms of mesenchymal stem cell osteogenic differentiation and bone repair.
Clinical Medicine
1. Orthopedic Surgery
1. Mechanistic study of circular RNA in the diagnosis and treatment of osteoporosis.
2. Role of WNT and NOTCH pathways in bone defect repair.
3. Mechanistic study of chondrocyte aging in osteoarthritis development.
4. Research on osteoarthritis prevention and treatment based on single-cell sequencing technology.
2. Basic and Clinical Research on Complex Hip Replacement
Representative Papers (Last Five Years)
1. Sun JK, Luo ZL, Wang GX, Wang Y, Wang Y, Olmedo M, Morandi MM, Barton S, Kevil CG, Shu B, Shang XF(*), Dong Y(*). Notch ligand Jagged1 promotes mesenchymal stromal cell-based cartilage repair. Exp Mol Med. 2018;50(9):126.
2. Qiu B, Xu XF, Deng RH, Xia GQ, Shang XF(*), Zhou PH(*). Construction of chitosan/ZnO nanocomposite film by in situ precipitation. Int J Biol Macromol. 2019;122:82-87.
3. Qiu B, Xu XF, Deng RH, Xia GQ, Shang XF(*), Zhou PH(*). Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1β induced inflammation in synoviocytes in vitro. Int J Mol Med. 2018; 26.
4. Chen M, Luo ZL, Wu KR, Zhang XQ, Ling XD, Shang XF(*). Cementless Total Hip Arthroplasty With a High Hip Center for Hartofilakidis Type B Developmental Dysplasia of the Hip: Results of Midterm Follow-Up. J Arthroplasty. 2016;31(5):1027-34.
5. Chen M, Luo ZL, Ji X, Cheng P, Tang GL, Shang XF(*). Direct Anterior Approach for Total Hip Arthroplasty in the Lateral Decubitus Position: Our Experiences and Early Results. J Arthroplasty. 2017;32(1):131-138.
6. Zhu C, Fang SY, Kong R, Wu KR, Xia R, Shang XF(*). The significance of HBD-3 and fluorescent composite carriers in the processof bone formation in rats infected with Staphylococcus aureus. Eur Rev Med Pharmacol Sci. 2017;21(19):4263-4269.
7. Chen M, Shang XF(*). Surgical treatment for young adult hip dysplasia: joint-preserving options. Int Orthop. 2016;40(5):891-900.
8. Luo ZL, Chen M, Hu F, Ni Z, Ji XF, Zhang XQ, Cheng P, Shang XF(*). Cementless total hip arthroplasty with extended sliding trochanteric osteotomy for high congenital hip dislocation: A trochanteric osteotomy for high congenital hip dislocation: A retrospective study. Medicine. 2017;96(14):e6581.
9. Fu D, Shang XF(*), Ni Z, Shi GG. Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis. Exp Ther Med. 2016;12(4):2735-2740.
10. Shang XF(#), Shu B, Wang Y, Luo Z, Wang G, Barton S, Morandi MM, Kevil C, Dong Y. Human Mesenchymal Stromal Cell Sheet Enhances Allograft Repair in a Mouse Model. Sci Rep. 2017;7(1):7982.
11. Shang XF(#), Wang J(#), Luo ZL, Wang Y, Morandi MM, Marymont JV, Hilton MJ, Dong Y. Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. Sci Rep. 2016;6:25594.
12. Zhou HJ, Fang SY, Kong R, Zhang WW, Wu KR, Xia R, Shang XF(*), Zhu C(*). Effect of low frequency ultrasound plus fluorescent composite carrier in the diagnosis and treatment of methicillin-resistant staphylococcus aureus biofilm infection of bone joint implant. Int J Clin Exp Med. 2018; 11(2):799-805.
13. Zhu C, Zhang WW, Fang SY, Kong R, Zou G, Bao NR, Zhao JN(*), Shang XF(*). Antibiotic peptide-modified nanostructured titanium surface for enhancing bactericidal property. J Mater Sci. 2018; 53(8): 5891-5908.
14. Chen M，Luo ZL ，Zhu C，Wu K ，Shan XF(*). A Reliable Femoral Osteotomy in Total Hip Arthroplasty For Hartofilakids Type C Development Dysplasia of the Hip ：Proximal Femoral Reconstruction. J Arthroplasty. 2019;
Contact Information
E-mail: shangxifu@163.com
Phone: 13955101115