Main Research Directions (Admissions Major) and Content
Clinical Medicine
Ophthalmology
Basic and clinical research on visual function protection after retinal detachment.
Basic and clinical research on diabetic retinopathy.
Pathogenesis and clinical treatment strategies for age-related macular degeneration.
Basic and clinical research of uveal diseases ;
Basic and clinical research of optic nerve diseases ;
Basic and clinical studies of hereditary eye diseases.
PhD Supervisor, Chief Physician, Director of the Department of Ophthalmology at the First Affiliated Hospital of USTC. Awards include Distinguished Professor of Leading Talents in Anhui Province, the first ' Young Jianghuai Famous Doctor ' in Anhui Province'、First Prize in the Ophthalmic Surgery Video Competition by the Anhui Medical Association Ophthalmology Branch, Reserve Leader in Discipline, Young Technical Backbone, Model Worker, First Prize in Young Talent, Outstanding PhD, and Excellent Subspecialty Director.
Education and Work Experience
1996–2001: Wannan Medical College, Bachelor’s degree
2005–2008: West China Medical School, Sichuan University, Master’s degree
2010–2013: First People’s Hospital Affiliated to Shanghai Jiao Tong University, PhD
2001–2009: Anhui Provincial Hospital, Physician
2009–2015: Anhui Provincial Hospital, Attending Physician
2015–2020: First Affiliated Hospital of USTC, Associate Chief Physician
2020–Present: First Affiliated Hospital of USTC, Chief Physician
Academic Achievements and Impact
Dr. Dong has been dedicated to teaching and research in ophthalmology for over 20 years, supervising more than 30 doctoral and master’s students. He received the third prize of the Chinese Medical Science and Technology Award. Ranked in the top 2.9% for retinal detachment on Expertscape.
Published over 20 papers in SCI journals such as the American Journal of Pathology, Current Eye Research, Ophthalmic Research, and IJO.
Current Research Projects (Main Responsible Person Only)
Project Title: Basic and Clinical Research on CIRS-7 Regulating the miR-7a-5p/α-Synuclein Pathway Mediated Parthanatos in Retinal Detachment Photoreceptor Cells
Source: National Natural Science Foundation Project
Funding: 540,000 RMB
Duration: 2021-01 to 2024-12
Project Title: The development and evaluation of clinical prediction models for major injury mechanisms and adjuvant therapeutic drugs of retinal detachment based on deep learning ; new Medical Joint Fund of University of Science and Technology ( important direction )
Source: Hospital-level Project
Funding: 1,000,000 RMB
Duration: 2023/01-2025/12
Project Title: Study on the mechanism of NCOA4-mediated iron autophagic abnormalities on retinal detachment photoreceptor cell damage and its regulatory mechanism ;
Source: anhui Provincial Department of Education University Research Program ( Major Projects )
Funding: 200,000 RMB
Duration: 2023/01-2025/12
Project Title: Medical Artificial Intelligence Joint Fund Innovation Project : Development and Evaluation of Intelligent Diagnosis and Treatment Model of Diabetic Macular Edema Based on Multimodal Data Fusion Deep Learning ( MAI2023C003 )
Source: Hospital-level Project
Funding: 400,000 RMB
Duration: 2023/07-2026/06
Representative Papers (Last Five Years)
1. Yue Guo，Ziyang Ye，Can Deng，Lin Wang，Qihong Gu，Kangkang Ji，Xiaomeng li*，Kai Dong*. Effect of preoperative glucocorticoid application on vitreous Parthanatos-related protein expression in patients with Rhegmatogenous retinal detachment associated with choroidal detachment. Current Eye Research. 1–8. DOI:10.1080/02713683.2024.2408755
2. Ziming Xu, Longlong Luan, Pan Li*, Kai Dong*. Extralong Hot-spots Sensor for SERS Sensitive Detection of Phthalate Plasticizers in Biological Tear and Serum Fluids. Analytical and Bioanalytical Chemistry. 2024, 416(19):4301-4313.
3. Jiazhen Jiang , Dali Tong , Ziyang Ye , Can Deng , Lisong Wang*, Kai Dong*. Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix. Medical Hypotheses. 2024 (185) :111312
4. Jing Wang, Li Lu, Gaocheng Zou, Ziyang Ye, Feiyu Jin, Lin Wang, Genjie Ke, Kai Dong*, Liming Tao*. Transcriptomic analysis of retinal gene in experimental retinal detachment rats and exploration of S100A9 and TLR4 in human vitreous. Current Eye Research. 2023;48(12):1170-1178
5. Xueyan Gao#，Lisong Wang#，Xing Lu#，Yuanye Yan, Yue Guo，Jing Wang，Li Lu*，Kai Dong*. The expression of parthanatos markers and miR-7 mimic protects photoreceptors from parthanatos by repressing α-synuclein in retinal detachment. American Journal of Pathology，2023, 193（11）：1833-1844
6. Feiyu Jin, Di Hu*, Kai Dong*. A rare case of the intraocular iron foreign body mistakenly performed on magnetic resonance imaging. Asian Journal of Surgery. 2023;46(8):3166-3167
7. Di Hu#, Feiyu Jin#, Zhouhuan Xi*, Kai Dong*. Autologous proliferative membrane tamponade for the treatment of retinal detachment with recurrent macular hole: a case report. Asian Journal of Surgery., 2023;46(7):2840-2841
8. Nan Huang, Xueyan Gao, Jinping Li, Xing Lu, Huamei Zhu*, Kai Dong*, Expression levels of ROS and Atg proteins in the vitreous in rhegmatogenous retinal detachment. International Journal of Ophthalmology. 2023;16(3):348-353
9. Kai Dong#*, Nan Yang#, Jie Ding, Yuan-Ye Yan, Li Lu, Yi-Sai Wang*. RNA interference targeting NOX4 protects visual function in an experimental model of retinal detachment by alleviating blood-retinal barrier damage. International Journal of Ophthalmology. 2021;14(1):50-56
10. Yuanye Yan, Yisai Wang, Jie Ding, Li Lu, Genjie Ke, Kai Dong*. TRPML1 inhibited photoreceptor apoptosis and protected the retina by activation of autophagy in experimental retinal detachment[J]. Ophthalmic Research. 2021;64(4):587-594
11. Kai Dong#*, Yuanye Yan# , Li Lu , Yisai Wang , Jinping Li , Mei Zhang , Jie Ding*. PJ34 Protects Photoreceptors From Cell Death by Inhibiting PARP-1 Induced Parthanatos After Experimental Retinal Detachment.[J], Current Eye Research, 2021 ;46(1):115-121.
12. Jie Ding #, Nan Yang #, Yuanye Yan, Yisai Wang, Xiuqin Wang, Li Lu *, Kai Dong*. Rapamycin Inhibited Photoreceptor Necroptosis and Protected the Retina by Activation of Autophagy in Experimental Retinal Detachment [J], Current Eye Research, 2019;44(7):739-745
Contact Information
E-mail: dongkai777@ustc.edu.cn
Phone: 0551-62284043