Youth Member of the Chinese Society of Critical Care Medicine, Youth Member of the Chinese Medical Doctor Association Extracorporeal Life Support Professional Committee, Standing Member of the Critical Care Branch and Standards Committee of the Chinese Health Information and Big Data Association, Deputy Director of the Youth Committee of the Critical Care Medicine Professional Committee of the Chinese Research Hospital Association, Executive Member of the Critical Care Ultrasound Group of the Ultrasound Professional Committee of the Chinese Medical Education Association
Education and Work Experience
- September 2001 – June 2006: Huazhong University of Science and Technology, Master’s and PhD
- January 2011 – April 2012: Louisiana State University, USA, Postdoctoral Fellow
- July 2006 – Present: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- July 2019 – Present: Wuhan Jinyintan Hospital
Academic Achievements and Impact
Mainly researches the molecular immune mechanisms of organ damage related to critical illness, investigating the role of DAPK1 in lung injury and exploring the application value of pro-resolution strategies for inflammation. During the fight against COVID-19, he was among the first globally to report the clinical characteristics and prognosis of critically ill COVID-19 patients, elucidated the risk factors for death, and formulated frontline expert consensus on the management of severe COVID-19. His papers have been published in prestigious journals such as Lancet Respir Med, National Science Review, Critical Care, and Anesthesiology. He has received over 10 research projects including the National Natural Science Foundation of China and the Ministry of Science and Technology Key Research and Development Program. He was selected for the Ministry of Education's Changjiang Scholars Program (Young Scholar).
Ongoing Projects
| Project Name | Source | Funding Indicator Number | Total Funding (10,000 RMB) |
| National Natural Science Foundation | 122 | 122 |
Main Research Directions (Recruitment Specialties) and Content
Critical Care Medicine
Representative Papers (Past Five Years)
1. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y, Pan S, Zou X, Yuan S, Shang Y. Clinical Course and Outcomes of Critically Ill Patients With SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study. Lancet Respir Med. 2020;8(5):475-481. (Corresponding Author)
2. Wu D, Shu T, Yang X, Song JX, Zhang M, Yao C, Liu W, Huang M, Yu Y, Yang Q, Zhu T, Xu J, Mu J, Wang YX, Wang H, Tang T, Ren Y, Wu Y, Lin SH, Qiu Y, Zhang DY, Shang Y, Zhou X. Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19. National Science Review. 2020, April 28. https://doi.org/10.1093/nsr/nwaa086 (Corresponding Author)
3. Wang Y, Yang Y, Chen L, Xiong W, Song L, Li B, Zhou T, Pei L, Yuan S, Yao S, Shang Y. Death-associated protein kinase 1 mediates ventilator-induced lung injury in mice by promoting alveolar epithelial cell apoptosis. Anesthesiology. 2020; Accepted. (Corresponding Author)
4. Yu Y, Xu D, Fu S, Zhang J, Yang X, Xu L, Xu J, Wu Y, Huang C, Ouyang Y, Yang L, Fang M, Xiao H, Ma J, Zhu W, Hu S, Hu Q, Ding D, Hu M, Zhu G, Xu W, Guo J, Xu J, Yuan H, Zhang B, Yu Z, Chen D, Yuan S, Shang Y. Patients With COVID-19 in 19 ICUs in Wuhan, China: A Cross-Sectional Study. Crit Care. 2020 May 14;24(1):219. (Corresponding Author)
5. Xu J, Yang X, Yang L, Zou X, Wang Y, Wu Y, Zhou T, Yuan Y, Qi H, Fu S, Liu H, Xia J, Xu Z, Yu Y, Li R, Ouyang Y, Wang R, Ren L, Hu Y, Xu D, Zhao X, Yuan S, Zhang D, Shang Y. Clinical Course and Predictors of 60-day Mortality in 239 Critically ill Patients with COVID-19: A Multicenter Retrospective Study from Wuhan, China. Critical Care. 2020; Accepted. (Corresponding Author)
6. Shang Y, Pan C, Yang X, Zhong M, Shang X, Wu Z, Yu Z, Zhang W, Zhong Q, Zheng X, Sang L, Jiang L, Zhang J, Xiong W, Liu J, Chen D. Management of critically ill patients with COVID-19 in ICU: statement from frontline intensive care experts in Wuhan, China. Annals of Intensive Care. 2020 10:73 (First Author)
7. Zhang J, Xu, D, Xie B, Zhang Y, Huang H, Liu H, Chen H, Sun Y, Shang Y, Hashimoto K, Yuan S. Poor-sleep is associated with slow recovery from lymphopenia and an increased need for ICU care in hospitalized patients with COVID-19: A retrospective cohort study. Brain, Behavior, and Immunity. 2020; 2020 Jun 6:S0889-1591(20)30994-6. (Corresponding Author)
8. Cui SN, Chen L, Yang YY, Wang YX, Li SN, Zhou T, Xiao HR, Qin L, Yang W, Yuan SY, Yao SL, Shang Y. Activation of Death-Associated Protein Kinase 1 Promotes Neutrophil Apoptosis to Accelerate Inflammatory Resolution in Acute Respiratory Distress Syndrome. Lab Invest. 2019;99(8):1143-1156. (Corresponding Author)
9. Pan S, Wu Y, Pei L, Li S, Song L, Xia H, Wang Y, Yu Y, Yang X, Shu H, Zhang J, Yuan S, Shang Y. BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway. Front Cell Neurosci. 2018;12:267. (Corresponding Author)
10. Gong J, Liu H, Wu J, Qi H, Wu ZY, Shu HQ, Li HB, Chen L, Wang YX, Li B, Tang M, Ji YD, Yuan SY, Yao SL, Shang Y. Maresin 1 prevents lipopolysaccharide-induced neutrophil survival and accelerates resolution of acute lung injury. Shock. 2015;44(4):371-80. (Corresponding Author)