Fang NI, M.D., Ph.D.
Principle Investigator
Tel: +86-551-63606329
Email: fangni@ustc.edu.cn
Address: 443 Huangshan Road, USTC Hefei, Anhui 230027 China
Personal Profile:
Dr. Ni received her bachelor degree in Clinical Medicine from Anhui Medical University, China in 2003. She received her Ph.D. degree in Cell Biology from the University of Science and Technology of China (USTC) in 2013. During 2015-2019, Dr. Ni worked as a Postdoctoral fellow at the Laboratory of Hematology, School of Medicine, Emory University, USA. In September 2019, Dr. Ni joined the Division of Life Sciences and Medicine at USTC as a Principle Investigator and started the Laboratory of Hematology&Immunology.
Research Interest:
The laboratory mainly focuses on biomechanics, metabolism and other frontier directions, through multidisciplinary research, to reveal the regulation mechanism of hematopoietic/immune homeostasis and its imbalance. We are particularly interested in the following two major research areas:
1) Hematology: Hematopoiesis and leukemogenesis
2) Immunology: NK cell-based immunotherapy
Selected Publications:
1. Wu M, Yang H, Liu S, Jiang L, Liang T, Wang Y, Zhu M, Song X, Liu H, Shen J, Wang S, Zhu X, Qu CK, Cheng L, Jiang H, Ni F. Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone. Nat Biomedical Engineering. 2024 Dec 23. doi: 10.1038/s41551-024-01316-1.
2. Wang Y, Huang B, Liang T, Jiang L, Wu M, Liu X, Zhu M, Song X, Zhao N, Wei H, Zheng C, Ni F. Venetoclax acts as an immunometabolic modulator to potentiate adoptive NK cell immunotherapy against leukemia. Cell Reports Medicine. 2024 May 21:101580.
3. Guo C, Wu M, Huang B, Zhao R, Jin L, Fu B, Wang P, Wang D, Zheng M, Fang J, Wei H, Qu K, Ni F. Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19. Genome Medicine. 2022 May 3;14(1):46.
4. Ni F, Yu WM, Wang XY, Fay ME, Young KM, Qiu YZ, Lam WA, Sulchek TA, Cheng T, Scadden DT, and Qu CK. Ptpn21 controls hematopoietic stem cell homeostasis and biomechanics. Cell Stem Cell. 2019 Apr 4; 24(4):608-620.e6.
5. Ni F, Yu WM, Li ZG, Graham DK, Jin LT, Kang S, Rossi MR, Li SY, Broxmeyer HE, and Qu CK. Critical role of ASCT2-mediated amino acid metabolism in promoting leukeamia development and progression. Nature Metabolism. 2019 Mar;1(3):390-403
Job Opportunities:
We are seeking highly motivated undergraduates, graduate students, and post-doctoral fellows to join our research team. Applicants with expertise in hematology, immunology, and molecular and cellular biology are particularly welcome. Please contact Dr. NI Fang directly with your CV and a description of your previous research experience.