Main Research Interests
1. Heterogeneity and personalized treatment of hepatobiliary tumors
2. Development of tumor drug targets and clinical translation
3. Decoding the spatiotemporal evolution and immune microenvironment of tumors
Biography
- Ph.D. Supervisor, Professor, Associate Chief Physician
- Selected for the National Youth Talent Program
- Graduated with a Ph.D. in Surgery from Harbin Medical University in 2019
With extensive experience in clinical diagnosis and basic research in general surgery, particularly in the clinical-basic integration and translation of hepatobiliary and pancreatic tumors, I have achieved several original research outcomes. I have published over 20 high-impact SCI papers as the first author or corresponding author in journals like *Journal of Hepatology*, *Nature Communications*, *Gastroenterology*, *Advanced Science*, and *Clinical Cancer Research*. I have led over 10 national and provincial research projects and served as a project leader and key member for the Ministry of Science and Technology's National Key R&D Program. I hold five national invention patents, with one granted, and have co-authored two books. My research has been reviewed in the *Journal of Hepatology* and cited in international journals like *Nature Reviews Clinical Oncology*. I have received honors such as the Excellent Youth Research Project from the Anhui Provincial Department of Education and the National Outstanding Young Scholar in Medical Cell Biology. Currently, I am the Director of the Research Department at the First Affiliated Hospital of the University of Science and Technology of China and Deputy Director of the Anhui Provincial Key Laboratory of Hepatobiliary and Pancreatic Surgery. I also chair the Innovation and Translation Branch of the Anhui Medical Biotechnology Association.
Representative Papers
1. Sun L, Liu Y, Guo X, Cui T, Wu C, Tao J, Cheng C, Chu Q, Ji C, Li X, Guo H, Liang S, Zhou H, Zhou S, Ma K, Zhang N, Wang J, Liu Y, Liu L. Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors. Nat Commun. 2024 Jun 18;15(1):5209. (Corresponding Author)
2. Ma K, Chu J, Liu Y, Sun L, Zhou S, Li X, Ji C, Zhang N, Guo X, Liang S, Cui T, Hu Q, Wang J, Liu Y, Liu L. Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression. Adv Sci (Weinh). 2024 Mar 9:e2400676. (Corresponding Author)
3. Li X, Liang S, Fei M, Ma K, Sun L, Liu Y, Liu L, Wang J. LncRNA CRNDE Drives the Progression of Hepatocellular Carcinoma by inducing the Immunosuppressive Niche. Int J Biol Sci. 2024 Jan 1;20(2):718-732. (Corresponding Author)
4. Liu Y, Xun Z, Ma K, Liang S, Li X, Zhou S, Sun L, Liu Y, Du Y, Guo X, Cui T, Zhou H, Wang J, Yin D, Song R, Zhang S, Cai W, Meng F, Guo H, Zhang B, Yang D, Bao R, Hu Q, Wang J, Ye Y, Liu L. Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy, J Hepatol. 2023 Apr;78(4):770-782.(First Author)
5. Zheng C, Zhang B, Li Y, Liu K, Wei W, Liang S, Guo H, Ma K, Liu Y, Wang J, Liu L. Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression, Adv Sci (Weinh), 2023, e2206798. (Corresponding Author)
6. Liu Y; Sun L; Guo H; Zhou S; Wang C; Ji C; Meng F; Liang S; Zhang B; Yuan Y; Ma K; Li X; Guo X; Cui T; Zhang N; Wang J; Liu Y; Liu L; Targeting SLP2-mediated lipid metabolism reprograming restricts proliferation and metastasis of hepatocellular carcinoma and promotes sensitivity to Lenvatinib, Oncogene, 2023, 42(5): 374-388. (Corresponding Author)
7. Guo H, Liang S, Wang Y, Zhou S, Yin D, Zhang S, Wang J, Wu D, Ma K, Liu Y, Sun L, Ji C, Li X, Zhou H, Yang G, Guo X, Cui T, Li Z, Liu Y, Wang J, Liu L. Cytochrome B5 type A alleviates HCC metastasis via regulating STOML2 related autophagy and promoting sensitivity to ruxolitinib. Cell Death Dis. 2022 Jul 18;13(7):623. (Corresponding Author)
8. Liang S, Guo H, Ma K, Li X, Wu D, Wang Y, Wang W, Zhang S, Cui Y, Liu Y, Sun L, Zhang B, Xin M, Zhang N, Zhou H, Liu Y, Wang J, Liu L. A PLCB1-PI3K-AKT signaling axis activates EMT to promote cholangiocarcinoma progression. Cancer Res. 2021;81(23):5889-5903. (Corresponding Author)
9. Liu Y, Meng F, Wang J, Liu M, Yang G, Song R, Zheng T, Liang Y, Zhang S, Yin D, Wang J, Yang H, Pan S, Sun B, Han J, Sun J, Lan Y, Wang Y, Liu X, Zhu M, Cui Y, Zhang B, Wu D, Liang S, Liu Y, Song X, Lu Z, Yang J, Li M, Liu L. A Novel Oxoglutarate Dehydrogenase-Like Mediated miR-214/TWIST1 Negative Feedback Loop Inhibits Pancreatic Cancer Growth and Metastasis. Clin Cancer Res. 2019 Sep 1;25(17):5407-5421.(First Author)
Recruitment
1. Recruiting postdoctoral researchers and associate researchers with backgrounds in surgery, immunology, cell biology, oncology, or bioinformatics.
2. Welcoming undergraduates interested in our research areas to pursue a Ph.D. or internships.
Contact Information
Email: liuyao66@ustc.edu.cn