Contact Information
Address: No.443 Huangshan Rd, Hefei City, China
Tel: 0551-63603495
E-mail: cwangust@ustc.edu.cn
Education and Research Experience
Sep, 2009 – Jun, 2014
Hong Kong University of Science and Technology, HK
PhD in Biochemistry, Division of Life Science
Sep, 2005 – Jun, 2009
Shanghai Jiao Tong University, Shanghai
Bachelor of Engineering in Bioengineering, School of Life Sciences and Biotechnology
Research Interests
Neuronal Structural Chemical Biology
1) Biochemical and structural biology of neuronal signaling protein complex organization and regulation;
2) Scaffolding proteins regulating neuronal cell polarity and the balance of neuro circuits
3) Molecular mechanisms of common psychiatric disorders and potential therapeutic drug discovery
Selected Publications
1. Kong C, Qu X, Liu M, Xu W, Chen D, Zhang Y, Zhang S, Zhu F, Liu Z, Li J, Huang C*, and Wang C*. Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance. Nat Commun. 2023, 14(1): 6860.
2. Shi Y#, Lin L#, Wang C*, and Zhu J*.Promotion of row 1–specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia. Sci Adv. 2022, 8, eabn4556.
3. He L, Jiang W, Li J*, and Wang C*. Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment. J Biol Chem. 2022, 298(9):102272.
4. Zhang X#, Li N#, Zhang J#, Zhang Y#, Yang X#, Luo Y, Zhang B, Xu Z, Zhu Z, Yang X, Yan Y, Lin B, Wang S, Chen D, Ye C, Ding Y, Lou M, Wu Q, Hou Z, Zhang K, Liang Z, Wei A, Wang B, Wang C, Jiang N, Zhang W, Xiao G, Ma C, Ren Y, Qi X, Han W, Wang C*, and Rao F*. 5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab.2021, 3(10):1400-1414.
5. Ye J#, Zou G#, Zhu R, Kong C, Miao C, Zhang M, Li J*, Xiong W*, and Wang C*. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nat Commun.2021, 12(1):297.
6. Zhang M#, Lin L#, Wang C*, and Zhu J*. Double inhibition and activation mechanisms of Ephexin family RhoGEFs. PNAS. 2021, 118(8):e2024465118.
7. Ye J#, Li J#, Ye F, Zhang Y, Zhang M, and Wang C*. Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance. PNAS.2020, 117(2):1207-1215.
8. Li J#, Zhu R#, Chen K, Zheng H, Zhao H, Yuan C, Zhang H*, Wang C*, and Zhang M*. Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins. Nat Chem Biol. 2018, 14(8):778–787.
9. Qu X, Zhao S, Wan C, Zhu L, Ji T, Rossi P, Wang J, Kalodimos, C.G., Wang C, Xu W*, and Huang C*. Structural basis for the dynamic chaperoning of disordered clients by Hsp90. Nature Structural & Molecular Biology. 2024, https://doi.org/10.1038/s41594-024-01337-z.