Contact Information
Address: 443 Huangshan Road, Hefei, Anhui 230027, P. R. China
Email: xuetian@ustc.edu.cn.
Lab Webpage: http://www.xuelab.ustc.edu.cn
Research Field of Interests
Phototransduction, Non-image Vision, Sensory Neural Circuit, Stem Cell, Gene Editing, Photoreceptor Regeneration
Dr. Xue has long been engaged in the research of understanding physiological characteristics and signaling mechanisms of light perception, revealing neural circuits involved in this process and exploring methods for vision restoration after photoreceptor degeneration. He has published 70 papers and citations over 7500 times, and his h-index is 40.
Dr. Xue revealed the photo-transduction mechanism of mammalian intrinsically photosensitive retinal ganglion cells (ipRGCs, a novel type of photoreceptors discovered two decades ago), which is crucial for understanding the kinetodynamic features of light responses in non-image-forming vision (Nature 2011). He also conducts in-depth study on neuronal mechnisms underlying various light-regulated physiological functions, such as the induction of negative mood by nighttime light (Nat. Neurosci., 2020), the promotion of cortical synaptic development by early-life light exposure (Cell, 2022), and the regulation of glucose metabolism by light (Cell, 2023). In another groundbreaking work, he achieved mammalian near-infrared vision using photoreceptor-binding up-conversion nanomaterials, reaching beyond the limits naturally set for visual perception in mammals (Cell 2019).
For translational research in ophthalmology, he developed a crispr-case9-based in vivo HDR gene editing tool, which enabled genetic repair in post-mitotic cells and rescued photoreceptor degeneration in a mouse model with an inherited visual disease （Science Advances 2019）. By comparing the molecular traits of human retinae and human-origin retinal organoids, he discovered unique transcriptional factors in human retinal development（Science Advances 2020）. He also optimized the differentiation conditions for stem-cell derived retinal organoids, and established a quality control system to monitor the physiological function of retinal organoids differentiated in vitro（Stem Cell Research 2019；Stem Cells 2021）. He built up a single-cell transcriptome atlas of the aging human and macaque retina, which is valuable to understanding of the molecular characteristics of primate retina, as well as molecular regulation of aging progression and related diseases(Dev. Cell, 2020). Heidentified macular specific subtypes of cone photoreceptors and Müller glial cells (Natl. Sci. Rev., 2021) and discovered that Müller glial cells can modulate the light response of cone photoreceptors through the thyroid hormone pathway (Protein Cell, 2023)；Moreover, he created the first nonhuman primate model for retinitis pigmentosa (RP) using adeno-associated virus (AAV)-delivered CRISPR/SaCas9 technology. This primate model is of critical importance to study the pathogenesis of RP and to evaluate potential therapeutic options in the future（Science Bulletin 2021).
Education and Positions
09/2012–present: Professor, School of Life Sciences, Division of Life Sciences and Medicine, USTC
06/2011-08/2012: Research Associate, Johns Hopkins University School of Medicine
03/2006-05/2011: Postdoctoral Fellow (with Dr. King-Wai YAU) Johns Hopkins University School of Medicine, Neuroscience
09/2000-05/2005: Ph.D., Johns Hopkins University School of Medicine, Cellular & Molecular Physiology
09/1995-06/2000: B.S., USTC, Biophysics and Neuroscience; Special Class for Gifted Young (SCGY)
Honors & Awards
2024 China Youth May Fourth Medal
2024 CNS-CST Outstanding Neuroscientist Award
2024 Top 10 Scientific Advances of China in 2023
2023 Important Medical Progress of China in 2023
2023 New Cornerstone Investigator Program
2022 XPLORER PRIZE
2022 Significant Research Advances in Neuroscience in China
2022 First Natural Science Award of Anhui Province
2021 13th Tan Jiazhen Life Science Innovation Award
2021 Zhang Xiangtong Neuroscience Young Scientist Award
2020 Significant Research Advances in Neuroscience in China
2019 Cell Best of 2019, Cell press (9 Best Articles published in Cell in 2019)
2019 China’s Top 10 Research Advances in Life Sciences in 2019
2019 National Science Fund for Distinguished Young Scholars
2014 Human Frontier Science Program (HFSP) Young Investigator Award
2013 National Science Fund for Excellent Young Scholars
2012 Overseas High-level Talent Introduction Plan
2007 Final list of Life Science Research Foundation Fellowships
2006 Best Paper Award, Circulation, American Heart Association (1 out of 1129)
2004 NIH Stem Cells Scholarship at the Keystone Stem Cells Symposium, NIH
2003 American Heart Association 2003 Scientific Sessions, Selected Late-Breaking Science
2001 Scholarship of Cellular and Molecular Physiology (CMP), Johns Hopkins Medical School
Publications
Representative publications
(# equal contributions, *co-corresponding authors，†lead contact)
1. Meng JJ#, Shen JW#, Guang L, Ouyang CJ, Hu JX, Li ZS, Zhao H, Shi YM, Zhang M, Liu R, Chen JT, Ma YQ, Zhao H and Xue T *† (2023). Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis. Cell. 2023, 186 (2), 398-412.
2. Hu JX#, Shi YM#, Zhang JM, Huang XF, Wang Q, Zhao H, Shen JW, Chen ZP, Song W, Zheng P, Zhan SL, Sun YP, Cai PF, An K, Ouyang CJ, Zhao BZ, Zhou QX, Xu L, Xiong W, Zhang Z, Meng JJ, Chen JT, Ma YQ, Zhao H, Zhang M, Qu K, Hu J, Luo MH, Xu FQ, Chen XW, Xiong Y, Bao J*, and Xue T*† (2022). Melanopsin retinal ganglion cells mediate light-promoted brain development. Cell. 185, 3124-3137.e15
3. Ma Y#, Bao J#*, Zhang Y#, Li Z, Zhou Z, Zhou X, Wan C, Huang L, Zhao Y, Han G*, Xue T*† (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell 177, 243-255 e215. Cell Best of 2019, Cell press (9 Best Articles which published in Cell in 2019)
4. Wei M#, Sun YP#, Li SZ#, Chen YN, Li LF, Fang MH, Shi RH, Tong DL, Chen JT, Ma YQ*, Qu K*, Zhang M*, Xue T*† (2023). Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling. Protein & Cell. 14(8) :603-617
5. Yi WY#, Lu YF#, Zhong SJ#, Zhang M#*, Sun L, Dong H, Wang MD, Wei M, Xie HH, Qu HQ, Peng RM, Hong J, Yao ZQ,Tong YY,Wang W, Ma Q, Liu ZY, Ma YQ, Li SZ, Yin CH, Liu JW, Ma C, Wang XQ*,Wu Q*, and Xue T*† (2021). A single-cell transcriptome atlas of the aging human and macaque retina, National Science Review 8, nwaa179, https://doi.org/10.1093/nsr/nwaa179
6. An K#, Zhao H#*, Miao Y, Xu Q, Li YF, Ma YQ, Shi YM, Shen JW. Meng JJ, Yao YG, Zhang Z, Chen JT, Bao J, Zhang M and Xue T*† (2020). A Circadian Rhythm-gated Subcortical Visual Circuit for Nighttime Light Induced Depressive-like Behaviors, Nature Neuroscience 23, 869-880.
7. Xie H#, Zhang W#, Zhang M#*, Akhtar T, Li Y, Yi W, Sun X, Zuo Z, Wei M, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K*, Xue T*† (2020). Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC derived retinal organoids. Science Advances 6, eaay5247.
8. Cai Y#, Cheng T#, Yao Y#, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M*, Qiu Z*, Xue T*† (2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Science Advances 5, eaav3335.
9. Xue T*, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW* (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature 479, 67-73. (Faculty of 1000: f1000.com/13360986).
Other publications
10. Rao F*, Xue T* (2024). Circadian-independent light regulation of mammalian metabolism. Nature Metabolism 6, 1000–1007. （Review）
11. Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J*, Liu Q* (2024). Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization. Cell Metabolism 36(5):1059-1075.e9.
12. Xu H#, Wang S#, Fang M, Luo S, Chen C, Wan S, Wang R, Tang M, Xue T, Li B*, Lin J*, Qu K* (2023). SPACEL: deep learning-based characterization of spatial transcriptome architectures. Nature Communications 14(1):7603.
13. Wang HW, Wang S*, Zhou JY, Deng HX, Sun SS, Xue T, Ma YQ*, Gong XL* (2023). Bio-Inspired Semi-Active Safeguarding Design with Enhanced Impact Resistance via Shape Memory Effect. Advanced Functional Materials 33, 2212093.
14. Xiang N#, Li YJ#, Liu MY, Wu QQ, Zhang YX, Jin HZ, Wang Q, Li YW, Tong DL, Xue T, Jin TC*, Bao W, Chen Z* (2023). Antibody responses following the surge of SARS-CoV-2 Omicron infection among patients with systemic autoimmune rheumatic diseases. Rheumatology Advances in Practice 7(2):rkad064.
15. Ghanam AR, Ke SW, Wang SJ, Elgendy R, Xie CY, Wang SQ, Zhang R, Wei M, Liu WG, Cao J, Zhang Y, Zhang Z, Xue T, Zheng Y, Song XY(2023). Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress.iScience 26(1):105740.
16. Zhou P, Shen JW, Liang J, Xue T, Sun YS, Zhang LH*, Tian CL* (2023). Metabolic state oscillations in cerebral nuclei detected using two-photon fluorescence lifetime imaging microscopy,Chinese Chemical Letters Volume 34, Issue 1.
17. Tong DL#, Zhang M#, Yang YR#, Xia H#, Tong HY, Zhang HJ, Zeng WH, Liu MZY, Wu Y, Ma H, Hu X, Liu WY, Cai Y, Yao YF, Yao YC, Liu KP, Shan SF, Li YJ, Gao G, Guo WW, Peng Y, Chen SH, Rao JH, Zhao JX, Min J, Zhu QJ, Zheng YM, Liu LX, Shan C, Zhong K, Qiu ZL*, Jin TC*, Chiu S*, Yuan ZM*, Xue T*† (2023). Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques. Protein & Cell. 14(1):69-73
18. Khan MH#, Huang X#, Tian X, Ouyang C, Wang D, Feng S, Chen J, Xue T*, Bao J*, and Zhang X* (2022). Short- and long-term effects of 3.5-23.0 Tesla ultra-high magnetic fields on mice behaviour. European Radiology 10.1007/s00330-022-08677-8.
19. Li B, Zhang W, Guo C, Xu H, Li L, Fang M, Hu Y, Zhang X, Yao X, Tang M, Liu K, Zhao X, Lin J, Cheng L, Chen F, Xue T, Qu K*(2022). Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution. Nature Methods 19(6):662-670.
20. Tang HD, Dong WY, Hu R, Huang JY, Huang ZH, Xiong W, Xue T, Liu J*, Yu JM*, Zhu X*, Zhang Z* (2022). A neural circuit for the suppression of feeding under persistent pain. Nature Metabolism https://doi.org/10.1038/s42255-022-00688-5
21. Ren J, Xue T, Wang L.(2022). Shining more light on G protein signalling modules: a novel optogenetic tool for Gq activation. Science China Life Science, doi: 10.1007/s11427-022-2150-1. Online ahead of print
22. Zou G, Xia J, Luo HY, Xiao D, Jin J, Miao CJ, Zuo X, Gao QQ, Zhang Z, Xue T, You YZ, Zhang Y, Zhang L, Xiong W* (2022). Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells. Nature Metabolism 4, 1138–1149.
23. Li L, Zhao H*, Xie H, Akhtar T, Yao Y, Cai Y, Dong K, Gu Y, Bao J, Chen J, Zhang M, Zhong K, Xu W*, Xue T*† (2021). Electrophysiological characterization of photoreceptor-like cells in human inducible pluripotent stem cell-derived retinal organoids during in vitro maturation. Stem Cells 39，959-974.
24. Li SZ#, Hu YZ#, Li YQ#, Hu M, Wang WC, Ma YQ, Cai Y, Wei M, Yao YC, Wang Y, Dong K, Gu YH, Zhao H, Bao J, Qiu ZL, Zhang M*, Hu XT*, Xue T*† (2021). Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina. Science Bulletin 66, 374-385.
25. Cheng P#, Tian X#, Tang W, Cheng J, Bao J, Wang H, Zheng S, Wang Y, Wei X, Chen T, Feng H, Xue T, Goda K, and He H. (2021). Direct control of store-operated calcium channels by ultrafast laser. Cell Research 7, 758-772.
26. Huang X#, Huang P#, Huang L#, Hu Z, Liu X, Shen J, Xi Y, Yang Y, Fu Y, Tao Q, Lin S, Xu A, Xu F, Xue T, So KF*, Li H*, and Ren C*† (2021). A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment. Neuron 109, 347-362 e347.
27. Li X#, Zhang J#*, Li D, He C, He K, Xue T, Wan L, Zhang C, and Liu Q*†. (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron 109, 957-970 e8.
28. Zhang J, Gao F, Ma Y, Xue T, Shen Y*(2021). Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease. iScience. 24(11):103327.
29. Wang Y, Zeng W, Lin B, Yao Y, Li C, Hu W, Wu H, Huang J, Zhang M, Xue T, Ren D, Qu L, Cang C*(2021). CLN7 is an organellar chloride channel regulating lysosomal function. Science Advances 7(51):eabj9608.
30. Zhu X, Tang HD, Dong WY, Kang F, Liu A, Mao Y, Xie W, Zhang X, Cao P, Zhou W, Wang H, Farzinpour Z, Tao W, Song X, Zhang Y, Xue T, Jin Y, Li J, Zhang Z*.(2021) Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states.Nature Neuroscience 24(4):542-553.
31. Guo W, Fan S, Xiao D, Dong H, Xu G, Wan Z, Ma Y, Wang Z, Xue T, Zhou Y, Li Y, Xiong W*. (2021). A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes. Nature Communications 12(1):6403.
32. Liu Q#, Su LY#*, Sun C, Jiao L, Miao Y, Xu M, Luo R, Zuo X, Zhou R, Zheng P, Xiong W, Xue T, and Yao YG*† (2020). Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. Redox Biology 34, 101560.
33. Lu Y#, Shiau F#, Yi W#, Lu S, Wu Q, Pearson J, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O’Brien G, Sherman T, Duan X, Fertig D, Goff L, Zack J, Handa J, Xue T*, Bremner R*, Blackshaw S*,Wang X* and Clark B*† (2020). Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development. Developmental Cell. 53, 473-491.
34. Akhtar T, Xie H, Khan MI, Zhang M*, Xue T*† (2019). Accelerated photoreceptor differentiation of hiPSC-derived retinal organoids by contact co-culture with retinal pigment epithelium, Stem Cell Research, 39, 101491.
35. Yu N, Huang L, Zhou Y*, Xue T*, Chen Z*, and Han G* (2019). Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics. Advanced Healthcare Materials, e1801132. (Review)
36. Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y, Tao Q, Xiao J, Yuan T, An K, Zhao H, Pu M, Xu F, Xue T, Luo M, So KF, Ren C*† (2019). A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy. Neuron 102, 128-142 e128.
37. Zhu H#, Wang N#, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G*, Xiong W*† (2018). Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell173, 1716-1727 e1717.
38. Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M (2018). An unexpected INAD PDZ tandem-mediated PLCbeta binding in Drosophila photo receptors. Elife 7.doi:10.7554/eLife.41848
39. Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B*, Lin W* (2018). Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer biology & therapy 20, 52-64.
40. Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin, Z. B* (2018). Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports 10,1267-1281.
41. Tang J, Qin N, Chong Y, Diao Y, Yiliguma, Wang Z, Xue T, Jiang M, Zhang J*, Zheng G* (2018). Nanowire arrays restore vision in blind mice. Nature Communications 9, 786.
42. Cheng J, Huang X, Liang Y, Xue T, Wang L*, Bao J* (2018). Plasticity of Light-induced Concurrent Glutamatergic and GABAergic Quantal Events in the Suprachiasmatic Nucleus. Journal of Biology Rhythms 33, 65-75.
43. Huang DF, Wang MY, Yin W, Ma YQ, Wang H, Xue T, Ren DL*, and Hu B*†. (2018). Zebrafish Lacking Circadian Gene per2 Exhibit Visual Function Deficiency. Frontiers in Behavioral Neuroscience 12, 53.
44. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X(2017). A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. Journal of Clinical Investigation 127, 2631-2646.
45. Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW (2017). Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Current Biology 27, 1791-1800.
46. Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu C, Xiao P, Liu CY, Thomsen ARB, Joseph Cahill T, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP (2017). Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nature Communications 8, 14335.
47. Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C (2015). Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chemical Communications (Camb) 51, 8153-6.
48. Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP (2014). Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. Journal of Biology Chemistry 289, 24215-2
49. Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014). Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs. Nature Communications5, 4047.
50. Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. PNAS 110, 4045-50.
51. Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR (2012). Restoration of vision after transplantation of photoreceptors. Nature485, 99-103.
52. Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature457, 281-7. (Faculty of 1000: f1000.com/1144855).
53. Luo DG, Xue T, Yau KW (2008) How vision begins: An odyssey. PNAS 105, 9855-62 (Review)
54. Fu YB#, Kefalov V#, Luo DG#, Xue T#, Yau KW (2008). Quantal noise from human red cone pigment. Nature Neuroscience 11, 565-71
55. Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA (2007). Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation115, 1839-1850.
56. El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Molecular Endocrinology21, 753-764.
57. Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006). A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model. Circulation114, 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.
58. Ardehali H, Xue T, Dong P, Machamer C (2005). Targeting of the mitochondrial membrane proteins to the cell surface for functional studies. Biochemical and Biophysical Research Communications 338, 1143-51.
59. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005). Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circulation Research 97, 159-67.
60. Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. Reproductive Toxicology 20, 377-91.
61. Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005). Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers. Cardiovascular Research 67, 263-73.
62. Wang G#, Xue T#, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF (2005). Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells 23, 1526-34.
63. Xue T#, Cho H#, Akar F#, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005). Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers. Circulation 11, 111-20. Issue highlights, Best Paper Award, Circulation 2005
64. Xue T, Sato K, Kodama K, Ennis I, French RJ, Li RA (2003). Novel interactions identified between µ-conotoxin and the Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry. Biophysical Journal85, 2299-310.
65. Azene EM#, Xue T#, Li RA (2003). Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels. Journal of Physiology547, 349-356.
66. Henrikson CA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003). Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating. Journal of Biology Chemistry 278, 13647-54.
67. Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E (2003). Molecular basis of isoform-specific µ-conotoxin block of cardiac, skeletal muscle and brain Na channels. Journal of Biology Chemistry 278, 8717-24.
68. Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification. Journal of Biology Chemistry277, 46233-42.
69. Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization. Circulation Research90, 1267-1273.
70. Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Letters511, 159-164.