Main Research Interests
- Mechanisms of ion transmembrane transport
- Structure and function of disease-related transport proteins
- Structure-based drug research and development
Position
Special Professor, Ph.D. Supervisor
- Studied at Peking University and the Beijing Institute of Life Sciences, earning a Ph.D. (2008-2014)
- Conducted postdoctoral research at UT Southwestern Medical Center (2014-2019)
- Joined the University of Science and Technology of China in 2019
Research focuses on the structure and regulatory mechanisms of ion channels and transport proteins. Methods include cryo-electron microscopy, antibody screening, and in vitro functional reconstruction. Published in journals like Nature and eLife.
Recruitment
The lab welcomes undergraduates for Ph.D. studies or internships and continuously seeks outstanding postdoctoral researchers from diverse backgrounds.
Publications
1. She, J., Zeng, W., Guo, J., Chen, Q., Bai, X.C., Jiang, Y. (2019). Structural mechanisms of phospholipid activation of the human TPC2 channel. eLife 8, e45222.
2. Wang, Y., Nguyen, N.X., She, J., Zeng, W., Yang, Y., Bai, X.C., Jiang, Y. (2019). Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter. Cell 177, 1252-1261.
3. Chen, Q., Zeng, W., She, J., Bai, X.C., Jiang, Y. (2019). Structural and functional characterization of an otopetrin family proton channel. eLife 8, e46710.
4. She, J., Guo, J., Chen, Q., Zeng, W., Jiang, Y., Bai, X.C. (2018). Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130-134.
5. Guo, J., She, J., Zeng, W., Chen, Q., Bai, X.C., Jiang, Y. (2017). Structures of the calcium-activated, non-selective cation channel TRPM4. Nature 552, 205-209. (equal contribution)
6. Chen, Q., She, J., Zeng, W., Guo, J., Xu, H., Bai, X.C., Jiang, Y. (2017). Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550, 415-418. (equal contribution)
7. Lee, C., Guo, J., Zeng, W., Kim, S., She, J., Cang, C., Ren, D., Jiang, Y. (2017). The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature 547, 472-475.
8. Liu, T., Liu, Z., Song, C., Hu, Y., Han, Z., She, J., Fan, F., Wang, J., Jin, C., Chang, J., Zhou, J., Chai, J. (2012). Chitin-induced dimerization activates a plant immune receptor. Science 336, 1160-1164.
9. She, J., Han, Z., Kim, T.W., Wang, J., Cheng, W., Chang, J., Shi, S., Wang, J., Yang, M., Wang, Z.Y., Chai, J. (2011). Structural insight into brassinosteroid perception by BRI1. Nature 474, 472-476.
Contact
Email: jishe@ustc.edu.cn