Contact Information
Address: School of Life Sciences, University of Science and Technology of China, 230026 Hefei, P. R. China
Tel: 86-551-63607451
Fax: 86-551-63607451
E-mail: hyliu@ustc.edu.cn
Education and Research Experience
2001.01-present Professor, School of Life Sciences, USTC
1985.09-1990.06 B.S, Department of Biology, USTC
1990.09-1996.01 Ph.D., University of Science and Technology of China
1993.11-1995.11 Visiting phD student in Laboratory of Physical Chemistry, ETH-Zurich
1996.01-1998.12 Lecturer, School of Life Sciences, USTC
1998.12-2000.12 Research Associate, Department of Chemistry, Duke University, with Professor Weitao Yang
1999.12-2000.12 Research Associate, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, with Professor Jan Hermans
2000.12-2001.01 Visiting scholar, Laboratory of Physical Chemistry, ETH-Zurich
2001.08-2001.10 Visiting professor, Department of Chemistry, Duke University
2005.03-2005.08 Visiting professor, Laboratory of Physical Chemistry, ETH-Zurich
Research Interests
1. Methods and applications of computer simulation of biomolecular systems.
2. Methods and applications of protein design.
Representative Publications
1. Yufeng Liu, Sheng Wang, Jixin Dong, Linghui Chen, Xinyu Wang, Lei Wang, Fudong Li, Chenchen Wang, Jiahai Zhang, Yuzhu Wang, Si Wei, Quan Chen*, Haiyan Liu*，De novo protein design with a denoising diffusion network independent of pre-trained structure prediction models； Nature Methods, 2024, DOI: 10.1038/s41592-024-02437-w.
2. Xu, Yang; Hu, Xiuhon; Wang, Chenchen; Liu, Yongrui Liu; Chen, Quan*; Liu, Haiyan*; De novo Design of Cavity-containing Proteins with a Backbone-centred Neural Network Energy Function, Structure, 2024, 32(4), 424-432. DOI:10.1016/j.str.2024.01.006
3. Hu, Xiuhong; Xu, Yang; Wang, Chenchen; Liu, Yufeng Liu; Zhang, Lu; Zhang, Jiahai; Wang, Wenning*; Chen, Quan*; Liu, Haiyan*; Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain; Proc Natl Acad Sci USA, 2023;120:2305603120.
4. Liu, Yufeng; Zhang, Lu; Wang, Weilun; Zhu, Min; Wang, Chenchen; Li, Fudong;, Zhang, Jiahai; Li, Houqiang; Chen, Quan*; Liu, Haiyan*; Rotamer-free protein sequence design based on deep learning and self-consistency, Nature Computational Science, 2022,2, 451–462.
5. Huang, Bin; Xu. Yang; Hu,Xiuhon; Liu, Yongrui; Liao, Shanhui; Zhang, Jiahai; Huang, Chengdong; Hong, Jingjun; Chen, Quan*; Liu, Haiyan*; A backbone-centred energy function of neural networks for protein design; Nature, 2022, 602(7897):523-528.