Research Interests
1. Studying the structure and function of important membrane proteins involved in lipid metabolism, regulation, and transport using structural biology, biochemistry, and biophysics.
2. Investigating the structure and function of membrane contact sites using structural biology and cell biology.
Education and Research Experience
- 2009.09-2013.06: Bachelor’s degree from the School of Life Science and Technology, Huazhong University of Science and Technology
- 2013.09-2018.01: Ph.D. in Science from the School of Life Sciences, Tsinghua University
- 2018.04-2021.04: Postdoctoral Researcher, Department of Molecular Biology, Princeton University
- 2021.05-Present: Professor and Ph.D. Advisor, School of Life Sciences and Medicine, USTC
Funding
2021 Anhui Province Overseas Innovation Talent Plan
2022 National Overseas High-Level Talents Youth Project
2022 National Natural Science Foundation of China General Program
Publications (*Co-first author, # Co-corresponding author)
1. He J*, Liu G*, Kong F*, Tan Q, Wang Z, Yang M, He Y, Jia X, Yan C, Wang C, Qian H. Structural basis for the transport and substrate selection of human urate transporter 1. Cell Rep. 2024 Aug 27;43(8):114628.
2. Gong M, Peng C, Yang C, Wang Z, Qian H, Hu X, Zhou P, Shan C, Ding Q. Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection. PLoS Pathog. 2024 Aug 22;20(8): e1012444.
3. Wang Z, Yang M, Yang Y, He Y, Qian H. Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1. Nat Commun. 2023 May 3;14(1):2529.
4. Wu X, Yan R, Cao P, Qian H#, Yan N#. Structural advances in sterol-sensing domain-containing proteins. Trends Biochem Sci. 2022 Apr;47(4):289-300.
5. Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N. Structural basis for sterol sensing by Scap and Insig. Cell Rep. 2021 Jun 29;35(13):109299.
6. Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021 Mar 5;371(6533):eabb2224.
7. Qian H*, Wu X*, Du X*, Yao X, Zhao X, Lee J, Yang H, Yan N. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020 Jul 9;182(1):98-111.e18.
8. Qian H*#, Zhao X*, Yan R*, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N#. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338.
9. Wang L*, Qian H*, Nian Y*, Han Y*, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 May;581(7808):329-332.
10. Qian H*, Cao P*, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019 May 24;10(1):2320.
11. Gong X, Qian H. Purification and Characterization of Human Niemann-Pick C1 Protein. Methods Mol Biol. 2019;1949:257-267.
12. Yan R*, Qian H*#, Lukmantara I, Gao M, Du X, Yan N#, Yang H#. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018 Oct 22;47(2):248-256.e4.
13. Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 Aug 10;361(6402):eaas8935.
14. Qian H*, Zhao X, Cao P, Lei J, Yan N, Gong X*. Structure of the Human Lipid Exporter ABCA1. Cell. 2017 Jun 15;169(7):1228-1239.e10.
15. Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu JJ, Li W, Wang HW, Espenshade P, Yan N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 2016 Nov;26(11):1197-1211.
16. Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q, Yan N. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. 2016 Jun 2;165(6):1467-1478.
17. Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N. Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Res. 2015 Apr;25(4):401-11.
Recruitment
The lab is recruiting postdoctoral researchers and special associate researchers with backgrounds in structural biology, lipid metabolism, and cell biology, offering competitive compensation. Undergraduate students interested in these research areas are also welcome.
Email: hongwuqian@ustc.edu.cn
Office: Room 307, YiSuan Building, School of Life Sciences, West Campus, USTC