Contact Information
Tel: 86-551-63607464
Fax:86-551-63601443
E-mail: yyshi@ustc.edu.cn
Homepage:http://bionmr.ustc.edu.cn/
Researcherid: http://www.researcherid.com/rid/B-3240-2009
Education and Research Experience
1960-1965, Biophysics, Department of Physics, University of Science and Technology of China (USTC)
1965-1970, Assistant researcher, Chinese traditional medicine institute，Beijing
1970- Assistant professor, Lecturer, Associate professor, Professor USTC,
1979-1981, Visiting scholar, Department of Chemistry of Roma University and CNRS Lab. of Structural Chemistry, Italy;
1985 & 1990, Visiting Scholar, Department of Chemistry, University of Groningen, Netherlands.
1997, Member of the Chinese Academy of Sciences (CAS)
2003, Fellow of TWAS (the academy of sciences for the developing world)
Research Interests
Our laboratory is interested in structural biological basis and molecular cellular mechanism of aging and degenerative diseases. We focus on epigenetic regulation of aging, especially the epigenetic regulation of the mitochondrial genome, and the structural basis, molecular and cellular mechanisms of the degenerative diseases, especially neurodegenerative diseases. We use structural biology methods, as well as other biophysical, biochemical, molecular, and cellular biology methods. We also interested in molecular mechanism and functional implication in cell of membraneless organelles, biomacromolecular aggregates, phase separation, phase transition. We have been published in the international important academic journals more than 180 papers, cited more than 5000 times.
Representative Publications
(*: corresponding author)
1. MQ Lv, WW Zhou, YJ Hao, FD Li, HF Zhang H, XB Yao, YY Shi*, L Zhang*. Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15，Cell Discovery. 2024 Jan 30;10(1):11
2. ZY Xu, YR Liu Y, FD Li, Y Yang, H Zhang, X Liu, X Xie, XJ Chen, YY Shi*, L Zhang*.Phase separation of hnRNPA1 and TERRA regulates telomeric stability. J Mol Cell Biol. 2024 Sep 23:mjae037.
3. X.D. Liu, S.Q. Shen, P.Z. Wu. F.D. Li, X. Liu, C. Y. Wang, Q.G. Gong, J.H. Wu, X.B. Yao, H. F Zhang,* and Y. Y. Shi*, Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function, Nucleic Acids Research, 2019, 1–18.
4. P.Z. Wu, X. Liu, G.G. Gong, Y.Y.Shi, J.H. Wu. Application of NMR Spectroscopy to Determine Small RNA Structure. Methods Mol. Biol. 2020;2113: 341-353.
5. G.D. Xie, TV. Vo, G. Thillainadesan, S. Holla, B. Zhang, Y. Jiang, M.Q. Lv, Z. Xu, C.Y. Wang, V. Balachandran, Y.Y. Shi Y, F.D Li*, S. Grewal*. A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing. Nat. Communication. 2019,16;10(1):251
6. J.J. Chen, Z. Wang, X. Guo, F.D. Li, Q.T. Wei, X. Chen, D.S. Gong , Y. Xu, W. Chen, Y. Liu, J. H. Kang*, Y.Y. Shi*, TRIM66 Reads Unmodified H3R2K4 and H3K56ac to Respond to DNA Damage in Embryonic Stem Cells. Nat. Communication. 2019,10(1):4273.
7. Y. Liu, L.Xu, C.Xie, J. Hong, FD Li, K. Ruan K, JJ. Chen, JH Wu*, YY Shi*. Structural Insights Into ceNAP1 Chaperoning Activity Toward ceH2A-H2B, Structure. 2019, 27(12):1798-1810.e3.