Professor and Ph.D. Supervisor. Studied in the Department of Biology at the University of Science and Technology of China (USTC) from 1987 to 2000, earning bachelor's, master's, and doctoral degrees. From January 1999 to February 2000, he was a joint Ph.D. student at the IGM Institute, Université Paris-Sud, France. From 2000 to the end of 2003, he conducted postdoctoral research at the French National Centre for Scientific Research and the Structural Genomics Laboratory at Université Paris-Sud. In 2004, he was appointed as a professor and Ph.D. supervisor at the School of Life Sciences, USTC, and as a researcher at the Hefei National Laboratory for Physical Sciences at the Microscale. He served as the Associate Dean of the School of Life Sciences from 2009 to 2014, Director of Academic Affairs from 2014 to 2019, Assistant to the President and Provost of USTC since 2019, and Vice President since December 2021.
He has published over 100 research papers in journals such as Nature sub-journals, PNAS, EMBO Reports, NAR, JBC, and Structure. He received the Anhui Provincial Natural Science Second Prize in 1998 and the Sino-French Science and Technology Exchange Association Biotechnology Award in 2000. He served as an executive director of the Chinese Society of Biochemistry and Molecular Biology from 2005 to 2016, Chairman of the Anhui Society of Biochemistry and Molecular Biology since 2014, Chinese representative to the FAOBMB since 2015, a guideline expert and member of the expert group for the Ministry of Science and Technology's major research program Protein Machines and Life Process Regulation since 2016, a guideline expert for Biomacromolecules and Microbiomes since 2020, and a member of the IUBMB Nomenclature Committee for Non-Enzyme Proteins since 2021.
Main Papers (#first author, corresponding author, out of ~120 papers)
1) Xia LY#, Jiang YL#, Kong WW#, Sun H, Li WF, Chen Y, Zhou CZ. Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. 2020; Nature Plants. 6:708-717.
2) Jin H#, Jiang YL#, Yang F, Zhang JT, Li WF, Zhou K, Ju J, Chen Y, Zhou CZ. Capsid structure of a freshwater cyanophage Siphoviridae Mic1. 2019; Structure. 27(10):1508-1516.
3) Yang HB#, Hou WT#, Cheng MT#, Jiang YL, Chen Y, Zhou CZ. Structure of a MacAB-like efflux pump from Streptococcus pneumoniae. Nature Comm. 2018; 9(1):196.
4) Jiang YL#, Wang XP#, Sun H#, Han SJ, Li WF, Cui N, Li GM, Zhang JY, Cheng W, Cao DD, Zhang ZY, Zhang CC, Chen Y, Zhou CZ. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc Natl Acad Sci USA. 2018; 115(2):403-408.
5) Jiang YL#, Jin H#, Yang HB, Zhao RL, Wang SL, Chen Y, Zhou CZ. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. J Biol Chem. 2017; 292(15):6213-6224.
6) Xie J, Cai K, Hu HX, Jiang YL, Yang F, Hu PF, Cao DD, Li WF, Chen Y, Zhou CZ. Structural analysis of the catalytic mechanism and substrate specificity of Anabaena alkaline invertase InvA reveals a novel glucosidase. J Biol Chem. 2016; 291(49):25667-77.
7) Yu LY#, Cheng W#, Zhou K#, Li WF, Yu HM, Gao X, Shen X, Wu Q, Chen Y, Zhou CZ. Structures of an all-α protein running along the DNA major groove. Nucl Acids Res. 2016; 44(8):3936-45.
8) Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW, Chen Y, Zhou CZ. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports. 2016; 17(2): 235-48.
9) Shi WW#, Jiang YL#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H, Chen Y, Zhou CZ. Structure of a novel O-GlcNAc transferase GtfA reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem. 2014; 289(30):20898-20907.
10) Yang YH#, Jiang YL#, Zhang J, Wang L, Bai XH, Zhang SJ, Ren YM, Li N, Zhang YH, Zhang Z, Gong Q, MEi Y, Xue T, Zhang JR, Chen Y, Zhou CZ. Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLoS Pathogens. 2014; 10(6): e1004169.
11) Dai YN, Chi CB, Zhou K, Cheng W, Jiang YL, Ren YM, Ruan K, Chen Y, Zhou CZ. Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase. J Biol Chem. 2013; 288(32):22985-92.
12) Zhang CC, Zhou CZ. ATPase as a switch in P(II) signal transduction. Proc Natl Acad Sci USA. 2013;110(32):12863-4.
13) Guo PC, Ma JD, Jiang YL, Wang SJ, Bao ZZ, Yu XJ, Chen Y, Zhou CZ. Structure of yeast sulfhydryl oxidase Erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space. J Biol Chem. 2012; 287(42):34961-9.
14) Lian FM, Yu J, Ma XX, Yu XJ, Chen Y and Zhou CZ. Biochemical and structural insights into the catalytic cycle of the yeast peroxiredoxin Ahp1. J Biol Chem. 2012; 287(21):17077-87.
15) He YX#, Zhang NN#, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y and Zhou CZ. N-terminal domain of Bombyx mori fibroin mediates assembly of the silk in response to the pH decrease. J Mol Biol. 2012; 418(3-4):197-207.
16) Jiang YL#, Zhang JW#, Yu WL, Cheng W, Zhang CC, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ and Chen Y. Structural and enzymatic characterization of a Streptococcal ATP/diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH. J Biol Chem. 2011; 286(41):35906-14.
17) Ma XX, Guo PC, Shi WW, Luo M, Tan XF, Chen Y and Zhou CZ. Structural plasticity of the thioredoxin recognition site of yeast methionine-S-sulfoxide reductase Mxr1. J Biol Chem. 2011, 286(15):13430-7.
18) Zhao MX#, Jiang YL#, Xu BY, Chen Y, Zhang CC and Zhou CZ. Crystal structure of cyanobacterial signal transduction protein PII in complex with PipX. J Mol Biol. 2010; 402:552-559.
19) Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC and Zhou CZ. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci USA. 2010; 107(28) 12487-92.
20) Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, and Zhou CZ. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010; 398(4):614-22.
21) He YX#, Huang L#, Xue Y#, Fei X, Teng YB, Rubin-Pitel S, Zhao H and Zhou CZ. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010; 285(7):4603-11.
22) Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Reports. 2009; 10(12):1320-6.
Contact Information:
School of Life Sciences, West Campus, USTC, Rooms 507-509, Office: 522
Phone: 0551-63600406 (office); 63600407 (lab)
Email: zcz@ustc.edu.cn
Homepage: [http://czlab.ustc.edu.cn/](http://czlab.ustc.edu.cn/)