Professor, Ph.D. advisor, recipient of the National Outstanding Youth Fund and Anhui Provincial Outstanding Youth Fund, Chief Scientist of the CAS Pioneer Project. Principal Investigator at the Key Laboratory of Immune Response and Immunotherapy, School of Life Sciences and Medicine, University of Science and Technology of China (USTC). Earned a Ph.D. from USTC in 2015, focusing on NK cells and the immune microenvironment. Published related findings as (co-)corresponding author in journals such as Nat Immunol, Clin Cancer Res, J Hematol Oncol, and Cell Mol Immunol. Leads projects funded by the National Natural Science Foundation and major provincial projects. Awarded the Young Scholar Award by the Chinese Society of Immunology.
Main Research Interests
1. NK cells and the tumor immune microenvironment;
2. Identifying immune intervention targets for tumors and autoimmune inflammation;
3. Developing new molecules for immunotherapy using synthetic biology concepts.
Representative Research Papers
[1] Xiaohu Zheng#*, Zhuanghao Hou#, Yeben Qian, Yongwei Zhang, Quanwei Cui, Xuben Wang, Yiqing Shen, Zhenbang Liu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian*,Guangming Huang* and Haiming Wei*. Tumors evade immune cytotoxicity by altering the surface topology of NK cells. Nature Immunology. 2023 Mar 23.
[2]Dong Wang #, Xiaohui Li #, Defeng Jiao, Ying Cai, Liting Qian, Yiqing Shen, Yichen Lu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Xiaohu Zheng*, Haiming Wei*. J Hematol Oncol. 2023 Mar 27.
[3] Sanyou Chen#, Wanhe Li#, Xiaohu Zheng#, Pei Yu, Pengfei Wang, Ziting Sun, Yao Xu, Defeng Jiao, Xiangyu Ye, Mingcheng Cai, Mengze Shen, Mengqi Wang, Qi Zhang, Fei Kong, Ya Wang, Jie He, Haiming Wei, Fazhan Shi*, and Jiangfeng Du*, Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond. Proc Natl Acad Sci USA. 2022 Feb 1;119(5):e2118876119.
[4] Xiaohu Zheng*, Yaqi Wu, Jiacheng Bi, Yingying Huang, Ying Cheng, Yangyang Li, Yuwei Wu, Guoshuai Cao, Zhigang Tian*, The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy. 2021 Dec 12. Cell Mol Immunol. 2022 Feb;19(2):192-209
[5] Zhigang Nian, Xiaohu Zheng*, Yingchao Dou, Xianghui Du, Li Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei*, Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells, Clinic Cancer Research, 2021 Nov 1;27(21):6026-6038
[6] Jiacheng Bi, Chaoyue Zheng and Xiaohu Zheng*. Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells. Cell Mol Immunol. 2021, DOI: 10.1038/s41423-020-00632-1.
[7] Yonggang Zhou#; Binqing Fu#; Xiaohu Zheng#; Dongsheng Wang; Changcheng Zhao; Yingjie qi; Rui Sun; Zhigang Tian; Xiaoling Xu*; Haiming Wei*. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. National Science Review. 2020, DOI:10.1093/nsr/nwaa041.
[8] Xiaohu Zheng, Yeben Qian, Binqing Fu, Defeng Jiao, Yong Jiang, Peng Chen, Yiqing Shen, Huafeng Zhang, Rui Sun, Zhigang Tian* and Haiming Wei *, Mitochondrial fragmentation limits natural killer cell-based tumour immunosurveillance. Nature Immunology, 2019 Dec, 20;1656-1667.
[9] Yong Jiang#, Xiaohu Zheng#, Defeng Jiao, Peng Chen, Yechuan Xu, Haiming Wei*, Yeben Qian*. Peptidase inhibitor 15 as a novel blood diagnostic marker for cholangiocarcinoma. EBioMedicine, 2019 Feb;40:422-431.
[10] Xiaohu Zheng , Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z*, Wei H*, EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance. Cancer Research, JAN 15 2017, 77; 482-493.
[11] Xiaohu Zheng, Min Cheng, Binqing Fu, Xiaolei Fan, Qing Wang, Xiaoqing Yu, Rui Sun, Zhigang Tian*, Haiming Wei*.Targeting LunX inhibits non-small-cell lung cancer growth and metastasis. Cancer Research, March 15, 2015 75; 1080-90.
[12] Xiaohu Zheng, Zhigang Tian, Haiming Wei*. Lung specific X protein as a novel therapeutic target for lung cancer. OncoImmunology, 2015 Aug 17;4(12):e1052931.
Recruitment
1. Hiring postdoctoral researchers or associate researchers with backgrounds in immunology, cell biology, etc.
2. Welcoming students interested in tumors and immunology for graduate studies.
Contact
E-mail: ustczxh@ustc.edu.cn