Contact Information
Phone: +86-551-63600720
E-mail: jint@ustc.edu.cn
Lab Website: Tjlab.ustc.edu.cn
Mailing Address: Biomedical Science Building, Rm 304, Mid-campus, USTC, Hefei, Anhui 230027 China
Personal Profile
Dr. Jin graduated from the University of Science and Technology of China (USTC) in 2003 with a Bachelor’s Degree in Biology and received his Ph.D. degree in Molecular Biochemistry and Biophysics (MBB) from the Illinois Institute of Technology (IIT) in 2008. In 2008, he received the Sigma Xi Award from the Illinois Institute of Technology for Outstanding Accomplishments in Research and Scholarship.During 2008-2014, Dr. Jin did his Postdoctoral training with Dr. Tsan Xiaoat the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). In the beginning of 2015, Dr. Jin joined the School of Life Sciences at the University of Science and Technology of China as a Tenure-Track Investigator and started the Structural Immunology Laboratory. He was promoted as a full professor in 2020.
Research Interests
The long-term research goal of the Laboratory of Structural Immunology is to use molecular, biochemical, and immunological methodologies to expand the understanding of infectious as well as autoimmune diseases, and to improve the quality of life for patients. We are particularly interested in the following four major research areas:
1) Immune Mechanism of Infection and Intervention Strategy
2) Tumor Immunology and immunotherapy
3) Protein engineering and drug discovery
Research Key Words
SARS-CoV-2, COVID-19, Antibody, Nanobody, X-ray crystallography, Allergy, Host microbe interaction, T-cell epitope, Inflammasome, Virology, Antibody treatment, Check point inhibitor, Vaccine, Diagnostic kits，Tumor immunology
Selected Publications (#First author, *Corresponding author):
1. Hu J#, Zhu LP#, Wang RQ, Zhu L, Chen F, Hou Y, Ni K, Deng S, Liu S, Ying W, Sun JL, Li H*, Jin T* (2024). Identification, Characterization, Cloning, and Cross-Reactivity of Zan b 2, a Novel Pepper Allergen of 11S Legumin. J Agric Food Chem. 72(14):8189-8199. doi: 10.1021/acs.jafc.4c00351.
2. Li H#, Zhu L#, Wang RQ, Zhu L, Hu J, Chen F, Ma L, Tang R, Liu S, Ni K, Ye X, Zhang Y, Sun JL, Jin T* (2024). A new pepper allergen Zan b 1.01 of 2S albumins: Identification, cloning, characterization, and cross-reactivity. Asian Pac J Allergy Immunol. doi: 10.12932/AP-300423-1595.
3. Liu M, Yang Z, Wu Q, Yang Y, Zhao D, Cheng Q, Li Y, Liu G, Zhao C, Pan J, Zhang Y, Deng F*, Jin T* (2023). IL-4-secreting CD40L+ MAIT cells support antibody production in the peripheral blood of Heonch-Schönlein purpura patients. Inflamm Res. doi: 10.1007/s00011-023-01816-x.
4. Zhang C, Li Y, Samad A, He H, Ma H, Chen Y, Jin T* (2023). Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors. Int J Biol Macromol. 254(3):127856. doi: 10.1016/j.ijbiomac.2023.127856.
5. Kombe AJK, Zoa-Assoumou S, Bounda GA, Nsole-Biteghe FA, Jin T*, Zouré AA (2023). Advances in Etiopathological Role and Control of HPV in Cervical Cancer Oncogenesis. Front Biosci (Landmark Ed). 28(10):245. doi: 10.31083/j.fbl2810245.
6. Zeng W, Jia X, Chi X, Zhang X, Li E, Wu Y, Liu Y, Han J, Ni K, Ye X, Hu X, Ma H, Yu C, Chiu S, Jin T* (2023). An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1&2 and most variants. Int J Biol Macromol. 253(3):126817. doi: 10.1016/j.ijbiomac.2023.126817.
7. Xiang N#, Li YJ#, Liu MY, Wu QQ, Zhang YX, Jin HZ, Wang Q, Li YW, Tong DL, Xue T, Jin T*, Bao W, Chen Z* (2023). Antibody responses following the surge of SARS-CoV-2 Omicron infection among patients with systemic autoimmune rheumatic diseases. Rheumatol Adv Pract. 7(2):rkad064. doi: 10.1093/rap/rkad064.
8. Chen YL#, Xie XX#, Zheng P#, Zhu C, Ma H, Khalid Z, Xie YJ, Dang YZ, Ye Y, Sheng N, Zhong N, Lei WH, Zhang C, Zhang LJ, Jin T*, Cao MJ* (2023). Selection, identification and crystal structure of shark-derived single-domain antibodies against a green fluorescent protein. Int J Biol Macromol.247:125852. doi: 10.1016/j.ijbiomac.2023.125852.
9. Li Y#, Zhang C, Samad A, Zheng P, Li Y, Chen F, Jin T* (2023). Structural mechanism of dsDNA recognition by the hMNDA HIN domain: New insights into the DNA-binding model of a PYHIN protein. Int J Biol Macromol. 245:125461. doi: 10.1016/j.ijbiomac.2023.125461.
For complete list of publications, please see Dr. Tengchuan Jin’s PubMed link and Google Scholar page.
We welcome students with backgrounds in Physics, Chemistry, Computer Science, Biology or Medicine join our group. We do not discriminate race, sex, age, and believe.