Main Research Directions
1. Protein engineering and labeling techniques
2. Visualization and functional analysis of biomacromolecules
3. Fluorescent sensing and quantitative visualization of life metabolites
4. Point-of-care testing (PoCT) for drugs and metabolites in blood and medical translation
Specially Appointed Professor, PhD Supervisor
- Completed PhD at the Institute of Chemistry, CAS, in 2010
- Conducted postdoctoral research at EPFL, Switzerland, and Max Planck Institute for Medical Research, Germany (2013-2021) under Prof. Kai Johnsson
Joined USTC's School of Life Sciences and Medicine in June 2021, focusing on interdisciplinary research in chemistry, life sciences, and medicine. Utilizes chemical biology to address biomedical challenges: developing novel protein labeling techniques for biomolecule tracking; creating protein-based biosensors to visualize and analyze core metabolite regulation in processes like gene expression and signal transduction; exploring efficient PoCT methods for medical diagnostics of blood metabolites/drugs.
Published over 30 SCI papers, with 16 as first or corresponding author in journals like Nat. Chem. Biol, Angew. Chem. Int. Ed, J. Am. Chem. Soc, and Org. Lett, with over 2000 citations. Research featured by NCCR Chemical Biology, Biophotonics World, ScienceDaily, and Phys.org.
[Lab Website](http://faculty.ustc.edu.cn/xuelin)
Recruitment
Hiring associate researchers, assistant researchers, and accepting postdocs, graduate, and undergraduate interns. Welcoming talented individuals passionate about our research areas. Requirements: love for research, motivation, strong independent work skills, and teamwork spirit. Background in chemical biology, biochemistry, organic chemistry, molecular biology, or cell biology preferred.
Address: Life Sciences Building 254, West Campus, USTC
Email: linxue@ustc.edu.cn
Representative Publications (* indicates corresponding author):
1. Lin Xue*, Pa ul Schnacke, Michelle S. Frei, Birgit Koch, Julien Hiblot, Richard Wombacher, Sebastian Fabritz, Kai Johnsson*. Probing coenzyme A homeostasis with semisynthetic biosensors. Nat Chem Biol., 2023, 19, 346–355.
2. Lin Xue, Qiuliyang Yu, Rudolf Griss, Alberto Schena, Kai Johnsson*. Bioluminescent Antibodies for Point-of-Care Diagnostics. Angew. Chem. Int. Ed.2017, 56, 7112−7116.
3. Lin Xue, Efthymia Prifti, and Kai Johnsson*. A General Strategy for the Semisynthesis of Ratiometric Fluorescent Sensor Proteins with Increased Dynamic Range. J. Am. Chem. Soc.2016, 138, 5258−5261.
4. Lin Xue, Iuliia A Karpenko, Julien Hiblot, Kai Johnsson*. Imaging and manipulating proteins in live cells through covalent labeling. Nat. Chem. Biol.2015, 11, 917–923.
5. Qiuliyang Yu, Lin Xue, Julien Hiblot, Rudolf Griss, Sebastian Fabritz, Clothilde Roux, Pierre-Alain Binz, Dorothea Haas, Jürgen G. Okun, Kai Johnsson*. Semisynthetic sensor proteins enable metabolic assays at the point of care. Science. 2018, 361, 1122–1126.
6. Guoping Li, Dongjian Zhu, Qing Liu, Lin Xue*, Hua Jiang*. A Strategy for Highly Selective Detecting and Imaging Hypochlorite Using Selenoxide Elimination. Org. Lett. 2013,15, 2002−2005.
7. Guoping Li, Dongjian Zhu, Qing Liu, Lin Xue*, Hua Jiang*. Rapid Detection of Hydrogen Peroxide Based on Aggregation Induced Ratiometric Fluorescence Change. Org. Lett. 2013,15, 924−927.
8. Guoping Li, Dongjian Zhu, Lin Xue*, Hua Jiang*. Quinoline-based fluorescent probe for ratiometric detection of lysosomal pH. Org. Lett. 2013, 15, 5020–5023.
9. Dongjian Zhu, Guoping Li, Lin Xue*, Hua Jiang*. Development of ratiometric near-infrared fluorescent probes using analyte-specific cleavage of carbamate. Org. Biomol. Chem. 2013, 11, 4577−4580.
10. Qing Liu, Guoping Li, Dongjian Zhu, Lin Xue*, Hua Jiang*. Design of quinoline-based fluorescent probe for the ratiometric detection of cadmium in aqueous media. Chin. Chem. Lett.2013,24, 479−482.
11. Lin Xue, Qing Liu, Hua Jiang*. Ratiometric Zn2+ Fluorescent Sensor and New Approach for Sensing Cd2+ by Ratiometric Displacement. Org. Lett. 2009, 11, 3454−3457.
12. Lin Xue, Guoping Li, Dongjian Zhu, Qing Liu, Hua Jiang*. Rational Design of a Ratiometric and Targetable Fluorescent Probe for Imaging Lysosomal Zinc Ions. Inorg. Chem. 2012,51, 10842−10849.
13. Lin Xue, Guoping Li, Cailan Yu, Hua Jiang*. A Ratiometric and Targetable Fluorescent Sensor for Quantification of Mitochondrial Zinc Ions. Chem.- Eur. J. 2012, 18, 1050−1054.
14. Lin Xue, Guoping Li, Qing Liu, Huanhuan Wang, Chun Liu, Xunlei Ding, Shenggui He*, Hua Jiang*. Ratiometric Fluorescent Sensor Based on Inhibition of Resonance for Detection of Cadmium in Aqueous Solution and Living Cells. Inorg. Chem. 2011, 50, 3680−3690.
15. Lin Xue, Zhangjian Fang, Guoping Li, Huanhuan Wang, Hua Jiang*. Ratiometric Fluorescent Sensor for Detecting Zinc Ions in Aqueous Solution and Living Cells with Two-photon Microscopy. Sens. Actuators. B Chem.2011, 156, 410−415.
16. Lin Xue, Chun Liu, Hua Jiang*. Highly Sensitive and Selective Fluorescent Sensor for Distinguishing Cadmium from Zinc Ions in Aqueous Media. Org. Lett. 2009, 11, 1655−1658.
17. Lin Xue, Chun Liu, Hua Jiang*. A Ratiometric Fluorescent Sensor with a Large Stokes Shift for Imaging Zinc Ions in Living Cells. Chem. Commun. 2009, 1061−1063.
18. Lin Xue, Huanhuan Wang, Xiaojun Wang, Hua Jiang*. Modulating Affinities of Di-2-picolylamine (DPA)-Substituted Quinoline Sensors for Zinc Ions by Varying Pendant Ligands. Inorg. Chem. 2008, 47, 4310−4318.