Principal Investigator
The First Affiliated Hospital, Division of Life Sciences and Medicine
University of Science & Technology of China
e-mail: wangxt11@ustc.edu.cn
homepage: https://wangxt-lab.ustc.edu.cn/main.htm
Personal Profile
Dr. Xiangting Wang received her Ph.D. in Molecular Pathology from the University of California, San Diego in 2007, where she stayed for her postdoctoral research. Her research interests include long non-coding RNA, RNA modification and the related binding protein/modification enzymes in diseases. She is one of the first researchers worldwide involved in the long non-coding RNAs studies, and has publications on Nature, PLoS Biology, Genome Research, and Cell Discovery. Dr. Wang is the associate editor of RNA Biology, and has served as reviewer for Nature Reviews MCB, Nature Methods and PNAS.
Research Interests
(1) Long noncoding RNAs and RNA binding proteins
(2) The regulatory mechanisms and biological implications of RNA modification-mediated cellular processing
Selected Publications（#co-author, *corresponding author and co-corresponding author）
1. Xiaolin Liang#, Meng Gong#, Zhikai Wang#, Jie Wang#, Weiwei Guo#, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong*, Chuanhai Fu*, Xiangting Wang*. LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination. Cell Discovery. 2024; 10, 54.
2. Yan Jin, Bowen Zhang, Junxia Lu, Yingdong Song, Wei Wang, Wei Zhang, Fanghong Shao, Meng Gong, Meiting Wang, Xiaolin Liang, Shuqin Li, Zhi Zhang, Ge Shan, Xiangting Wang*. Long non-coding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3. PLoS Biology. 2021; 19 (6): e3001297.
3. Tao Shen#, Wangxiao Xia#, Sainan Min#, Zixuan Yang#, Lehua Cheng#, Wei Wang, Qianxi Zhan, Fanghong Shao, Xuehan Zhang, Zhiyu Wang, Yan Zhang, Guodong Shen, Huafeng Zhang, Liling Wu, Guangyan Yu, Qingpeng Kong*, Xiangting Wang*. A pair of long intergenic non-coding RNA LINC00887 variants act antagonistically to control Carbonic Anhydrase IX transcription upon hypoxia in tongue squamous carcinoma progression. BMC Biology. 2021; 19 (1), 192.
4. Fei Wang#, Dalong Ren#, Xiaolin Liang#, Shengwei Ke, Bowen Zhang, Bing Hu*, Xiaoyuan Song*, Xiangting Wang*. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019; 47(12): 6315-6329.
5. Siling Liu#, Zhengbo Wang#, Dong Chen#, Bowen Zhang#, Renrong Tian#, Jing Wu, Ying Zhang, Kaiyu Xu, Liumeng Yang, Chao Cheng, Jian Ma, Longbao Lv, Yongtang Zheng, Xintian Hu, Yi Zhang*, Xiangting Wang*, Jiali Li*. Annotation and cluster analysis of spatiotemporal and sex-related lncRNA expression in Rhesus macaque brain. Genome Research. 2017; 27:1608-1620.
6. Xiangting Wang#, Xiaoyuan Song#, Christopher K. Glass, Michael G. Rosenfeld. The long arm of long noncoding RNAs: Roles as sensors regulating gene transcriptional programs. RNA Worlds: From Life's Origins to Diversity in Gene Regulation; Also published in Cold Spring Harb Perspect Biol. 2011; 3 (1): a003756.
7. Xiangting Wang, Shigeki Arai, Xiaoyuan Song, Donna Reichart, Kun Du, Gabriel Pascual, Paul Tempst, Michael G. Rosenfeld*, Christopher K. Glass*, Riki Kurokawa*. Induced ncRNAs allosterically modify RNA-binding Proteins in cis to inhibit transcription. Nature. 2008; 454 (7200):126-130.