Education and Work Experience
- 2000-2005: Bachelor of Medicine, Clinical Medicine, Wannan Medical College
- 2005-2008: Master of Science, Physiology, Wannan Medical College
- 2008-2011: Ph.D. in Neurobiology, Fudan University
- 2012-2019: Lecturer, Department of Physiology and Neurobiology, Wannan Medical College
- 2015-2018: Postdoctoral Researcher, Department of Neurobiology, Harvard University
- 2019-present: Special Researcher, First Affiliated Hospital, University of Science and Technology of China
Academic Achievements and Impact
Mainly engaged in the research of neural circuits related to chronic pain, emotional disorders, and their interactions. Published several papers in academic journals such as Neuron, Nature Communications, and Cell Reports, with a total citation frequency of over 1,000 times. Some work has been rated as Exceptional by Faculty 1000.
Ongoing Projects (Principal Investigator Only)
1. Project: Study on Gate Control Theory of Spinal Pain Mediated by C-Fibers
- Source: National Natural Science Foundation of China (32070999)
- Funding: 580,000 RMB
- Duration: 2021-01 to 2024-12
2. Project: Study on Spinal Circuits for Reflexive Defensive Behaviors and Emotional Responses to Pain
- Source: National Natural Science Foundation of China (32070999)
- Funding: 540,000 RMB
- Duration: 2023-01 to 2026-12
Main Research Areas (Recruitment Fields) and Content
Biology
1. Neurobiology
- Neural circuit mechanisms of chronic pain
- Exploration of the Pathogenic Mechanisms of Depression with Different Etiologies
- Neural Mechanisms of Sensation-Emotion Interaction
Representative Papers (Last Five Years)
1. Wang XY#, Jia WB#, Xu X, Chen R, Wang LB, Su XJ, Xu PF, Liu XQ, Wen J, Song XY, Liu YY, Zhang Z*, Liu XF*, Zhang Y*. A glutamatergic DRN-VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice. Nature communications, 2023, 14(1): 5124.
2. Wang XY#, Xu X#, Chen R#, Jia WB, Xu PF, Liu XQ, Zhang Y*, Liu XF*, Zhang Y*. The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain. Cell reports, 2023, 42(10): 113170.
3. Wang LB#, Su XJ#, Yan JJ, Wu QF, Xu X, Wang XY, Liu XQ, Song XY, Zhang Z, Hu W*, Liu XF*, Zhang Y*. Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia. iScience, 2023, 26(5): 106764.
4. Zhang Y, Liu SB, Zhang YQ, Goulding M, Wang YQ*, Ma QF*, Timing mechanisms underlying gate control by feedforward inhibition, Neuron, 2018, 99(5):941-955.（F1000评价为“Exceptional”）
5. Chen R, Xu X, Wang XY, Jia WB, Zhao DS, Liu N, Pang Z, Liu XQ, Zhang, Y*. The lateral habenula nucleus regulates pruritic sensation and emotion. Molecular brain, 2023, 16, 54.
6. Wang LB#, Su XJ#, Wu QF, Xu X, Wang XY, Chen M, Ye JR, Maimaitiabula A, Liu XQ, Sun W*, Zhang Y*. Parallel Spinal Pathways for Transmitting Reflexive and Affective Dimensions of Nocifensive Behaviors Evoked by Selective Activation of the Mas-Related G Protein-Coupled Receptor D-Positive and Transient Receptor Potential Vanilloid 1-Positive Subsets of Nociceptors. Front. Cell. Neurosci., 2022, 16:910670.
Contact Information
E-mail: yzhang19@ustc.edu.cn
Phone: 0551-62284454