Ph.D. Supervisor, second class professor, currently serving as the Deputy Director of the Institute of Geriatric Diseases at the First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital)，director of the Engineering Research Centre of Elderly Health Products in Anhui Province. He is a Professor, Chief Pharmacist, and holds several key positions including President of the Anhui Evidence-Based Medicine Society, Member of the Clinical Drug Trials Professional Committee of the Chinese Pharmacological Society, Council Member of the Chinese Society of Biotechnology, and Standing Committee Member of the Pharmacogenomics Professional Committee of the Chinese Pharmacological Society. He is also an editorial board member of several journals including *Chinese Journal of New Drugs*, *Biology*, *Chinese Journal of Geriatrics*, *China Pharmaceuticals*, and *Chinese Journal of Clinical Healthcare*. In 2020, he was received special allowance from Anhui Provincial Government. In 2009, he was selected as one of the first batch of academic and technical leaders in Anhui Province and is a member of the Anhui Provincial 115 Innovation Team.
Education and Work Experience
- 1985.9–1989.6: Bachelor’s in Pharmacy, West China University of Medical Sciences
- 1998.9–2001.6: Master’s in Clinical Pharmacology, Anhui Medical University
- 2009.9–2011.6: Ph.D. in Chemistry and Material Science, University of Science and Technology of China
- 1989.6–1996.08: Pharmacist, Anhui Provincial Hospital, Anhui Medical University
- 1996.09–2001.08: Senior Pharmacist, Anhui Provincial Hospital, Anhui Medical University
- 2001.09–2007.08: Associate Chief Pharmacist, Anhui Provincial Hospital, Anhui Medical University
- 2007.09–2017.11: Chief Pharmacist, Anhui Provincial Hospital, Anhui Medical University
- 2017.12–Present: Chief Pharmacist, First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Academic Achievements and Impact
Dr. Xu has dedicated many years to research in pharmacy, nano-drug formulations, pharmacology, and anti-inflammatory immunology. He has supervised over 60 Ph.D. and master's students. He has received seven Anhui Provincial Science and Technology Progress Awards and was the first contributor to win the Second Prize of the Anhui Provincial Natural Science Award in 2020.
He has published dozens of papers in SCI-indexed journals such as *Adv. Funct. Mater.*, *J. Mater. Chem.*, *Adv. Opt. Mater.*, *Talanta*, *ACS Appl. Poly. Mater.*, *ACS Appl. Nano Mater.*, *Analyst*, *Nutrients*, and *Anal. Bioanal. Chem.*.
Ongoing Projects (Principal Investigator Only)
1. Project Name: Construction of MOFs-Enhanced Sandwich SERS Active Substrate for Dynamic Monitoring of Colorectal Cancer Biomarker NDK
- Source: National Natural Science Foundation of China
- Total Funding: 590,000 + 590,000 RMB
- Duration: 2021-01 to 2024-12
2. Project Name: Anhui Academic and Technical Leaders Fund
- Total Funding: 50,000 + 50,000 RMB
3. Project Name: Research on the development of series of products with the same source of food and medicine
- Source: Anhui Guoke Inspection Technology Co. (Horizontal Project)
- Total Funding: 300,000 RMB
- Duration: 2021-01 to 2024-12
Primary Research Areas (Graduate Programs) and Content
Biology
1. Biophysics
- Toxicology research on plasticizers
- Detection of trace plasticizers in food
- Detection of tumor biomarkers
Research Content
- Synthesis of a series of high-performance nanomaterials as substrates for surface-enhanced Raman spectroscopy (SERS) for the highly sensitive detection of trace contaminants in food and tumor-related biomarkers.
- Extensive research in pharmacology, including the establishment of cell and animal models and the study of related signal transduction pathways.
Representative Papers (Last Five Years)
1. Zhang, X.; Gan, T.; Xu, Z.; Zhang, H.; Wang, D.; Zhao, X.; Huang, Y.; Liu, Q.; Fu, B.; Dai, Z.; Li, P. and Xu, W.*, Immune-like sandwich multiple hotspots SERS biosensor for ultrasensitive detection of NDKA biomarker in serum. Talanta, 2024, 271, 125630. (Corresponding Author)
2. Zhang, X.; Liu, X.; Hu, J.; Zhang, P.; Xu, Z.; Wang, D. and Xu, W.*, Fabrication of Strong Tough Hydrogels Inspired by the Hydration-Flexibilization Process of Discinisca tenuis Shells. ACS Appl. Poly. Mater., 2024, 6 (19), 12311-12320. (Corresponding Author)
3. Zhu, Q.; Fu, M.; Qi, J.; Xu, Z.; Wang, Y.; Wang, Z.; Wang, D.; Liu, J.; Du, R.; Wei, X.; Wang, H.; Nie, J.; Hong, B. and Xu, W.*, Cisplatin resistance-related transcriptome and methylome integration identifies PCDHB4 as a novel prognostic biomarker in small cell lung cancer. iScience, 2024, 27(8): 110413. (Corresponding Author)
4. Wei, X.; Wang, D.; Liu, J.; Zhu, Q.; Xu, Z.; Niu, J. and Xu, W.*, Interpreting the Mechanism of Active Ingredients in Polygonati Rhizoma in Treating Depression by Combining Systemic Pharmacology and In Vitro Experiments. Nutrients, 2024, 16(8): 1167. (Corresponding Author)
5. Tang, H.; Wang, L.; Liu, S.; Wei, X.; Lv, M.; Zhong, F.; Liu, Y.; Liu, J.; Fu, B.; Zhu, Q.; Wang, D.; Liu, J.; Ruan, K.; Gao, J. and Xu, W.*, Inhibitors against Two PDZ Domains of MDA-9 Suppressed Migration of Breast Cancer Cells. Int. J. Mol. Sci., 2023, 24(4): 3431. (Corresponding Author)
6. Zheng, D.; Zhang, X.; Zhang, Y.; Fan, W.; Zhao, X.; Gan, T.; Lu, Y.; Li, P. and Xu, W.*, In situ construction of Fe3O4@PDA@Au multi hotspot SERS probe for trace detection of benzodiazepines in serum. Spectrochim. Acta Part A., 2023, 300: 122897. (Corresponding Author)
7. Lu, Y.; Liu, Q.; Fu, B.; Li, P. and Xu, W.*, Label-free MIP-SERS biosensor for sensitive detection of colorectal cancer biomarker. Talanta, 2023, 258: 124461. (Corresponding Author)
8. Yao, M.; Zhang, Q.; Wang, D.; Chen, R.; Yin, Y.; Xia, J.; Tang, H.; Xu, W.* andYu, S.*, M.;Lead-Free Halide CsAg2I3 with 1D Electronic Structure and High Stability for Ultraviolet Photodetector. Adv. Funct. Mater., 2022, 32(28): 2202894. (Corresponding Author)
9. Yao, M.; Tang, H.; Yin, Y.; Zhang, X.; Lu, Y.; Zhao, X.; Gan, T. and Xu, W.*,Tuning the surface enhanced Raman spectroscopy performance of Au core-Ag shell nanostructure for label-free highly sensitive detection of colorectal cancer Marker. J. Alloys Compd., 2022, 896: 163043. (Corresponding Author)
10. Zhang, H.; Fang, W.; Zhao, T.; Zhang, H.;Gao, L.; Li, J.; Wang, R. and Xu, W.*, Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ Cartilage Regeneration. Front. Bioeng. Biotech., 2022, 10. (Corresponding Author)
11. Zhang, X.; Luan, L.; Huang, Y.; Yao, M.; Li, P. and Xu, W.*, Mussel-inspired PDA-based MIP-SERS sensor for the detection of trace MG in environmental water. Analyst, 2022, 147(24): 5701-9. (Corresponding Author)
12. Li, M.; Li, J.; Zhang, X.; Yao, M.; Li, P. and Xu, W.*, Simultaneous detection of tumor-related mRNA and miRNA in cancer cells with magnetic SERS nanotags. Talanta, 2021, 232, 122432. (Corresponding Author)
13. Wang, Q.; Wang, J.; Li, M.; Ge, Z.; Zhang, X.; Luan, L.; Li, P. and Xu, W.*, Size-dependent surface enhanced Raman scattering activity of plasmonic AuNS@AgNCs for rapid and sensitive detection of Butyl benzyl phthalate. Spectrochim. Acta Part A., 2021, 248, 119131. (Corresponding Author)
14. Yao, M.-M.; Wang, L.; Yao, J.-S.; Wang, K.-H.; Chen, C.; Zhu, B.-S.; Yang, J.-N.; Wang, J.-J.; Xu, W.*; Zhang, Q.*; Yao, H.-B.*, Improving Lead-Free Double Perovskite Cs2NaBiCl6 Nanocrystal Optical Properties via Ion Doping. Adv. Opt. Mater., 2020, 8 (8), 1901919. (Corresponding Author)
15. Li, J.; Hu, X.; Zhou, Y.; Zhang, L.; Ge, Z.; Wang, X. and Xu, W.*, β-Cyclodextrin-Stabilized Au Nanoparticles for the Detection of Butyl Benzyl Phthalate. ACS Appl. Nano Mater., 2019, 2 (5), 2743-2751. (Corresponding Author)
16. Hu, X.; Wang, X.; Ge, Z.; Zhang, L.; Zhou, Y.; Li, J.; Bu, L.; Wu, H.; Li, P. and Xu, W.*, Bimetallic plasmonic Au@Ag nanocuboids for rapid and sensitive detection of phthalate plasticizers with label-free surface-enhanced Raman spectroscopy. Analyst, 2019, 144 (12), 3861-3869. (Corresponding Author)
17. Zhao, Z.-b.; Ji, K.; Shen, X.-y.; Zhang, W.-w.; Wang, R.; Xu, W.*; Wei, W., Di(2-ethylhexyl) phthalate promotes hepatic fibrosis by regulation of oxidative stress and inflammation responses in rats. Environ. Toxicol. Phar., 2019, 68, 109-119. (Corresponding Author)
18. Zhou, Y.; Li, J.; Zhang, L.; Ge, Z.; Wang, X.; Hu, X.; Xu, T.; Li, P. and Xu, W.*, HS-β-cyclodextrin-functionalized Ag@Fe3O4@Ag nanoparticles as a surface-enhanced Raman spectroscopy substrate for the sensitive detection of butyl benzyl phthalate. Anal. Bioanal. Chem., 2019, 411 (22), 5691-5701. (Corresponding Author)
Contact Information
E-mail: xwp5606@163.com
Phone: 0551-62283106
Expert Introduction: [USTC Expert Introduction](https://www.ustc.edu.cn/)
Weiping Xu | Publons: [Weiping Xu Profile](https://publons.com/researcher/Weiping_Xu)