Main Research Interests and Directions
1. Transcriptional regulation and cell fate determination
2. Development and in vitro generation of human germ cells
3. Establishment of stem cell disease models
- Earned a PhD in Computational and Systems Biology from the joint program of the National University of Singapore and MIT in 2011.
- Conducted postdoctoral research at Stanford University School of Medicine from 2011 to 2014.
- Worked as a research scientist at Montana State University from 2014 to 2019.
- Joined the School of Life Sciences and Medicine at the University of Science and Technology of China in December 2019.
- Recently published research as first author/corresponding author in journals such as Nature Cell Biology, Nature Communications, and Cell Reports.
Representative Papers
1) Fang F (#) (*), Angulo B, Xia N, Sukhwani M, Wang Z, Carey CC, Mazurie A, Cui J, Wilkinson R, Wiedenheft B, Surani AM, Orwig KE, Reijo Pera RA. A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells. Nature Cell Biology 20，655-665 (2018).
2) Fang F(#) (*), Xia N(#), Angulo B, Carey J, Durruthy-Durruthy J, Sebastiano V, Bennett T, Reijo Pera RA. A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells in conjunction with master transcription factors. Nature Communications 9, 4384 (2018).
3) Xia N(#) (*), Fang F(#) , Zhang P(#) , Cui J, Tep-Cullison C, Hamerley T, Lee HJ, Palmer T, Bothner B, Lee HJ, Reijo Pera RA. A Knock-In Reporter allows purification and characterization of mDA neurons from heterogeneous populations. Cell Reports. 18(10):2533-2546 (2017).
4) Xia N(#) (*), Zhang, P(#) , Fang, F(#) , Wang Z, Rothstein M, Augulo B, Chiang R, Taylor J, Reijo Pera RA. Transcriptional comparison of human induced and primary midbrain dopaminergic neurons. Scientific Reports. 6, 20270 (2016).
5) Fang F(#) (*), Xu Y(#), Chen X, Ng HH(*), Matsudaira, P. Coactivators p300/CBP regulate self-renewal in embryonic stem cells by mediating long-range chromatin structure. Stem Cells.32(7):1805-16 (2014).
Publication Links:
NCBI:https://www.ncbi.nlm.nih.gov/sites/myncbi/1-AJPnsHwlK/bibliography/49662821/public/?sort=date&direction=ascending
Google Scholar: https://scholar.google.com/citations?user=XIiTV58AAAAJ&hl=en
Recruitment
1. The lab is recruiting postdoctoral fellows and specially appointed associate researchers with backgrounds in cell biology, molecular biology, or bioinformatics.
2. Students interested in pursuing a PhD or internship in stem cell biology, reproductive biology, and developmental biology are welcome.
3. Hiring one research assistant with a master's degree or higher to manage basic lab operations and assist research team members.
Contact Information
E-mail: ffang24@ustc.edu.cn