Graduated from the Department of Biological Sciences at Nanjing University in 2005; obtained a PhD from the National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China (USTC) in 2011. From 2011 to 2013, conducted postdoctoral research at the Institute of Immunology, USTC. Between 2013 and 2019, served as an Associate Researcher/Associate Professor at USTC, and in 2019 became a Specially Appointed Professor at USTC. Focuses on reproductive immunology, pro. Binqing Fu has elucidated the immunoregulatory functions of decidual NK cells at the maternal-fetal interface in early pregnancy, revealing the important role of the decidua-specific CD49a+ NK cell subset in promoting embryo development, and developed a new technology for non-invasive immune endometrial monitoring system and inducing decidual-like NK cell transfer to treat embryo developmental disorders. She have been published in high-impact journals such as Nature Immunology, Immunity, Science Translational Medicine, and PNAS. She received the Young Scholar Award from the Chinese Society for Immunology in 2015; Selected for the National Science Fund for Excellent Young Scholars in 2019 and became a member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences. In 2020, she has been recognized as a New Star in the Teaching Arena of Anhui Province. As a project leader, she has received funding from several National Natural Science Foundation projects and participated in key national research programs and innovation groups.
Research Directions and Interests
1. The role and mechanisms of immune cells, especially NK cells, at the maternal-fetal interface during pregnancy;
2. Key mechanisms regulating the development and functional transformation of immune cells at the maternal-fetal interface;
3. The relationship between immune cells at the maternal-fetal interface and pregnancy-related diseases and offspring birth defects.
Simultaneously, we are committed to developing new clinical diagnostic and therapeutic methods targeting the endometrial microenvironment.
Recent Research Papers
- Wei H.*, Fu B*. Make killers sweeter: targeting metabolic checkpoints of NK cells. Nat Immunol (2020). [https://doi.org/10.1038/s41590-020-0738-x](https://doi.org/10.1038/s41590-020-0738-x)
- Binqing Fu, Xiaoling Xu, Haiming Wei. Why tocilizumab could be an effective treatment for severe COVID-19? Journal of Translational Medicine, (2020) Apr 14; 18(1):164.
- Zhou YG#, Fu BQ#, Zheng XH#, Wang DS, Zhao CC, Qi YJ, Sun R, Tian ZG, Xu XL, Wei HM: Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. National Science Review, 2020, nwaa041, [doi.org/10.1093/nsr/nwaa041](https://doi.org/10.1093/nsr/nwaa041)
- Yonggang Zhou, Binqing Fu*, Xiuxiu Xu, Jinghe Zhang, Xianhong Tong, Yanshi Wang, Zhongjun Dong, Xiaoren Zhang, Nan Shen, Yiwen Zhai, Xiangdong Kong, Rui Sun, Zhigang Tian*, Haiming Wei*: PBX1 Expression in Uterine Natural Killer Cells Drives Fetal Growth. Science Translational Medicine, 2020 Apr 1; 12(537):eaax1798.
- Fu B#, Wang D#, Shen X, Guo C, Liu Y, Ye Y, Sun R, Li J, Tian Z and Wei H (2020) Immunomodulation Induced During Interferon-α Therapy Impairs the Anti-HBV Immune Response Through CD24+CD38hi B Cells. Frontiers in Immunology 11:591269.
- Xiang Ni, Binqing Fu*, Jinghe Zhang, Rui Sun, Zhigang Tian*, Haiming Wei* Cytokine Based Generation of CD49a + Eomes -/+ Natural Killer Cell Subsets. Frontiers in Immunology 2018, 9: 2126
- Binqing Fu#, Yonggang Zhou#, Xiang Ni#, Xianhong Tong, Xiuxiu Xu, Zhongjun Dong, Rui Sun, Zhigang Tian*, Haiming Wei* Natural killer cells promote fetal development through the secretion of growth-promoting factors. Immunity 47, 1100–1113, 2017 (Cover Article, F1000 Recommended)
- Binqing Fu, Xianchang Li, Rui Sun, Xianhong Tong, Bin Ling, Zhigang Tian, and Haiming H Wei. Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. PNAS 110(3):231-240 (2013) (F1000 Recommended)
(Note: # denotes co-first authors; * denotes co-corresponding authors)
Contact Information
Address: Institute of Immunology, School of Life Sciences, University of Science and Technology of China, 443 Huangshan Road, Hefei
E-mail: fbq@ustc.edu.cn