Research Interests
Utilizing Bio-X interdisciplinary techniques such as chemical biology, immunology, and structural biology to study:
1. Tumor immunology of Natural Killer cell. We employ chemical biology methodologies to manipulate the tumor microenvironment, elucidating novel mechanisms by which NK cells can overcome this hostile milieu. Additionally, we identify potential targets and develop innovative therapeutics to enhance the immunotherapeutic efficacy of NK cells.
2. Natural Killer cell synthetic immunology. By integrating interdisciplinary techniques encompassing chemistry, biology, and allied fields, we develop innovative NK cells with precise tumor-targeting capability for clinical immunotherapy.
- Dual-appointed as a young outstanding talent at the School of Life Sciences and Medicine, University of Science and Technology of China, and the First Affiliated Hospital (Hepatobiliary and Pancreatic Surgery).
- Principal Investigator at the Molecular Medicine Division of the National Key Laboratory for Microscale, and the CAS Key Laboratory of Innate Immunity and Chronic Disease.
- Established an interdisciplinary research lab in immunology/chemical biology in 2020.
- Published as corresponding author in journals such as EMBO Reports and J. Am. Chem. Soc., and as first/co-first author in Nature, PNAS, Cell Chem Biol, eLife.
- Lead projects funded by the National Natural Science Foundation of China in 2020 and 2023.
- Leading the 2023-2026 Global Selection Project (Innovative Drugs) at the Hefei Comprehensive National Science Center Health Institute.
Education and Work Experience
- Graduated from the School of Life Sciences, University of Science and Technology of China in 2009.
- Earned a PhD from the Li Ka Shing Faculty of Medicine, University of Hong Kong in 2014, awarded the Hong Kong SAR Young Scientist Award.
- Joint PhD training at Cornell University, Department of Chemistry and Chemical Biology, in the lab of HHMI Investigator Professor Hening Lin.
- From 2014, served as Postdoctoral Fellow, Research Assistant Professor, and Senior Assistant Researcher at the Li Ka Shing Faculty of Medicine, University of Hong Kong.
- From 2019, Independent PI at the Precision Medicine Institute, First Affiliated Hospital of Sun Yat-sen University.
- From 2020, Distinguished Researcher at the School of Life Sciences and Medicine, University of Science and Technology of China.
Publications
1. Jing Jin#,* Lin Bai#, Dongyao Wang#, Wei Ding, Zhuoxian Cao, Peidong Yan, Yunjia Li, Lulu Xi, Yuxin Wang, Xiaohu Zheng, Haiming Wei, Chen Ding*, Yi Wang*. SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth. EMBO Reports, 2023.
2. Yunjia Li, Jing Jin, Yi Wang*. SIRT6 Widely Regulates Aging, Immunity, and Cancer. Front. Oncol., 06 April 2022.
3. Jing Jin, Bin He, Xiaoyu Zhang, Hening Lin*, Yi Wang*. SIRT2 reverses 4-oxononanoyl lysine modification on histones. J. Am. Chem. Soc., 2016, 138 (38), pp 12304–12307.
4. Yi Wang#, Jing Jin#, Matthew Wai Heng Chung#, Ling Feng, Hongyan Sun, Quan Hao. Identificationof the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation. Proc Natl Acad Sci U S A. 2018, Feb 20. pii: 201717664.
5. Yi Wang, Yi Man Eva Fung, Weizhe Zhang, Bin He, Matthew Wai Heng Chung, Jing Jin, Jing Hu, Hening Lin, Quan Hao. De-acylation Mechanism by SIRT2 Revealed in an Intermediate Structure. Cell Chemical Biology, 2017. 16; 24(3): 339-345.
6. Xiucong Bao#, Yi Wang#, Xin Li#, Xiao-Meng Li#, Zheng Liu, Tangpo Yang, Chi Fat Wong, Jiangwen Zhang, Quan Hao, Xiang David Li. Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach. eLife. 2014; 3: e02999.
7. Hong Jiang#, Saba Khan#, Yi Wang#, Guillaume Charron, Bin He, Carlos Sebastian, Jin tang Du, Ray Kim, Eva Ge, Raul Mostoslavsky, Howard C. Hang, Quan Hao & Hening Lin. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013, 496, (110–113).
8. He Huang, Di Zhang, Yi Wang, Mathew Perez-Neut, Zhen Han, Y. George Zheng, Quan Hao & Yingming Zhao. Lysine benzoylation is a histone mark regulated by SIRT2. Nature Communications, 2018, v. 9 n. 1, p. 3374
9. Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao, and Hening Lin. SIRT7 is an RNA-activated protein lysine deacylase. ACS Chem. Biol. 2016, DOI: 10.1021/acschembio.6b00954.
10. Yusheng Xie, Jingyan Ge, Haipeng Lei, Bo Peng, Huatang Zhang, Danyang Wang, Sijun Pan, Ganchao Chen, Lanfang Chen, Yi Wang, Quan Hao, Shao Q. Yao, Hongyan Sun. Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases. J. Am. Chem. Soc., 2016, 138 (48), pp 15596–15604
11. Zhen Tong, Yi Wang, Xiaoyu Zhang, David D. Kim, Sushabhan Sadhukhan, Quan Hao, Hening Lin*. SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS Chem. Biol. 2016, 11, 742−747
12. Shrestha Ghosh, Baohua Liu, Yi Wang, Quan Hao, Zhongjun Zhou. Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair. Cell report. 2015, 1396–1406
13. Yi Wang, Yong-Xing He, Jiang Yu and Cong-Zhao Zhou*. Cloning, overproduction, purification, crystallization and preliminary X-ray diffraction analysis of yeast glutaredoxin Grx5. Acta Crystallographica Section F, 2009, ISSN 1744-3091
Contact Information
We invite dedicated undergraduate students interested in interdisciplinary research in immunology/chemical biology to pursue PhD positions in our laboratory. We also have ongoing recruitment for postdoctoral fellows and research assistants. If you are interested, please submit your CV (including personal information, educational background, work experience, publications, and other achievements) to: wy83@ustc.edu.cn; Phone: 0551-63603117.