Research Areas
Nanomedicine, Biomaterials, Biomedical Polymers, In Vivo Microscopy
PhD, Professor, PhD Supervisor at the Key Laboratory of Innate Immunity and Chronic Disease, Chinese Academy of Sciences.
Education
- Bachelor’s degree in Polymer Chemistry and Physics, University of Science and Technology of China (USTC), 2005
- PhD in Polymer Chemistry and Physics, USTC, 2010
Postdoctoral Research
- Washington University in St. Louis, Department of Biomedical Engineering, 2010, under Prof. Younan Xia
- Georgia Institute of Technology, Department of Biomedical Engineering, 2011, under Prof. Younan Xia
- University of Chicago, James Franck Institute, 2012-2015, under Prof. Bozhi Tian
Professional Experience
- Professor, School of Life Sciences, USTC, September 2015-present
Research Contributions
- Focused on nanomaterials for cancer therapy and imagin
- Published over 70 research papers in journals such as Nat Mater, Nat Commun, PNAS, Nano Letters, ACS Nano
- Cited over 5000 times with an H-index of 39
Awards
- 2016: Young Scientist Award, China-Korea Biomaterials Association
- 2018: 45 under 45 Global Young Scientist Award in Nanobiotechnology
Funded Projects
1. Research on anti-tumor nanomedicine with hydrophilic shell of polyphosphate esters, National Natural Science Foundation of China General Project, 51773191, PI, 2018.1-2022.12
2. Nanomedicine research based on tumor microenvironment regulation, Key Program of Nanotechnology, 2017YFA0205600, Participant
3. Surface characteristics control of polymer nanomedicines and their intervention in cellular immune functions, National Natural Science Foundation of China Key Project, 51633008, Participant, 2017.1-2021.12
4. Controlled synthesis of polyphosphate ester macromolecular prodrugs initiated by drug molecules for cancer treatment, National Natural Science Foundation of China General Project, 51573176, PI, 2015.10-2019.10
Representative Papers (Last Five Years)
[1] S. Li, Q. Wang, Y. Shen, M. Hassan, J. Shen, W. Jiang, Y. Su, J. Chen, L. Bai, W. C. Zhou, Y. C. Wang. Pseudoneutrophil Cytokine Sponges Disrupt Myeloid Expansion and Tumor Trafficking to Improve Cancer Immunotherapy. Nano Letters, 2019, in press.
[2] Y.Ma,#Y. Zhang,#;X. Li,#Y. Zhao, M. Li, W. Jiang, X. Tang, J. Dou, L. Lu, F. Wang, Y. C. Wang. Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy. ACS Nano, 2019, 13, 11967-11980.
[3] Y. Ma,# Y. Zhao,#N. K. Bejjanki,# X. Tang, W. Jiang, J. Dou, M. I. Khan, Q. Wang, J. Xia, H. Liu, Y. You, G. Zhang, Y. C. Wang, J. Wang.Nanoclustered Cascaded Enzymes for Targeted Tumor Starvation and Deoxygenation-Activated Chemotherapy without Systemic Toxicity. ACS Nano, 2019, 13, 8890-8902.
[4] P. Chen,#Y. Ma,# Z. Zheng,#C. Wu, Y. C. Wang, G. L. Liang, Facile Syntheses of Conjugated Polymers for Photothermal Tumour Therapy. Nature Communications, 2019, 10:1192.
[5] Y. Zhang,#Y. Zhao,#J. Shen,# X. Sun, Y. Liu, L. Hang, H. Liu, Y. C. Wang, J. Wang &Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy. Nano Letters, 2019, 19, 2774-2783.
[6] W.Jiang,#;Z. Zhang,# Q. Wang,# J. Dou, Y. Zhao, Y. Ma, H. Liu, H. X. Xu, Y. C. Wang. Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets.Nano Letters, 2019, 19, 4060-4067.
[7] Y. Liu,# N. K. Bejjanki,# W. Jiang, Y. Zhao, L. Wang, X. Sun, X. Tang, H. Liu, Y. C. Wang. Controlled Syntheses of Well-Defined Poly(thionophosphoester)s that Undergo Peroxide-Triggered Degradation. Macromolecules, 2019, 52, 4306-4316.
[8] H. Wang, Y. Hou, Y. Hu, J. Dou, Y. Shen, Y. C. Wang, H. Lu. Enzyme-Activatable Interferon-Poly(α-amino acid) Conjugates for Tumor Microenvironment Potentiation. Biomacromolecules,2019, 20, 3000-3008.
[9] L Yang, X Chen, L Wang, Z Hu, N Xin, M Hippler, W Zhu, Y Hu, J Li, Y. C. Wang, L Zhang, D Wu, J Chu. Targeted Single-Cell Therapeutics with Magnetic Tubular Micromotor by One-Step Exposure of Structured Femtosecond Optical Vortices. Advanced Functional Materials, 2019, in press.
[10]W. Huang, X. Zhang, B. Chen, H. Miao, C. O. Trindle, Y. C. Wang, Y. Luo, G. Zhang. Boosting the Triplet Activity of Heavy-Atom-Free Difluoroboron Dibenzoylmethane viasp3 Oxygen-Bridged Electron Donors. Chemical Communications, 2019, 55, 67-70
[11]Huang, T. Wu, H. Shi, Y. Wu, H. Yang, K. Zhong, Y. C. Wang, Y. Liu. Modular Design of Nanobody-Drug Conjugates for Targeted-Delivery of Platinum Anticancer Drug with MRI Contrast Agent. Chemical Communications, 2019, 55, 5175-5178.
[12] B.Chen, X. Zhang, Y. C. Wang, H. Miao, G. Zhang. Aggregation-Induced Emission with Long-Lived Room-Temperature Phosphorescence from Methylene-Linked Organic Donor-Acceptor Structures, Chemistry-An Asian Journal, 2019, 14, 751-754.
Contact Information
Email: yucaiwang@ustc.edu.cn