Personal Profile
PhD, Joint Special Research Fellow. Recipient of the Outstanding Doctoral Dissertation Award from the Chinese Academy of Sciences, reserve candidate for Academic and Technical Leaders of Anhui Province, and recipient of the First Prize of Science and Technology Award of Anhui Province (2/4). Dr. Chen received the PhD in Biochemistry and Molecular Biology from the University of Science and Technology of China (USTC). He focuses on the functions and functional mechanisms of non-coding RNA in major diseases such as cancer and cardiovascular diseases. He previously served as a postdoctoral researcher and associate research fellow at the School of Basic Medicine, USTC. Since April 2023, he has been jointly appointed by the School of Life Sciences and Medicine at USTC and the Cardiovascular Research Institute of the First Affiliated Hospital of USTC. During this period, he has received and presided over projects funded by the National Natural Science Foundation, Anhui Provincial Natural Science Foundation, Anhui Provincial Universities Outstanding Youth Research Program, National Postdoctoral Science Foundation, USTC Youth Innovation Fund, and participated in the National Key R&D Programs by the Ministry of Science and Technology of China. His major research findings were published in journals such as Nature Communications, PNAS, Trends in Biochemical Sciences, Oncogene, Genome Research, Cancer Letters. He was awarded the Outstanding Publication Research Award by the School of Life Sciences, USTC. He is currently a member of the Standing Committee of the Cardiovascular Branch of the Anhui Society of Pathophysiology, and a member of the Familial and Hereditary Tumors Branch of the Anhui Anti-Cancer Association.
Main Research Interests
1. Functions and functional mechanisms of non-coding RNAs (such as circular RNAs and long noncoding RNAs) in cancers and cardiovascular diseases.
2. Molecular mechanisms of noncoding RNAs in regulating tumor metastasis and drug resistance, drug screening.
3. Noncoding RNAs and external stress response regulation.
4. Circular RNA biogenesis, nuclear export regulation, and the physiopathological relevance.
Representative Publications (First/Corresponding Author)
(1) Yinchun Zhong#, Yan Yang#, Xiaolin Wang, Bingbing Ren, Xueren Wang*, Ge Shan*, Liang Chen*, Systematic identification and characterization of Exon-intron circRNAs, Genome Research, 2024, 34(3):376-393.
(2) Hanyuan Liu, Sisi Deng, Xuelin Yao, Yi Liu, Lili Qian, Yingying Wang, Tianjiao Zhang, Ge Shan*, Liang Chen*, Ying Zhou*, Ascites exosomal lncRNA PLADE enhances platinum sensitivity by inducing R-loops in ovarian cancer, Oncogene, 2024, 43(10):714-728.
(3) Gui-Bin Gao#, Liang Chen#, Jia-Feng Pan, Tao Lei, Xin Cai, Zhexue Hao, Qi Wang, Ge Shan, Jin Li*, LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer, Cancer Letters, 2024, 216826.
(4) Shuhui Chang#, Yucong Wang#, Xiaolin Wang, Hanyuan Liu, Tao Zhang, Yangge Zheng, Xueren Wang, Ge Shan*, Liang Chen*, HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes, RNA Biology, 2024, 21(1):1-15.
(5) Xu Liu#, Xuelin Yao#, Liang Chen*, Expanding roles of circRNAs in cardiovascular disease, Non-coding RNA Research, 2024, 9(2):429-436
(6) Xuelin Yao#, Hanyuan Liu#, Zhen Wang, Fangting Lu, Wenying Chen, Qing Feng, Yahu Miao, Jie Zhang, Yanlei Wang, Ye Chen, Liping Xue, Yehai Liu, Liang Chen*, Qiu Zhang*, Circular RNA EIF3I promotes papillary thyroid cancer progression by interacting with AUF1 to increase Cyclin D1 production, Oncogene, 2023, 42(43):3206-3218.
(7) Sisi Deng; Lili Qian; Luwen Liu; Hanyuan Liu; Zhihao Xu; Yujie Liu; Yingying Wang; Liang Chen*; Ying Zhou*; Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1, Cancer Science, 2023, 114(4):1582-1595
(8) Liang Chen#; Yucong Wang#; Jiamei Lin; Zhenxing Song; Qinwei Wang; Wenfang Zhao; Yan Wang; Xiaoyu Xiu; Yuqi Deng; Xiuzhi Li; Qiqi Li; Xiaolin Wang; Jingxin Li; Xu Liu; Kunpeng Liu; Jincong Zhou; Kuan Li; Yuchan Liu; Shanhui Liao; Qin Deng; Chao Xu; Qianwen Sun; Shengzhou Wu; Kaiming Zhang; Min-Xin Guan; Tianhua Zhou; Fei Sun; Xiujun Cai; Chuan Huang*; Ge Shan*; Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs, Nature Communications, 2022, 13(1): 5769
(9) Liang Chen, Chuan Huang*, Ge Shan*; Circular RNAs in physiology and non-immunological diseases, Trends in Biochemical Sciences, 2022, 47(3): 250-264
(10) Pengcheng Liu#; Yucong Wang#; Ningning Zhang; Xiaomin Zhao; Renming Li; Yu Wang; Chen Chen; Dandan Wang; Xiaoming Zhang; Liang Chen*; Dahai Zhao*; Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease., Respiratory Research, 2022, 23(1): 154-154
(11) Liang Chen*, Ge Shan*, CircRNA in cancer: Fundamental mechanism and clinical potential, Cancer Letters, 2021,18;505:49-57.
(12) Hanyuan Liu, Chenchen Zhu, Zhihao Xu, Juan Wang, Lili Qian, Qingqing Zhou, Zhen Shen, Weidong Zhao, Weihua Xiao, Liang Chen*, Ying Zhou*; lncRNA PART1 and MIR17HG as δNp63 alpha direct targets regulate tumor progression of cervical squamous cell carcinoma, Cancer Science, 2020, 111(11): 4129-4141
(13) Ying Zhou#; Hanyuan Liu#; Juan Wang; Xiaolin Wang; Lili Qian; Fei Xu; Weiguo Song; Dabao Wu; Zhen Shen; Dingqing Feng; Bin Ling; Weihua Xiao; Ge Shan*; Liang Chen*; ΔNp63α exerts antitumor functions in cervical squamous cell carcinoma, Oncogene, 2019, 39: 905-921
(14) Zhiyong Sheng, Xiaolin Wang, Geliang Xu*, Ge Shan*, Liang Chen*, Analyses of a panel of transcripts identified from a small sample size and construction of RNA networks in hepatocellular carcinoma, Frontiers in Genetics, 2019, 10:431.
(15) Liang Chen*, Emmanuel Enoch Dzakah, Ge Shan*, Targetable long non-coding RNAs in cancer treatments, Cancer Letters, 2018, 418, 119–124.
(16) Hassaan M Awan#, Abdullah Shah#, Farooq Rashid#, Shuai Wei, Liang Chen*, Ge Shan*, Comparing two approaches of miR-34a target identification, biotinylated-miRNA pulldown vs miRNA overexpression. RNA Biology, 2018(15): 55-61.
(17) Abdullah Shah#, Farooq Rashid#, Hassaan M Awan#, Shanshan Hu, Xiaolin Wang, Liang Chen*, Ge Shan*, The DEAD-Box RNA Helicase DDX3 Interacts with m(6)A RNA Demethylase ALKBH5. Stem Cells International, 2017, 10.1155/ 2017/ 8596135.
(18) Liang Chen, Farooq Rashid, Abdullah Shah, Hassaan M Awan, Mingming Wu, An Liu, Jun Wang, Tao Zhu, Zhaofeng Luo, Ge Shan*, The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation, Proceedings of National Academy of Sciences U S A (PNAS), 2015, 112(32):10002-10007.
(19) Liang Chen, Ge Shan*, Circular RNAs remain peculiarly unclear in biogenesis and function, Science China Life Sciences, 2015, 58(6):616-618.
(20) Liang Chen, Chuan Huang, Xiaolin Wang, Ge Shan*, Circular RNAs in Eukaryotic Cells, Current Genomics, 2015, 16(5) :312-318.
Contact Information
Office: 0551-63601356
Email: anqingcl@ustc.edu.cn