Researcher and PhD Supervisor. Received a PhD in Cell Biology from the University of Science and Technology of China in 2006. Conducted postdoctoral research at the University of Chicago and St. Jude Children's Research Hospital in the USA. Joined the School of Life Sciences and Medicine at USTC in December 2018, focusing on fundamental research in autoimmune diseases and tumor immunology. Published over 20 SCI papers in journals such as STTT, Hepatology, and Nature Communications. Research achievements were selected as one of the Major Scientific Advances in China 2006 by Science and Technology Review (30 total, 7 in life sciences), and received the CAS President's Award for Excellence. Awarded the Anhui Provincial Outstanding Youth Fund in 2022.
Main Research Areas
Specific regulatory roles of cytokines in autoimmune diseases
Tumor immunotherapy and discovery of new targets
Detection and functional validation of important immune-related proteins and their antibodies
Publications
Cong M, Yang Y, Tong H, Shimu AS, Wang B, Li Q, Li F, Yang Y, Jin T*, Li B*. 3-dose of RBD vaccine is sufficient to elicit a long-lasting memory response against SARS-CoV-2 infection. Signal Transduct Target Ther. 2022;7(1):84.
Gong F, Wei HX, Qi J, Ma H, Liu L, Weng J, Zheng X, Li Q, Zhao D, Fang H, Liu L, He H, Ma C, Han J, Sun A, Wang B, Jin T*, Li B*. “Pulling-Force Spinning Top for Serum Separation Combined with Paper-Based Microfluidic Devices in COVID-19 ELISA Diagnosis.“ ACS Sensors. 2021, 6:2709-2719.
Wei HX, Wang B, Li B*. “IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology. Front Immunol. 2020 ;11:1315.
Koelink PJ , Bloemendaal FM, Li B, Westera L, Vogels EM, van RM, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR. “Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signaling.”Gut. 2020 69:1053-1063.
Li B Jones LL, Geiger TL. “IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORgammat Expression.”Journal of Immunology. 2018. 201:2934-2946.
Li B Gurung P, Malireddi RK, Vogel P, Kanneganti TD, Geiger TL.“IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.”Nature Communications. 2015. 6:6131.
Li B, Alli R, Vogel P, Geiger TL.“IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis.”Mucosal Immunology. 2014. 7:869-878.
Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A.“The transcription factor PLZF directs the effector program of the NKT cell lineage.”Immunity. 2008. 29:391-403.
Li B, Sun R, Wei H, Gao B, Tian Z.“Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism.” Hepatology. 2006. 43:1211-1219
Recruitment
The lab is hiring postdocs with backgrounds in immunology, molecular biology, or genetics. Students interested in immunology are welcome to pursue doctoral studies or internships.
Contact
Email: libf@ustc.edu.cn