Studied at the University of Science and Technology of China from 1997 to 2007, earning a PhD in Cell Biology. Continued postdoctoral research at the University of Pennsylvania, USA. Focused on the regulatory mechanisms of mitotic kinases during studies and research. Published numerous papers in prestigious journals such as *Science*, *Journal of Cell Biology*, and *Molecular Cell*. His work has been widely recognized by peers. Notably, his 2009 research published in *Science* was included in the 7th edition of the classic textbook *Molecular Cell Biology* in 2012.
Returned to China in 2013 to join the University of Science and Technology of China as a Professor and PhD Supervisor.
Main Research Interests:
1. Study of the regulatory network of mitotic kinase phosphatases.
2. Development of anti-cancer drugs based on the action network of mitotic kinase phosphatases and related substrates.
Published Articles:
Research Papers:
Liu D., Davydenko O., Lampson M.A. "Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing." *J Cell Biol.* 2012 Aug; 198:491-499.
Welburn J.P., Vleugel M., Liu D., Yates III J.R., Lampson M.A., Fukagawa T., Cheeseman I.M. "Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface." *Mol. Cell.* 2010 May; 38:383-392.
Liu D., Vleugel M., Backer C.B., Hori T., Fukagawa T., Cheeseman I.M., Lampson M.A. "Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase." *J Cell Biol.* 2010 March; 188:809-820.
Liu D., Vader G., Vromans M.J., Lampson M.A., Lens S.M. "Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates." *Science.* 2009 Mar; 323:1350-1353.
Liu D., Ding X., Du J., Cai X., Huang Y., Ward T., Shaw A., Yang Y., Hu R., Jin C., Yao X. "Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment." *J Biol Chem.* 2007 July; 282:21415-21424.
Liu D.†, Ge L.†, Wang F., Takahashi H., Wang D., Guo Z., Yoshimura S.H., Ward T., Ding X., Takeyasu K., Yao X. "Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation." *FEBS Lett.* 2007 Jul; 581:3563-3571. († equal contribution)
Liu D., Zhang N., Du J., Cai X., Zhu M., Jin C., Dou Z., Feng C., Yang Y., Liu L., Takeyasu K., Xie W., Yao X. 2006. "Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis." *Biochem Biophys Res Commun.* 2006 Apr; 345:394-402.
Xue Y.†, Liu D.†, Fu C., Dou Z., Zhou Q., Yao X. "A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins." *Chinese Science Bulletin.* 2006 Aug; 51:1836-1847. († equal contribution)
Reviews:
Liu D., Lampson M.A. "Regulation of kinetochore-microtubule attachments by Aurora B kinase." *Biochem Soc Trans.* 2009 Oct; 37(5):976-980.
Liu D., Jin C., Yao X. "Progress and perspective of the kinetochore-associated motor proteins." *Chinese Science Bulletin.* 2003 Jan; 48(2):111-117.
Contact Information:
Phone: 0551-63601619
Email: dliu919@ustc.edu.cn