Main Research Interests:
1. Structure and Function of Non-coding RNA: Utilize solution NMR (nuclear magnetic resonance) to study the structure of important non-coding RNAs and understand their structure-function relationships. During large-scale in vitro RNA transcription, employ different labeling strategies (^15N, ^13C, ^2H) for stable isotope labeling of target RNAs, and use multidimensional NMR experiments to obtain sequence and distance information for structural construction.
2. Protein-Protein and Protein-Nucleic Acid Interactions: Use X-ray crystallography to characterize key protein-protein and protein-nucleic acid interactions in gene expression regulation. For biomolecular complexes that are difficult to crystallize, employ X-ray small-angle scattering combined with molecular dynamics simulations to obtain structural information. Current research systems include: E. coli RNA chaperone Hfq and its interaction with RNA, and the recognition mechanism between tRNA methyltransferase Trm10 and tRNA.
Study Experience:
Bachelor's degree in Material Science and Engineering from the University of Science and Technology of China (1994)
Master's degree in Molecular Biology from the University of Science and Technology of China (1997)
PhD in Biochemistry from Hong Kong University of Science and Technology (2002)
Work Experience:
Postdoctoral research at Carnegie Mellon University (2003-2006) and the University of Pittsburgh (2006-2008)
NMR Applications Engineer at Bruker Biospin, Mid-Atlantic USA (2008-2009)
Joined the School of Life Sciences, University of Science and Technology of China, as an Associate Professor in September 2009 through the "Overseas Talent Introduction" program
Supported by the CAS "Introduction of Outstanding Technical Talent" in 2010
Current Projects:
National Natural Science Foundation of China General Program
Major Research Plan on RNA Cultivation Project
Representative Papers:
1. An, Liwei, Jiang, Yiyang, Ng, Howin H. W, Man, Ellen P. S., Chen, Jie, Khoo, Ui-Soon(*),Gong, Qingguo(*) & Huen, Michael S. Y.(*). Dual-utility NLS drives RNF169-dependent DNA damage responses.Proceedings of the National Academy of Sciences, 2017, 201616602.
2. Wang Lijun, Wang Weiwei, Li Fudong, Zhang Jihai, Wu Jihui,Gong Qingguo(*)，Shi Yunyu(*), Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq,Nucleic Acids Research, 2015, 43(4):2400-11
3. Zhao, Debiao, Wang, Xuejuan，Peng, Junhui, Wang, Chongyuan, Li, Fudong, Sun, Qianqian, Zhang, Yibo, Zhang, Jiahai, Cai, Gang, Zuo, Xiaobing, Wu, Jihui, Shi, Yunyu, Zhang, Zhiyong(*),Gong, Qingguo(*), Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin,Journal of Structural Biology, 2014, 187(2): 194-205
4. Zou, Yang, Shao, Zhenhua, Peng, Junhui, Li, Fudong, Gong, Deshun, Wang, Chongyuan, Zuo, Xiaobing, Zhang, Zhiyong, Wu, Jihui, Shi, Yunyu,Gong, Qingguo(*), Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4,FEBS Letters, 2014, 588(17): 2911-2920
5. Shao, Zhenhua, Yan, Wei, Peng, Junhui, Zuo, Xiaobing, Zou, Yang, Li, Fudong, Gong, Deshun, Ma, Rongsheng, Wu, Jihui, Shi, Yunyu, Zhang, Zhiyong, Teng, Maikun, Li, Xu(*),Gong, Qingguo(*), Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate,Nucleic Acids Research, 2014, 42(1): 509-525
6. Wang, Weiwei, Wang, Lijun, Wu, Jihui,Gong, Qingguo(*), Shi, Yunyu(*), Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA,Nucleic Acids Research, 2013, 41(11): 5938-5948
Contact Information:
Tel: +86-551-63607644
Email: qgg@ustc.edu.cn