Graduated from the University of Science and Technology of China (USTC) in 2010, and received a Ph.D. from USTC in 2017. In the same year, joined St. Jude Children's Research Hospital in the USA for postdoctoral research under the guidance of National Academy of Sciences member, Dr. Douglas R. Green. Joined the School of Life Sciences and Medicine at USTC in July 2023. His primary research focuses on the impact of early events like asymmetric division after T cell activation on subsequent T cell fate and function. He has achieved a series of academic accomplishments, publishing multiple articles as the first author in renowned international journals such as Nature, Stem Cell Reports, and FASEB J, and has applied for two US patents related to CAR-T therapy.
Research Interests and Directions:
- Asymmetric division of CD8 T cells and the formation of memory T cells.
- Epigenetic and molecular mechanisms determining T cell fate, such as aging and exhaustion.
- Interactions between T cells and other cells in tumor and infection environments, and their impact on T cell fate.
- Differentiation of stem cells into T cells in vitro and optimization of related CAR-T immunotherapies.
Recruitment:
The lab is actively recruiting postdoctoral researchers with backgrounds in immunology, molecular and cellular biology, and epigenetics.
Students interested in pursuing a master's or doctoral degree in these research areas are warmly welcome.
Contact Information：
guoao@ustc.edu.cn
Published Articles:
Guo A, Huang H, Zhu Z, Chen M, Shi H, Sharma P, Liedmann S, Haydar D, Yang M, Beere H, Krenciute G, Roberts C.W.M, Chi H, and Green D.R. cBAF complex components and MYC cooperate early in CD8+ T cell fate. Nature 2022 https://doi.org/10.1038/s41586-022-04849-0
Zhu Z, Chen X, Guo A, Manzano T, Walsh P, Wills K, Halliburton R, Radko-Juettner S, Carter R, Partridge J, Green D.R., Zhang J, Roberts C.W.M. Mitotic bookmarking by SWI/SNF subunits. Nature 2023 https://doi.org/10.1038/s41586-023-06085-6
Liedmann S, Liu X, Guy C, Crawford JC, Rodrigues D.A., Kuzuoglu-Ozturk D, Guo A, Verbist K.C., Temirov J, Chen M.J., Ruggero D, Zhang H, Thomas P.G., Green D.R. Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate. Molecular Cell. 2022 https://doi.org/10.1016/j.molcel.2022.04.016
Li J*, Guo A*, Wang Q, Li Y, Zhao J, Lu J, Pei G. NF-κB directly regulates β-arrestin-1 expression and forms a negative feedback circuit in TNF-α-induced cell death. FASEB J. 2018 Aug;32(8):4096-4106.
Guo A, Huang S, Yu J, Wang H, Li H, Pei G, Shen L. Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization. Stem Cell Reports. 2017 May; 8(5):1124-1134.
Li H*, Guo A*, Xie Z, Tu W, Yu J, Wang H, Zhao J, Zhong C, Kang J, Li J, Huang S, Shen L. Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation. Scientific Reports. 2017 October 16; 7(1)
Xu H, Yue C, Zhang T, Li Y, Guo A, Liao J, Pei G, Li J, Jing N. Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells. Neuroscience Bulletin. 2017; 33(3):361-364.
Guo A, He D, Xu H, Geng C, Zhao J. Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents. Scientific Reports. 2015; 5(1).
Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G. Deficiency of -arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation. Proceedings of the National Academy of Sciences. 2013 April 15; 110(18):7395-7400.
Chen T, Shen L, Yu J, Wan H,Guo A, Chen J, Long Y, Zhao J, Pei G. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell. 2011 October; 10(5):908-911.