Main Research Interests:
Immune properties and functional regulation of human liver NK cells
Spatiotemporal heterogeneity of the liver through bioinformatics analysis
Discovery and validation of immunotherapy targets for human NK cells
Position:
Ph.D. in Life Sciences from USTC, 2012
Recipient of the Chinese Academy of Sciences President's Award
Awarded the Young Scholar Award by the Chinese Society of Immunology in 2014
Received the International Young Scholar Award from the Society for Immunotherapy of Cancer, USA, in 2015
Supported by the Anhui Provincial Outstanding Youth Fund in 2020
Supported by the National Science Foundation for Excellent Young Scholars
Professional Memberships and Publications:
Member of the Chinese Medical Association Organ Transplantation Branch
Editorial Board Member of the Chinese Journal of Immunology
Published 23 research papers as first or corresponding author in journals such as Hepatology, Nature Communications, Cancer Immunology Research, and Cancer Research
Recent Academic Papers:
Sun H(#), Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z(*), Sun C(*). Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2018 Nov 8. doi: 10.1002/hep.30347.
Sun C(#), Lan P(#), Han Q(#), Huang M, Zhang Z, Xu G, Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C, Tian Z(*). Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nature Communications. 2018 Mar 28;9(1):1241.
Sun H(#), Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C(*). Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma. Cancer Immunol Res. 2019 Sep;7(9):1535-1546.
Sun H(#), Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z(*), Sun C(*). Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC. Cancer Res. 2018 Sep 19.CAN-18-1049.
Sun C(#), Fu B, Gao Y, Liao X, Sun R, Tian Z(*), Wei H(*). TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathogens. 2012;8(3):e1002594.
Sun C(#)(*), Xu J, Huang Q, Huang M, Wen H, Zhang C, Wang J, Song J, Zheng M, Sun H, Wei H, Xiao W, Sun R, Tian Z(*). High NKG2A Expression Contributes to NK Cell Exhaustion and Predicts a Poor Prognosis of Patients with Liver Cancer. Oncoimmunology. Volume 6, 2017 6(1):e1264562.
Sun C(#), Sun H, Zhang C, Tian Z(*). NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma. Cell Mol Immunol. 2015 May;12(3):292-302.
Sun C(#), Sun HY, Xiao WH, Zhang C, Tian Z(*). Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy. Acta Pharmacol Sin. 2015 Oct;36(10):1191-9.
Wu T(#), Li F, Chen Y, Wei H, Tian Z, Sun C(*), Sun R(*). CD4+ T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model. Front Immunol. 2019 Apr 30;10:927.
Sun H(#)(*), Sun C(*). The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy. Front Immunol. 2019 Oct 17;10:2354.
Sun H(#), Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C(*). Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2017 May;32(5):1107-1114.
Sun H(#), Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C(*). CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma. Immunol Lett. 2016 Oct;178:105-13.
Yuwei Wu(#), Jinyu Wang(#), Xiaodong Zheng, Yongyan Chen, Mei Huang, Qiang Huang, Weihua Xiao, Haiming Wei, Zhigang Tian, Rui Sun(*)，Sun C(*) Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model. Immunol Lett. Volume 223, July 2020
Sun C(#), Xu J, Song J, Liu C, Wang J, Weng C, Sun H, Wei H, Xiao W, Sun R, Tian Z(*). The predictive value of centre tumour CD8⁺ T cells in patients with hepatocellular carcinoma: comparison with Immunoscore. Oncotarget. 2015 Nov 3;6(34):35602-15.
Sun H(#), Sun C, Tian Z, Xiao W. NK cells in immunotolerant organs. Cell Mol Immunol. 2013 May;10(3):202-12.
Sun H(#)(*), Sun C, Xiao W, Sun R. Tissue-resident lymphocytes: from adaptive to innate immunity. Cell Mol Immunol. 2019 Mar;16(3):205-215.
Lab Website: [http://sun.ustc.edu.cn](http://sun.ustc.edu.cn)
Recruitment:
The lab has a well-established technical system and comprehensive facilities. We are continuously recruiting postdoctoral researchers and special associate professors in biomedical or bioinformatics fields. Undergraduate students with these backgrounds are also welcome to pursue doctoral degrees in our lab.
Contact Information:
Phone: 0551-63600547
Email: charless@ustc.edu.cn