Professor
Contact Information
School of Life Sciences; University of Science & Technology of China
Tel: 86-551-63607977
Fax: 86-551 -63600832
E-mail: sunr@ustc.edu.cn

homepage:http://ioi.ustc.edu.cn
Personal Profile
03/1978-12/1982: Bachelor of Medicine, Shanxi Medical University, China
09/1997-06/2000: M.S., Immunology, Normal Bethune Med Univ, Changchun, China
10/1985-03/2001: Assistant/Associate/Full Professor, Shandong Acad Med Sci, China
09/1995-09/1996:Visiting Scientist, NCI, NIH, USA
03/2001-03/2002: Visiting Scientist, NCI, NIH, USA
04/2002-03/2006: Visiting Scientist, NIAAA, NIH, USA
06/2006-present: Professor, University of Science and Technology of China
Research Interests
1. Innate immune receptors of NK or NKT cells in liver diseases.
2. Innate immune receptors in tumor immunotherapy
3. Recognition mechanisms of innate immune receptors.
Selected Publications
1. Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jan 9. pii: S0168-8278(14)00956-8.
2. Wang W, Guo H, Geng J, Zheng X, Wei H, Sun R*, Tian Z*. Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack. J Biol Chem. 2014 Nov 28; 289 (48):33311-9.
3. Hou S, Ge K, Zheng X, Wei H, Sun R*, Tian Z*. CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain. J Biol Chem. 2014 Mar 7;289(10):6969-77.
4. Bi J, Zheng X, Chen Y, Wei H, Sun R*, Tian Z*. TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk. Hepatology. 2014 Oct; 60(4):1389-98.
5. Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R*, Tian Z*. T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis. Hepatology. 2014 May; 59(5):1715-25.
6. Hou S, Zheng X, Wei H, Tian Z, Sun R*. Recombinant soluble CD226 protein directly inhibits cancer cell proliferation in vitro. Int Immunopharmacol. 2014 Mar;19(1):119-26.
7. Geng J, Wang X, Wei H, Sun R*, Tian Z*. Efficient attenuation of NK cell-mediated liver injury through genetically manipulating multiple immunogenes by using a liver-directed vector. J Immunol. 2013 May 1;190(9):4821-9.
8. Li Y, Cao G, Zheng X, Wang J, Wei H, Tian Z, Sun R*. CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis. PLoS One. 2013 Sep 30;8(9):e76681.
9. Geng J, Wei H, Sun R*, Tian Z*.  Construction and application of a novel hepatocyte-directed vector to simultaneous knockdown and overexpression of multiple genes. Liver International. 2013, Aug;34(7):e246-56
10. Wang X, Qi Z, Wei H, Tian Z, Sun R*. Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice. Transpl Immunol. 2012 Mar;26(2-3):156-62.
11. Wang H, Zheng X, Wei H, Tian Z, Sun R*. Preparation and functional identification of a monoclonal antibody against the recombinant soluble human NKp30 receptor. Int Immunopharmacol. 2011 Nov;11(11):1732-9.
12.Wei H, Wei H, Wang H, Tian Z, Sun R*. Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via tumor necrosis factor-alpha-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 299(1):G275-82.