Professor and Ph.D. supervisor at School of Life Sciences, USTC
Tel:86-551-63602492
Fax:86-551-63600406
Homepage:
Personal Profile
Educational Background:
September 1980-July 1984, Bachelor's Degree, Department of Applied Physics, University of Science and Techlology of Harbin;
September 1987-May 1990, Master's Degree, Department of Applied Physics, University of Science and Technology of Harbin;
September 2000-September 2003, Doctor's Degree, University of Paris-Sud;
Main Work Experience:
July 1984-September 1987, Teaching Assistant at the Department of Applied Physics, University of Science and Technology of Harbin;
May 1990-August 1998, Lecturer at the Department of Applied Physics, University of Science and Technology of Harbin;
August 1998-March 1999, Associate Professor at the Department of Applied Physics, University of Science and Technology of Harbin;
March 1999-March 2000, Visiting Scholar at the Institute of Nuclear Physics of National Center for Scientific Research;
September 2003-April 2004, Postdoctoral Fellow at the Institute of Enzymology and Biochemistry of National Center for Scientific Research;
June 2004-April 2007, Professor and PhD. supervisor at the Institute for Protein Research, School of Life Sciences and Technology, Tongji University;
Since April 2007, Working in University of Science and Technology of China
Selected Pubications
1) The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. - Journal of Biological Chemistry - 2009 - 284(39)
2) Crystal Structure of the Yeast Cytoplasmic Thioredoxin Trx2 - Proteins: Structure, Function and Genetics. - 2007 -
3) Structural and kinetic analysis of Saccharomyces cerevisiae thioredoxin Trx1: implications for the catalytic mechanism of GSSG reduced by the thioredoxin system. - Biochim Biophys Acta - 2009 - 1794(8)
4) Expression, purification, crystallization and preliminary X-ray diffraction analysis of mitochondrial thioredoxin Trx3 from Saccharomyces cerevisiae - Acta Crystallographica Section F - 2006 -
5) Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues. - Biochim Biophys Acta - 2009 - 1794(4)
6) Adenosine Phosphonoacetic Acid is Slowly Metabolized by NDP Kinase. - Medicinal Chimistry - 2005 -
7) Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin - Biochim Biophys Acta - 2009 - 1794(1)
8) Development in structural genomics: protein purification and function interpretation - Current Genomics. - 2004 -
9) Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. - Journal Molecular Biology - 2003 -
10) Strcutural analysis of the activation of ribavirin analogues by NDP kinase: comparison with others ribavirin targets - Molecular Pharmacology - 2003 -
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